De este modo, tal como publican en "Cell", han descubierto la capacidad supresora tumoral del gen en ratones, genéticamente manipulados para carecer de él. Estos roedores desarrollaron sobreabundancia de células en el epitelio gástrico, que además eran menos sensibles al factor de crecimiento que normalmente las inhibe.
Posteriormente, examinaron muestras humanas de tumores gástricos y observaron que el gen se encontraba desactivado en el 60% de ellas. En fases precoces de la enfermedad, el gen estaba desactivado en el 40% de los casos, pero la proporción alcanza cerca del 90% en estadios avanzados.
La buena noticia es que, además, consiguieron reactivar dicho gen en ratones utilizando inhibidores de la histona deacetilasa, lo cual condujo a una "dramática inhibición" del crecimiento tumoral.
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Cell
http://www.cell.com/
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