Medical News
/ Published on March 3, 2002
Deterioro cognitivo
Gen de la APOE4 y pérdida de memoria
La variación genética conocida con APOE4 ha sido relacionada con la enfermedad de Alzheimer y con la patología cardíaca. Sin embargo, un nuevo estudio también la asocia a pérdida de memoria en personas sanas a medida que envejecen.
La investigación se llevó a cabo con 165 individuos sanos mayores de 55 años. Los autores, de la Universidad de Duke (Estados Unidos), mostraron en la reunión de la Asociación Americana de Psiquiatría Geriátrica, desarrollada en Orlando, que la actividad neuronal en la región frontal del cerebro declina a una velocidad tres veces mayor entre los portadores del gen de la APOE4 que en el resto. Concretamente, la actividad en esta zona cerebral implicada en la memoria disminuyó un 28% entre los individuos que tenían copias activas del gen de la APOE4, pro sólo un 9% entre los no portadores de la variante.
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