En este trabajo, que publica “Journal of Clinical Oncology”, señalan que el cáncer endometrial puede aparecer como un componente del cáncer colorrectal hereditario no polipósico que se relaciona con la deficiencia de estos genes. Siguieron a 519 pacientes consecutivas con cáncer endometrial durante 10 años, y registraron una incidencia del 2,1% de estas mutaciones, similar a la que se encuentra en pacientes diagnosticados de cáncer colorrectal. De este grupo, se identificaron 23 familias con cáncer endometrial solo, de las que sólo 2 tenían mutaciones germinales, lo que sugirió una etiología desconocida en la mayoría de familias.
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Journal of Clinical Oncology
Universidad de Helsinki
Medical News
/ Published on September 2, 2005
Riesgos familiares
La historia familiar puede no revelar el riesgo de cáncer endometrial
La predisposición genética al cáncer de endometrio debida a mutaciones germinales en los genes de reparación de los errores de replicación del ADN (“mismatch repair genes”) puede que no correlacione inmediatamente con la historia familiar, según un estudio de la Universidad de Helsinki (Finlandia).
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