Añaden que los mismos genes están implicados en otros tipos de tumores, como los de mama y pulmón, tal como publican en "Science".
Según los autores, lo importante del hallazgo es haber descubierto mutaciones que afectan directamente al desarrollo tumoral, algo que no sucede en la mayor parte de identificaciones de genes relacionados con el cáncer.
Tras analizar 157 tumores de colon, encontraron 77 mutaciones en 6 genes que codifican las tirosín-fosfatasas, enzimas que participan en la coordinación de señales que regulan el crecimiento celular, la muerte, la diferenciación y la invasión de tejidos. Estas enzimas son supresores tumorales, pero no funcionan correctamente cuando los genes que las codifican presentan mutaciones.
Webs Relacionadas
Science
http://www.sciencemag.org/
Kimmel Cancer Center at Johns Hopkins
http://www.hopkinskimmelcancercenter.org
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