La LLA supone el 23% de los diagnósticos de cáncer en niños de menos de 15 años. En Estados Unidos, el 80% de los 3.000 niños diagnosticados cada año pueden ser curados con una combinación de fármacos, pero el tratamiento fracasa en el 20% de casos.
En este trabajo, publicado en “The New England Journal of Medicine”, informan de la identificación de 124 genes que causan resistencia a los fármacos más empleados. Estos hallazgos provienen de estudios genéticos detallados de 271 pacientes tratados en varios centros estadounidenses.
Para los autores, los resultados de su estudio proporcionan una diana para el desarrollo de nuevos medicamentos que inhiban los productos de los genes que causan resistencia. Por otro lado, el estudio de las características genéticas de cada niño enfermo podrá determinar en el futuro un tratamiento individualizado que consiga reducir los efectos secundarios de la terapia intensiva de esta patología, que suele cursar con una elevada tasa de recurrencia.
Webs Relacionadas
St. Jude Children´s Research Hospital
http://www.stjude.org/
New England Journal of Medicine
http://content.nejm.org/
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