Las conclusiones del estudio se publican en la revista “Nature”. Según los científicos, los ratones creados para carecer de un cierto tipo de molécula conocida como receptor del ácido lisofosfatídico (LPA) presentan problemas de fertilidad, lo que sugiere que estos receptores juegan un importante papel en la concepción.
Los investigadores detallan en su estudio cómo los ratones que carecen de los receptores LPA, que normalmente se encuentran sobre la superficie de las células en el útero del ratón, tienen problemas de fertilidad.
Estos ratones son capaces de producir óvulos de forma normal y esos óvulos pueden ser fertilizados. Pero los embriones resultantes, que de otra manera serían saludables, tienen problemas para implantarse en el útero.
Este descubrimiento es significativo ya que las mujeres poseen también estos receptores LPA expresados en el útero. El descubrimiento de que los receptores LPA afectan a la fertilidad en ratones podría abrir una nueva área de investigación sobre la fertilidad y el tratamiento en humanos.
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Scripps Research Institute
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