Llamado SLC5A8, este gen se halla desactivado en el 60% de los cánceres de colon. Su versión normal, tal como escriben los autores, suprime el crecimiento de los tumores, tanto en el laboratorio como en ratones. En el estudio observaron que la desactivación de este gen supresor tumoral constituye un evento temprano en el cáncer de colon humano.
También señalan que el gen transporta una sustancia, por el momento desconocida, dentro de las células del colon, unida al movimiento del sodio dentro de la célula. "En futuros estudios esperamos determinar la identidad de esta misteriosa sustancia, que podría ser una diana potencial para el desarrollo de nuevos fármacos antitumorales", concluyen.
Webs Relacionadas
Proceedings of the National Academy of Sciences
http://www.pnas.org/
Case Western Reserve University
http://www.cwru.edu/
![IntraMed](data:image/svg+xml,<?xml version="1.0" encoding="UTF-8"?>%0A<svg id="Capa_1" xmlns="http://www.w3.org/2000/svg" version="1.1" viewBox="0 0 1080 315">%0A <defs>%0A <style>%0A .st0 {%0A fill-rule: evenodd;%0A }%0A%0A .st0, .st1 {%0A fill: %23002bc7;%0A }%0A%0A .st2 {%0A fill: %23fff;%0A }%0A </style>%0A </defs>%0A <g>%0A <circle class="st2" cx="141.5" cy="179.93" r="135.02"/>%0A <g>%0A <path class="st2" d="M350.28,126.97v106.62c0,7-4.04,11.22-10.41,11.22s-10.5-4.22-10.5-11.22v-106.62c0-7,4.13-11.22,10.5-11.22s10.41,4.22,10.41,11.22Z"/>%0A <path class="st2" d="M459.96,184.86v49.09c0,6.82-4.04,10.86-10.23,10.86s-10.14-4.04-10.14-10.86v-47.03c0-13.28-6.73-20.28-20.73-20.28-7.81,0-15.53,2.15-20.19,4.85v62.47c0,6.82-4.04,10.86-10.23,10.86s-10.14-4.04-10.14-10.86v-66.68c0-6.37,1.35-9.24,7.09-12.21,5.38-3.14,18.49-8.17,33.48-8.17,26.66,0,41.11,14.36,41.11,37.96Z"/>%0A <path class="st2" d="M505.83,137.92v10.68h24.14c7,0,10.59,3.59,10.59,9.42s-3.59,9.33-10.59,9.33h-24.14v45.05c0,9.78,3.86,14.09,12.74,14.09,4.76,0,8.08-1.08,10.77-1.98,2.15-.72,3.95-1.52,6.28-1.52,4.58,0,8.44,3.77,8.44,9.06s-3.14,8.08-7.99,9.96c-5.21,1.97-11.76,3.59-18.76,3.59-19.03,0-31.86-10.86-31.86-31.23v-76.47c0-6.82,3.95-10.77,10.14-10.77s10.23,3.95,10.23,10.77Z"/>%0A <path class="st2" d="M559.96,233.95v-55.73c0-19.3,11.76-31.32,30.69-31.32,6.01,0,11.22.72,15.17,1.89,5.83,1.61,9.87,4.67,9.87,10.32,0,6.28-4.22,9.87-8.44,9.87-1.97,0-3.41-.36-4.85-.72-3.05-.81-5.92-1.26-9.69-1.26-8.44,0-12.39,4.04-12.39,12.39v54.57c0,6.82-3.95,10.86-10.14,10.86s-10.23-4.04-10.23-10.86Z"/>%0A <path class="st2" d="M624.04,214.83c0-15.08,11.76-28.9,36.08-28.9,7.81,0,14.72.99,22.89,3.14v-7.45c0-10.86-5.74-16.25-20.28-16.25-6.37,0-12.74,1.62-16.69,3.23-2.69.99-5.21,1.88-7.45,1.88-4.76,0-8.53-3.68-8.62-8.71,0-4.22,2.24-7.54,7.81-9.69,6.19-2.6,15.8-5.21,26.48-5.21,24.5,0,38.41,11.04,38.41,35.27v46.13c0,3.68-.99,5.56-3.77,7.45-5.65,3.86-19.57,9.87-37.87,9.87-23.78,0-36.98-13.37-36.98-30.78ZM662.73,228.84c7.27,0,14.81-2.06,20.28-4.94v-20.19c-7.45-2.24-13.55-3.23-20.37-3.23-12.83,0-19.21,6.28-19.21,14.36,0,8.89,7.54,14,19.3,14Z"/>%0A <path class="st2" d="M724.12,235.12c0-.81.09-2.06.18-2.78l13.73-96.57c2.15-15.17,9.51-20.01,20.1-20.01,9.51,0,16.78,3.95,19.66,19.12l18.4,85.71c.45,1.62.72,2.33,1.98,2.33,1.35,0,1.7-.72,2.06-2.42l18.31-85.62c2.87-15.17,10.05-19.12,19.57-19.12,10.68,0,17.95,4.85,20.01,20.1l13.73,96.03c.18,1.44.27,2.24.27,3.32,0,5.84-3.95,9.6-9.69,9.6-6.55,0-10.14-3.5-10.86-10.05l-12.12-94.86c-.27-1.89-.72-2.51-1.88-2.51-.99,0-1.53.45-1.88,2.15l-19.57,88.22c-2.42,11.58-8.53,17.05-18.13,17.05-10.23,0-15.71-5.57-18.22-17.14l-19.48-88.04c-.45-1.62-.99-2.24-1.79-2.24-1.17,0-1.71.72-1.97,2.6l-11.85,94.78c-.81,6.64-4.31,10.05-10.41,10.05s-10.14-3.59-10.14-9.69Z"/>%0A <path class="st2" d="M891.08,208.91c-.63-6.73-.63-17.68-.09-23.96,2.06-22.17,18.04-37.87,42.18-37.87s39.67,16.06,39.67,39.67v5.3c0,9.87-1.97,11.31-10.86,11.31h-51.88c0,1.26,0,2.6.09,3.86.72,12.03,9.96,20.01,24.32,20.01,7.9,0,13.91-1.71,18.85-3.68,2.96-1.08,4.85-2.06,7.45-2.06,4.85,0,8.44,3.14,8.44,8.44.09,5.12-3.77,8.08-7.54,9.78-6.91,3.32-16.78,5.92-27.64,5.92-24.5,0-41.01-15.08-42.99-36.71ZM954,188.81c1.26-15.44-7.81-24.32-21.45-24.32s-21.54,8.98-22.35,22.08c0,.72-.09,1.53-.09,2.24h43.89Z"/>%0A <path class="st2" d="M1074.18,125.17v102.85c0,3.95-1.08,5.92-3.86,7.81-5.83,3.86-20.1,9.78-37.16,9.78-23.87,0-39.22-14.81-41.19-36.17-.72-7.27-.72-19.21,0-26.39,1.97-21.36,17.32-36.17,39.4-36.17,8.17,0,16.78,2.06,22.44,4.85v-26.57c0-6.82,3.95-10.86,10.23-10.86s10.14,4.04,10.14,10.86ZM1033.97,225.87c6.91,0,15.53-2.06,19.83-5.11v-49c-4.31-3.05-12.93-5.12-19.83-5.12-13.37,0-20.73,7.99-21.81,19.75-.54,6.55-.45,13.82,0,19.74,1.08,11.76,8.44,19.75,21.81,19.75Z"/>%0A </g>%0A <g>%0A <path class="st1" d="M101.42,217.17c0-.64.07-1.63.14-2.2l10.87-76.46c1.71-12.01,7.53-15.85,15.92-15.85,7.53,0,13.29,3.13,15.56,15.14l14.57,67.86c.36,1.28.57,1.85,1.56,1.85,1.07,0,1.35-.57,1.63-1.92l14.5-67.79c2.27-12.01,7.96-15.14,15.49-15.14,8.46,0,14.21,3.84,15.85,15.92l10.87,76.04c.14,1.14.21,1.78.21,2.63,0,4.62-3.13,7.6-7.67,7.6-5.19,0-8.03-2.77-8.6-7.96l-9.59-75.11c-.21-1.49-.57-1.99-1.49-1.99-.78,0-1.21.36-1.49,1.71l-15.49,69.85c-1.92,9.17-6.75,13.5-14.36,13.5-8.1,0-12.44-4.41-14.43-13.57l-15.42-69.71c-.36-1.28-.78-1.78-1.42-1.78-.92,0-1.35.57-1.56,2.06l-9.38,75.04c-.64,5.26-3.41,7.96-8.24,7.96s-8.03-2.84-8.03-7.67Z"/>%0A <path class="st1" d="M90.62,131.29v84.42c0,5.54-3.2,8.88-8.24,8.88s-8.31-3.34-8.31-8.88v-84.42c0-5.54,3.27-8.88,8.31-8.88s8.24,3.34,8.24,8.88Z"/>%0A </g>%0A <g>%0A <path class="st0" d="M74.36,202.14c19.92.79,54.3-4.62,92.4-15.33,58-16.32,102.67-38.77,99.76-50.15-2-7.85-26.05-8.39-59.77-2.65,23.98-2.82,37.51-1.37,39.11,4.9,2.82,11.03-37.79,32.76-93.95,48.56-1.26.35-2.51.7-3.76,1.04,0,0,0,0-.01,0-13.29,3.95-50.37,13.62-73.78,13.62Z"/>%0A <path class="st0" d="M191.55,191.02c-13.03,4.75-27.19,9.32-42.09,13.5-70.38,19.79-130.56,23.59-134.41,8.48-2.65-10.4,20.1-26.01,58.76-41.85-26.73,12.73-38.09,24.13-35.96,32.45,3.73,14.63,59.37,10.95,127.5-8.22,36.59-10.29,68.58-22.95,89.79-34.73-9.63,6.73-23.48,14.01-40.32,21.2-4.91,2.44-18.07,7.34-23.28,9.16Z"/>%0A </g>%0A </g>%0A</svg>%0A)