El ácido fólico, pertenece al grupo de vitaminas B, es hidrosoluble, y hasta el momento no ha presentado toxicidad. Por ser un nutriente esencial no puede ser sintetizado por el hombre, incorporándolo al organismo mediante la dieta.
Mecanismo de Acción
Los folatos poseen dos efectos fisiológicos importantes: actúan como cofactor para enzimas que sintetizan ADN y ARN; y son necesarios para la transformación de homocisteína en metionina. La hiperhomocisteinemia constituye un factor de riesgo para patologías cardiovasculares.
Durante la embriogénesis, los requerimientos de folatos son máximas. La deficiencia de ácido fólico inhibe la síntesis de ácidos nucleicos, y las células no pueden producir ADN para la mitosis.
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Published on December 4, 2001
Medicina preventiva
El ácido fólico en la prevención de defectos congénitos
Actualmente se conoce que su déficit se asocia a patologías frecuentes como malformaciones congénitas y enfermedades cardiovasculares
Author: Dra. Beatriz Minoli
El ácido fólico, pertenece al grupo de vitaminas B, es hidrosoluble, y hasta el momento no ha presentado toxicidad. Por ser un nutriente esencial no puede ser sintetizado por el hombre, incorporándolo al organismo mediante la dieta.
Los folatos poseen dos efectos fisiológicos importantes: actúan como cofactor para enzimas que sintetizan ADN y ARN; y son necesarios para la transformación de homocisteína en metionina. La hiperhomocisteinemia constituye un factor de riesgo para patologías cardiovasculares.