La ciclosporina inhalada incrementa dramáticamente la supervivencia de los trasplantados pulmonares. Así lo muestra un estudio publicada en "The New England Journal of Medicine" por investigadores de la Universidad de Maryland (Estados Unidos).
Se trata del primer ensayo doble ciego y controlado con placebo en el que se evalúa la ciclosporina inhalada en receptores de un trasplante de pulmón. Realizado entre 1998 y 2001, sus resultados muestran que aquellos pacientes que recibieron este inmunosupresor presentaron un riesgo de rechazo crónico en dos tercios en comparación a placebo.
Tras ajustar distintas variables, se observó que el riesgo de muerte fue cinco veces superior en el grupo placebo que el tratado con la ciclosporina inhalada.
En la investigación participaron 56 pacientes sometidos a trasplante pulmonar simple o doble que recibieron terapia inmunosupresora habitual además de la ciclosporina o el placebo.
New England Journal of Medicine 2006;354:141-150
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