Estudio de cohortes retrospectivo donde se siguieron 11,554 participantes de la encuesta nutricional en Canadá (1970-1972) hasta 1993. Hubo 27 sujetos que cometieron suicidio.
Los investigadores canadienses compararon el riesgo de suicidio a diferentes niveles de colesterol sérico tomando como base el quartil más alto. Ellos observaron que el riesgo de suicidio es de 6.39 cuando las cifras de colesterol están en el quartil más bajo, 2.95 en el segundo quartil, 1.94 en el tercer quartil. Estos riesgos se mantienen después de excluir pacientes con depresión clínica y desempleados.
Los mecanismos propuestos para explicar esta asociación son: (1) el bajo colesterol podría causar bajos niveles de serotonina, (2) puede ser consecuencia de la depresión o (3) los niveles elevados de interleucina-2 pueden ser causa de colesterol bajo y baja melatonina.
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