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Los autores, del Instituto Nacional sobre Envejecimiento (NIA) de Estados Unidos, se refieren al gen de la alfa-sinucleína. En concreto, han identificado una familia con enfermedad de Parkinson cuyos miembros afectados no son portadores de mutaciones en ese gen, sino que presentan una repetición anómala de copias del mismo. Por ello, explican que tener mucha más sinucleína de la normal conduce al desarrollo de la enfermedad.
En esta familia con genes de más, el inicio de la enfermedad fue más temprano y su progresión más rápida, con una tasa de demencia más elevada que en los casos esporádicos de Parkinson.
Webs Relacionadas
Science
http://www.sciencemag.org/
National Institute on Aging
http://www.nia.nih.gov/