Estudio prospectivo de cohortes donde se estudiaron 46 sujetos sanos y 31 pacientes con asma moderada a severa.
Los investigadores británicos midieron todos los metabolitos de cortisol (TCM) en orina - una prueba considerablemente más sensible para valorar los efectos sistémicos que el cortisol en ayunas o la osteocalcina - en individuos sanos y asmáticos al inicio y 7 días después de recibir al azar:
(1) fluticasona 1500 mcg/d, (2) budesonida 1600 mcg/d o (3) placebo (los asmáticos no recibieron placebo) y observaron que los sujetos sanos tuvieron en el principio niveles más altos de TCM que los asmáticos y después de 7 días los sanos del grupo (1) tenían niveles significativamente más bajos de TCM que los asmáticos.
Los investigadores esperan con ello explicar las discrepancias en la literatura con respecto a los efectos sistémicos de fluticasona.
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