Medical News
/ Published on May 28, 2001
Micofenolato mofetil
Combinación de inmunosupresores minimiza el riesgo de rechazo
El estudio revela que los corticoides o el micofenolato mofetil (MMF) pueden retirarse a los tres meses si se está tratando al paciente con una terapia inmunosupresora triple.
Kaija Salmela, del Hospital Universitario de Helsinki, en Finlandia, ha presentado los resultados de una investigación realizada en pacientes que han sido sometidos a un trasplante de riñón. El estudio revela que los corticoides o el micofenolato mofetil (MMF) pueden retirarse a los tres meses si se está tratando al paciente con una terapia inmunosupresora triple.
El trabajo se llevó a cabo en 47 centros especializados en trasplantes renales, entre los que se reclutó a 833 pacientes para llevar a cabo este estudio abierto con grupos paralelos y de seis meses de duración. El propósito era comparar los resultados con triple terapia, compuesta por tacrolimus, MMF y esteroides, con la retirada a los tres meses de los esteroides o del micofenolato mofetil.
Basándose en los resultados, Salmela hizo hincapié en que la retirada precoz de los esteroides o del micofenolato mofetil en pacientes sometidos a trasplante de riñón fue eficaz y bien tolerada utilizando tacrolimus como base del tratamiento inmunosupresor.
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