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La eficacia terapéutica del antagonista de los receptores de angiotensina II, Losartan, fue estudiada en pacientes con esteatohepatitis sin alcohol (NASH).
Siete pacientes con NASH e hipertensión arterial fueron tratados con Losartan (50 mg/día) por 48 semanas.
El tratamiento con Losartan dió lugar a una disminución significativa de los marcadores sanguíneos de fibrosis hepática, de TGF-beta 1 y de la concentración de la ferritina del suero concomitantemente con una mejoría en los niveles de aminotransferasa del suero.
La evaluación histológica mostró una mejoría de la necroinflammacion hepática en cinco pacientes, la reducción de la fibrosis hepática en cuatro pacientes, y la desaparición de los depósitos de hierro en dos pacientes. No se observó ningún efecto secundario durante el estudio. En conclusión, los actuales datos aumentan la posibilidad que un antagonista de los receptores de la angiotensina II pueda ser terapéuticamente eficaz para el tratamiento del NASH.
(HEPATOLOGY 2004.)