Las heparinas de bajo peso molecular (HBPM) pueden convertirse en el tratamiento de elección en la prevención del trombolembolismo en pacientes con cáncer, según se desprende de las conclusiones de un estudio aparecido en “Archives of Internal Medicine”.
En este estudio abierto, llevado a cabo por investigadores del Hospital Georges Pompidou de París (Francia), 145 pacientes con cáncer y trombolembolismo venoso fueron aleatorizados para recibir durante tres meses 1,5 mg/kg diarios de enoxaparina (una HBPM) o warfarina. El parámetro principal de evaluación fue la combinación de hemorragia mayor y tromboembolismo venoso recurrente.
De los 71 pacientes evaluables que recibieron warfarina, 15 (21%) experimentaron alguno de estos eventos, frente a siete (10,5%) entre los que recibieron enoxaparina. Se registraron seis muertes por hemorragia en el grupo warfarina y ninguna en el de la HBPM; la mortalidad por todas las causas fue del 22,7% con warfarina y 11,3% con enoxaparina. No hubo diferencias entre ambos grupos en cuanto al cáncer subyacente ni a la mortalidad relacionada con el mismo.
Webs Relacionadas
Hopital Européen Georges Pompidou
http://www.hbroussais.fr/
Archives of Internal Medicine
http://archinte.ama-assn.org/subs/login.html
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