Una puesta al día fundamental | 22 JUN 21

Hiperinsulinismo congénito

Actualización sobre patogenia, diagnóstico y manejo del hiperinsulinismo congénito
Autor/a: Kathryn Sims NeoReviews 2021;22;e230
INDICE:  1. Texto principal | 2. Referencias bibliográficas
Referencias bibliográficas


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3. Aynsley-Green A, Hussain K, Hall J, et al. Practical management of hyperinsulinism in infancy. Arch Dis Child Fetal Neonatal Ed. 2000;82(2):F98–F107

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8. Giurgea I, Sempoux C, Bellanné-Chantelot C, et al. The Knudson’s two-hit model and timing of somatic mutation may account for the phenotypic diversity of focal congenital hyperinsulinism. J Clin Endocrinol Metab. 2006;91(10):4118–4123

9. de Lonlay P, Fournet JC, Rahier J, et al. Somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy. J Clin Invest. 1997;100(4):802–807

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in neonates, infants, and children. J Pediatr. 2015;167(2): 238–245

19. Yorifuji T, Horikawa R, Hasegawa T, et al; (on behalf of The Japanese Society for Pediatric Endocrinology and The Japanese Society of Pediatric Surgeons). Clinical practice guidelines for

congenital hyperinsulinism. Clin Pediatr Endocrinol. 2017;26(3):127–152

20. Nessa A, Rahman SA, Hussain K. Hyperinsulinemic hypoglycemia - the molecular mechanisms. Front Endocrinol (Lausanne). 2016;7:29 [Lausanne]

21. Calabria AC, Li C, Gallagher PR, Stanley CA, De León DD. GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism owing to inactivating mutations in the ATP-sensitive Kþ channel. Diabetes. 2012;61(10):2585–2591

22. Ackermann AM, Palladino AA. Managing congenital hyperinsulinism: improving outcomes with a multidisciplinary approach. Res Rep Endocr Disord. 2015;5:103–117

23. Pagana KD, Pagana TJ, Pagana TN. Mosby’s Diagnostic and Laboratory Test Reference. 15th ed. Philadelphia: Elsevier Inc; 2020



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