En un estudio con ratones, han observado que una estatina concretamente la fluvastatina- reduce de forma significativa la extensión al hígado de las células tumorales pancreáticas. Sólo 10 de los 12 ratones tratados con esta estatina (83%) desarrollaron cáncer hepático, frente al 100% de los no tratados. Asimismo, el número de nódulos hepáticos cancerosos fue inferior entre los roedores que recibieron el fármaco.
Los autores creen que el efecto de las estatinas sobre este tipo de tumor tiene que ver con una acción dual de la enzima HGM-CoA reductasa. Además de ser necesaria para que el hígado produzca colesterol, también lo es para el adecuado funcionamiento del factor de crecimiento epidérmico, que ayuda a las células tumorales del páncreas a invadir otros órganos.
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Gastroenterology
http://www.gastrojournal.org/
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