Los autores publicaron en 2001 que una enzima llamada ACAT, que controla el almacenamiento del colesterol en la membrana celular, también parece regular la formación de proteína beta-amiloide.
Diseñaron un inhibidor de la enzima ACAT y han comprobado en ratones transgénicos que el fármaco reduce la formación de placa de amiloide en el cerebro, lo cual se asocia a una mayor capacidad de aprendizaje de los animales tratados respecto a los no tratados.
Webs Relacionadas
Neuron
http://www.neuron.org/
Massachusetts General Hospital
http://www.mgh.harvard.edu
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Publicado el 24 de octubre de 2004
Enfermedada de Alzheimer
Inhibición de la enzima ACAT y Alzheimer
Un fármaco experimental diseñado para reducir los niveles de colesterol posee un mecanismo de acción que también podría ser útil para tratar el Alzheimer. Investigadores del Massachusetts General Hospital de Boston publican sus resultados en "Neuron".
Los autores publicaron en 2001 que una enzima llamada ACAT, que controla el almacenamiento del colesterol en la membrana celular, también parece regular la formación de proteína beta-amiloide.
Diseñaron un inhibidor de la enzima ACAT y han comprobado en ratones transgénicos que el fármaco reduce la formación de placa de amiloide en el cerebro, lo cual se asocia a una mayor capacidad de aprendizaje de los animales tratados respecto a los no tratados.
Webs Relacionadas
Neuron
http://www.neuron.org/
Massachusetts General Hospital
http://www.mgh.harvard.edu