El hallazgo, que será presentado en una rueda de prensa en la que participará el consejero de Sanidad de Madrid, Manuel Lamela, supone una nueva forma más natural, menos agresiva y más específica de combatir desde el propio organismo cualquier tipo de cáncer.
Los científicos, que han publicado sus conclusiones en el último número del "Journal of Inmmunology", han utilizado la técnica del silenciamiento genético, que consiste en desactivar la molécula que frena las defensas naturales para reactivar el sistema inmune.
La investigación ha sido liderada por el Dr. Eduardo López-Collazo, parte de la base de que los macrófagos de la sangre que poseen actividad citotóxica contra las células tumorales, se hallan normalmente desactivados en los pacientes de cáncer. De hecho, estos macrófagos expuestos a células tumorales muestran niveles decrecientes del factor de necrosis tumoral alfa (TNF-alfa), la interleucina IL-12p40 y la cinasa asociada Il-1R (IRAK-1).
Por el contrario, los científicos constatan que otra cinasa de la misma familia, la IRAK-M, sigue una pauta distinta reforzándose en el ARN y las proteínas en los macrófagos humanos cultivados en presencia de células tumorales. De hecho, los macrófagos sanguíneos de pacientes con leucemia mieloide crónica metástasis tienen sobreexpresada la IRAK-M.
Webs Relacionadas
Journal of Immunology
Hospital Universitario La Paz
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