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El gen controla el crecimiento de la bacteria Mycobacterium tuberculosis en los pulmones, lo que según los autores, "constituye un importante paso adelante para comprender por qué algunos pacientes infectados son capaces de combatir la infección y otros no". "Este hallazgo –añaden- puede conducir a innovadoras estrategias de prevención y tratamiento para los 2 millones de pacientes que mueren anualmente por tuberculosis".
Los investigadores utilizaron un modelo de ratón y una técnica de exploración genómica para identificar el gen. Tras infectar a los roedores con la bacteria, compararon aquellos que desarrollaron la enfermedad con los que no hasta descubrir una variante genética en el cromosoma 19, llamada Trl-4, que parece ser la causa de que algunos animales sean susceptibles a desarrollar la enfermedad. Estos ratones presentaban mayor cantidad de bacterias en sus pulmones y murieron antes. "Creemos que esta variante genética –declaran los autores- controla el crecimiento de la bacteria en los pulmones. El siguiente paso es probar si este gen está presente en personas que son susceptibles a la enfermedad".
Webs Relacionadas
Proceedings of the National Academy of Sciences
http://www.pnas.org/
McGill University
http://www.mcgill.ca/