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Científicos del Instituto Nacional del Cáncer de Estados Unidos llevaron a cabo la investigación con una muestra de 9.000 varones, que recibieron finasterida o placebo. Estaba prevista una duración de 10 años o hasta el año 2004.
Los resultados muestran que el 18% (803 en total) de los varones que recibieron finasterida desarrollaron cáncer de próstata, frente al 24% (1.147) de los que recibieron placebo.
La mayoría de los participantes presentaba niveles normales de antígeno específico de la próstata (PSA) y la exploración rectal también fue considerada normal en la mayor parte.
No obstante, se observó que, entre los varones que desarrollaron cáncer de próstata, aquellos que recibieron el fármaco presentaron formas más agresivas (6,4% del total de la muestra) que los del grupo placebo (5,1%). Los autores no tienen explicación clara sobre este punto y estudian varias posibilidades, entre ellas el hecho de que la finasterida afecta a la apariencia de las células tumorales y ello puede conducir a una falsa estimación del grado del tumor, que es determinado visualmente por el patólogo.
Webs Relacionadas
Información sobre Proscar (finasterida)
http://www.proscar.com/proscar_finasteride/proscar/consumer/index.jsp
Cancer National Institute
http://www.cancer.gov/templates/sysMsg.aspx?
New England Journal of Medicine
http://content.nejm.org/