La combrestatina A4 fosfato parece prevenir la pérdida de visión en pacientes con degeneración macular miópica, sin que se hayan registrado efectos adversos graves, según los resultados preliminares de un ensayo en fase II, de acuerdo con la información facilitada por la compañía Oxigene, elaboradora del fármaco.
En un estudio multicéntrico, dosis-respuesta y doble enmascarado, realizado, se les administró a 23 personas tal fármaco por vía venosas a dosis de 27, 36 y 45 mg/m2. Todos los pacientes recibieron tres dosis, durante una semana aparte, con hasta tres dosis adicionales.
A los tres meses de seguimiento, los resultados mostraron la eficacia del fármaco, ya que el 100% de los pacientes perdieron menos de tres líneas de agudeza visual.
La compañía ha anunciado su intención de desarrollar el fármaco en gotas oculares, después de una reunión con la FDA de Estados Unidos.
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