La justificación del ensayo es que la mifepristona podría combatir determinados tumores ligándose a sus receptores de la hormona progesterona, así como bloqueando el crecimiento de nuevos vasos sanguíneos, necesarios para la supervivencia de las células tumorales. Asimismo, diversos estudios han demostrado previamente que mifepristona tiene cierto efecto en pacientes con cáncer de mama avanzado.
Las pacientes participantes padecen carcinoma endometrial recurrente y/o avanzado o sarcoma estromal endometrial de bajo grado, siendo un requisito que todas ellas tengan tumores positivos a los receptores de progesterona. Si la RU-486 muestra un beneficio en este tipo de tumores, se realizaran nuevos ensayos en cáncer de endometrio y en otros tipos de tumores con receptores hormonales, como los de ovario, próstata y mama.
Webs Relacionadas
MD Anderson Cancer Center
http://www.mdanderson.org/
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