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Un artículo publicado en "Annals of Internal Medicine" indica que la tasa de mortalidad por síndrome respiratorio agudo severo (SRAS) puede situarse en el 12% de los afectados por la enfermedad, cuando las estimaciones previas la situaban entre el 5 y el 10%.
Investigadores del Princess Margaret Hospital de Hong Kong han analizado datos de 267 pacientes consecutivos hospitalizados entre febrero y marzo por SRAS probable o confirmado. Los casos confirmados fueron 227 y los probables 40. Casi todos presentaban fiebre y otros síntomas frecuentes, entre ellos escalofríos, malestar y mialgia.
Los hallazgos de laboratorio muestran que el 73% de los pacientes presentaba linfopenia. También fueron frecuentes la trombocitopenia, la hiponatremia y los niveles elevados de lactato dehidrogenasa y proteína C reactiva.
Durante la hospitalización se registraron tasas elevadas de diarrea, anemia e insuficiencia renal aguda. Más de una cuarta parte de los pacientes necesitaron cuidados intensivos debido a insuficiencia respiratoria.
La tasa de mortalidad a los 3 meses del estudio fue del 12%. La edad superior a 60 años y la presencia de niveles elevados de lactato dehidrogenasa se identificaron como predictores independientes de mortalidad.