Medical News
/ Published on September 30, 2001
Modelado farmacocinético
Mezcla de alfentanil y morfina para carga postoperatoria rápida con opioide: bases teóricas e investigación clínica inicial
Un protocolo de opioide intravenoso del dolor empleando mezcla de alfentanil-morfina en las proporciones 0.75:10 mg proveería un perfil de analgesia de inicio rápido, aún en desplazamiento lento.
Fuente: Anaesthesia 2001; 56: 739-744
Los investigadores evaluaron el régimen en 58 pacientes en recuperación quienes fueron azarosamente designados para recibir analgesia usando protocolos de dolor tanto con morfina como con la mezcla. Los grupos fueron bien compatibilizado por edad, peso y puntaje de dolor inicial.
Los resultados obtenidos evidenciaron que la media (SD) de tiempo para lograr el confort del pacientes fue 27.6 (20.2) minutos para la mezcla y 41.2 (18.6) minutos para morfina (p = 0.001). Por su parte, los análisis de regresión múltiple revelaron que el puntaje de dolor inicial (p = 0.009) y el grupo de drogas (p = 0.02), pero no así la edad, el peso y el género fueron predictores independientes del tiempo para lograr el confort. Finalmente, el grupo investigador concluyó que el grupo de drogas no resultó un predictor significativo de los efectos adversos.
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