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Así concluyeron un grupo de investigadores que tomaron muestras de orina de pacientes con y sin fatiga crónica. El cortisol libre en orina resultó ser significativamente menor en los pacientes fatigados sin importar si había o no alguna otra enfermedad psiquiátrica previa.
Esos bajos niveles de cortisol libre tampoco se asociaron al empleo de medicación, a trastornos del sueño, u otros factores discapacitantes. En el estudio participaron 121 pacientes atendidos por el síndrome de fatiga crónica y 64 sujetos control, sin dicho síndrome.