Inflamación, insuficiencia orgánica, mal pronóstico | 20 JUL 20

Insuficiencia hepática aguda sobre crónica

Evidencia que apoya el concepto de insuficiencia hepática aguda sobre crónica y controversias de aquellos que dudan de la existencia del síndrome.
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Autor/a: Vicente Arroyo, Richard Moreau, Rajiv Jalan.  N Engl J Med 2020;382:2137-45
INDICE:  1. Texto principal | 2. Referencias bibliográficas
Referencias bibliográficas

1. Moreau R, Jalan R, Ginès P, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology 2013; 144(7): 1426-37.

2. Sarin SK, Choudhury A, Sharma MK, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL): an update. Hepatol Int 2019; 13: 353-90.

3. Jalan R, Williams R. Acute-on-chronic liver failure: pathophysiological basis of therapeutic options. Blood Purif 2002; 20:252-61.

4. Jalan R, Saliba F, Pavesi M, et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol 2014; 61: 1038-47.

5. Li H, Chen LY, Zhang NN, et al. Characteristics, diagnosis and prognosis of acute-on-chronic liver failure in cirrhosis associated to hepatitis B. Sci Rep 2016; 6:25487.

6. Kim TY, Song DS, Kim HY, et al. Characteristics and discrepancies in acuteon- chronic liver failure: need for a unified definition. PLoS One 2016; 11(1): e0146745.

7. Wu T, Li J, Shao L, et al. Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acuteon-chronic liver failure. Gut 2018; 67:2181-91.

8. Mahmud N, Kaplan DE, Taddei TH, Goldberg DS. Incidence and mortality of acute-on-chronic liver failure using two definitions in patients with compensated cirrhosis. Hepatology 2019; 69: 2150-63.

9. Hernaez R, Kramer JR, Liu Y, et al. Prevalence and short-term mortality of acute-on-chronic liver failure: a national cohort study from the USA. J Hepatol 2019; 70: 639-47.

10. Gustot T, Fernandez J, García E, et al. Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis. Hepatology 2015; 62: 243-52.

11. Clària J, Stauber RE, Coenraad MJ, et al. Systemic inflammation in decompensated cirrhosis: characterization and role in acute-on-chronic liver failure. Hepatology 2016; 64: 1249-64.

12. Bajaj JS, O’Leary JG, Reddy KR, et al. Survival in infection-related acute-onchronic liver failure is defined by extrahepatic organ failures. Hepatology 2014; 60:250-6.

13. O’Leary JG, Reddy KR, Garcia-Tsao G, et al. NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis. Hepatology 2018; 67: 2367-

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14. Sarin SK, Kumar A, Almeida JA, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol Int 2009; 3: 269-82.

15. Sarin SK, Kedarisetty CK, Abbas Z, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014. Hepatol Int 2014; 8:453-71.

16. Chen T, Yang Z, Choudhury AK, et al. Complications constitute a major risk factor for mortality in hepatitis B virus-related acute-on-chronic liver failure patients: a multi-national study from the Asia-Pacific region. Hepatol Int 2019; 13: 695-705.

17. Amarapurkar D, Dharod MV, Chandnani M, et al. Acute-on-chronic liver failure: a prospective study to determine the clinical profile, outcome, and factors predicting mortality. Indian J Gastroenterol 2015; 34: 216-24.

18. Bernsmeier C, Pop OT, Singanayagam A, et al. Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK. Gastroenterology 2015; 148(3): 603-615.e14.

19. Fernández J, Acevedo J, Wiest R, et al. Bacterial and fungal infections in acuteon- chronic liver failure: prevalence, characteristics and impact on prognosis. Gut 2018; 67: 1870-80.

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22. Cárdenas A, Ginès P, Uriz J, et al. Renal failure after upper gastrointestinal bleeding in cirrhosis: incidence, clinical course, predictive factors, and shortterm prognosis. Hepatology 2001; 34:671-6.

23. Fernández J, Clària J, Amorós A, et al. Effects of albumin treatment on systemic and portal hemodynamics and systemic inflammation in patients with decompensated cirrhosis. Gastroenterology 2019;157: 149-62.

24. Ginès P, Schrier RW. Renal failure in cirrhosis. N Engl J Med 2009; 361: 1279-90.

25. Piano S, Schmidt HH, Ariza X, et al. Association between grade of acute on chronic liver failure and response to terli-pressin and albumin in patients with hepatorenal syndrome. Clin Gastroenterol

Hepatol 2018; 16(11): 1792-1800.e3.

26. Moreau R, Clària J, Aguilar F, et al. Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF. J Hepatol 2020; 72: 688-701.

27. Garcia-Tsao G, Bosch J. Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med 2010; 362: 823-32.

28. Nadim MK, Durand F, Kellum JA, et al. Corrigendum to “Management of the critically ill patients with cirrhosis: a multidisciplinary perspective.” J Hepatol 2016;64: 717-35.

29. Sersté T, Cornillie A, Njimi H, et al. The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis. J Hepatol 2018; 69: 318-24.

30. Romero-Gómez M, Montagnese S, Jalan R. Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure. J Hepatol 2015; 62: 437-47.

31. Kribben A, Gerken G, Haag S, et al. Effects of fractionated plasma separation and adsorption on survival in patients with acute-on-chronic liver failure. Gastroenterology 2012; 142(4): 782-789.e3.

32. Bañares R, Nevens F, Larsen FS, et al. Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: the RELIEF trial. Hepatology 2013; 57: 1153-62.

33. Thompson J, Jones N, Al-Khafaji A, et al. Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: a multinational, prospective, controlled, randomized trial. Liver Transpl 2018; 24: 380-93.

34. Artru F, Louvet A, Ruiz I, et al. Liver transplantation in the most severely ill cirrhotic patients: a multicenter study in acute-on-chronic liver failure grade 3. J Hepatol 2017; 67: 708-15.

35. Sundaram V, Jalan R, Wu T, et al. Factors associated with survival of patients with severe acute-on-chronic liver failure before and after liver transplantation. Gastroenterology 2019; 156(5): 1381-1391.e3.

36. Thuluvath PJ, Thuluvath AJ, Hanish S, Savva Y. Liver transplantation in patients with multiple organ failures: feasibility and outcomes. J Hepatol 2018; 69: 1047-56.

 

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