Científicos canadienses de la Universidad de Saskatchewan publican en el "Journal of General Virology" que utilizando células inmunitarias con una proteína obtenida del virus de la hepatitis C han podido inducir respuestas inmunitarias en un modelo animal de hepatitis C.
Los autores explican que existe evidencia de que la función de las células dendríticas está alterada en pacientes con infección crónica por el virus de la hepatitis C.
Con intención de incrementar la actividad inmunitaria de estas células, los investigadores generaron células dendríticas en la médula ósea de ratones y las combinaron con un proteína del virus llamada NS3.
Los ratones no desarrollaron infección por el virus de la hepatitis C, por lo que los investigadores emplearon un virus vaccinia genéticamente modificado que expresara la proteína NS3 para infectar a los animales.
Todos los ratones a los que se administró la combinación de células dendríticas con NS3 mostraron una reducción en los niveles del virus vaccinia. Los autores concluyen que su estudio "proporciona una novedosa estrategia de vacunación contra la hepatitis B que podría ensayarse en seres humanos en el futuro".
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Journal of General Virology
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