La exposición acumulativa a eritropoyetina recombinante en niños nacidos prematuramente se asocia con un incremento de riesgo de retinopatía de prematuridad (ROP), de acuerdo con un estudio de casos del Presbyterian/St Luke’s Medical Center, de Denver (Estados Unidos), que publica “Journal of the American Association for Pedriatic Ophthalmology and Strabismus” (JAAPOS).
Los autores compraron los registros de 327 niños, que nacieron en un período de cuatro años. El parto se produjo tras 30 semanas de gestación o más pronto. Tenían un peso menor de los 1.500 g y sobrevivieron. A las seis semanas del nacimiento, se les hizo una examen ocular. Durante el período del estudio, a todos los niños se les administró eritropoyetina recombinante.
La incidencia total de la ROP fue del 36%. La exposición a la eritropoyetina recombinante se relacionó con un aumento de riesgo de progresión de la retinopatía.
Los investigadores sugieren que las propiedades no hematopoyéticas del fármaco puede ser la causa de esta situación.
JAAPOS 2006;10:143-149
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