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En este sentido, el 65% de los 811 pacientes (de 14 a 79 años) con epilepsia crónica , que no habían respondido a otros tratamientos, continuaron utilizando levetiracetam (125-5.000 mg/día; media de 2.000 mg/día) durante periodos superiores a 41 meses. El 18% de los pacientes no sufrió ninguna nueva crisis para periodos de tratamiento de 1-35 meses (11 meses de media); un 29% consiguió una reducción por encima del 50% en la frecuencia de sus crisis; y un 47% experimentó una reducción significativa de sus crisis.
Cuarenta y seis pacientes que participaron en este estudio pudieron controlar su epilepsia con monoterapia de levetiracetam (Keppra, UCB Pharma). De ellos, 26 consiguieron periodos libres de crisis de 2-35 meses (con una media de 13 meses). La tasa de abandono del tratamiento fue del 33%, una tasa muy inferior a la que se produce a tan largo plazo con otros fármacos antiepilépticos (que va del 70% al 90%), causada en el caso de levetiracetam por una falta de eficacia (14%), efectos secundarios (10%) o una combinación de ambos motivos (9%).
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