El trabajo, que pretendía desentrañar el mecanismo que explica la posible asociación entre la mayor exposición a bacterias y la menor prevalencia de problemas alérgicos, demostró que este contacto aumenta la presencia de genes que codifican receptores de proteínas, como es el caso de CD14 y TLR2. Estas interacciones pueden modular la forma en la que el sistema inmunológico cumple sus funciones, alejándolo de aquello que causa la respuesta alérgica, explicaron los autores de la investigación.
Los expertos descubrieron “una presencia significativamente mayor” de los genes CD14 y TLR2 en 25 niños residentes en zonas no urbanas que en los 71 que vivían en ciudades, lo que sugiere “un vínculo entre la exposición a bacterias, la modulación del sistema inmunológico y la menor prevalencia de alergias” en los menores crecidos en el campo.
“Nuestros resultados apuntan a mecanismos que protegen a los niños residentes fuera de las ciudades contra el desarrollo de disfunciones alérgicas", manifestó el Dr. Josef Riedler, uno de los autores del estudio, señalando que nuevos descubrimientos sobre la naturaleza precisa de estas interacciones pueden “proporcionar pistas para potenciales estrategias para la prevención de la alergia”.
Webs Relacionadas
Lancet
http://www.thelancet.com/
Kinderspital Zürich
http://www.kispi.unizh.ch/
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