La neurogénesis es seguida de la diferenciación, migración y el establecimiento de una diana postsináptica, un proceso que puede tardar semanas en completarse y que podría explicar el retraso en el inicio de una acción eficaz de estos fármacos antidepresivos. El Dr. Ren Hen, autor principal del estudio, señala que “interviniendo en la cascada de eventos que conducen a la neurogénesis podríamos encontrar nuevos agentes con un inicio de acción más rápido y menores efectos secundarios que los antidepresivos actuales”.
En este estudio, desarrollado en la Universidad de Columbia en Nueva York (Estados Unidos), los investigadores vieron que la administración de fluoxetina a ratones durante de 11 a 28 días causaba un 60% de incremento del número de células progenitoras, mientras que la administración durante cinco días no tenía efecto alguno.
Webs Relacionadas
Science
http://www.sciencemag.org/
Columbia University
http://www.columbia.edu/
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