En el estudio randomizado SEARCH (Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine) realizado sobre una población de 12.064 personas, el empleo de 2 mg de Ácido Fólico (Vitamina B9) y 1 mg de Vitamina B12 resultó ineficaz para el objetivo de reducir los eventos cardiovasculares mayores comparado con placebo.
Las vitaminas no incrementaron la incidencia de muerte no cardiovascular o cáncer durante un seguimiento promedio de 6.7 años de la población de pacientes que habían sufrido un episodio cardíaco previamente.
Según lo afirmado por la investigadora inglesa Jane M. Armitage University of Oxford, esto resulta importante ya que varios países como Canadá y EEUU emplean la fortificación con Ácido Fólico de harinas, pan y cereales con el propósito de reducir la incidencia de los defectos del tubo neural en neonatos.
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