1. Leon LR, Bouchama A. Heat stroke. Compr Physiol 2015; 5: 611-47.
2. Bouchama A, Knochel JP. Heatstroke. N Engl J Med 2002; 346: 1978-88.
3. Shapiro Y, Seidman DS. Field and clinical observations of exertional heatstroke patients. Med Sci Sports Exerc 1990; 22: 6-14.
4. Bouchama A, Dehbi M, Mohamed G, Matthies F, Shoukri M, Menne B. Prognostic factors in heat wave related deaths: a meta-analysis. Arch Intern Med 2007; 167: 2170-6.
5. Kravchenko J, Abernethy AP, Fawzy M, Lyerly HK. Minimization of heat wave morbidity and mortality. Am J Prev Med 2013; 44: 274-82.
6. Office of Climate, Water, and Weather Services. Weather fatalities 2018. Silver Spring, MD: National Weather Service, April 2019 (http://www .nws.noaa .gov/ om/hazstats.shtml).
7. Kenney WL, Craighead DH, Alexander LM. Heat waves, aging, and human cardiovascular health. Med Sci Sports Exerc 2014; 46: 1891-9.
8. Li L, Mac-Mary S, Sainthillier JM, Nouveau S, de Lacharriere O, Humbert P. Age-related changes of the cutaneous microcirculation in vivo. Gerontology 2006; 52: 142-53.
9. Anderson RK, Kenney WL. Effect of age on heat-activated sweat gland density and flow during exercise in dry heat. J Appl Physiol (1985) 1987; 63: 1089-94.
10. Fouillet A, Rey G, Laurent F, et al. Excess mortality related to the August 2003 heat wave in France. Int Arch Occup Environ Health 2006; 80: 16-24.
11. Åström DO, Forsberg B, Rocklöv J. Heat wave impact on morbidity and mortality in the elderly population: a review of recent studies. Maturitas 2011; 69: 99-105.
12. Heat-related deaths — United States, 1999–2003. MMWR Morb Mortal Wkly Rep 2006; 55: 796-8.
13. Falk B, Dotan R. Children’s thermoregulation during exercise in the heat: a revisit. Appl Physiol Nutr Metab 2008; 33: 420-7.
14. Booth JN III, Davis GG, Waterbor J, McGwin G Jr. Hyperthermia deaths among children in parked vehicles: an analysis of 231 fatalities in the United States, 1999-2007. Forensic Sci Med Pathol 2010; 6: 99-105.
15. Epstein Y, Moran DS, Shapiro Y, Sohar E, Shemer J. Exertional heat stroke: a case series. Med Sci Sports Exerc 1999; 31: 224-8.
16. Hosokawa Y, Adams WM, Belval LN, et al. Exertional heat illness incidence and on-site medical team preparedness in warm weather. Int J Biometeorol 2018; 62: 1147-53.
17. Rav-Acha M, Hadad E, Epstein Y, Heled Y, Moran DS. Fatal exertional heat stroke: a case series. Am J Med Sci 2004; 328: 84-.
18. Epstein Y. Heat intolerance: predisposing factor or residual injury? Med Sci Sports Exerc 1990; 22: 29-35.
19. O'Connor FG, Heled Y, Deuster PA. Exertional heat stroke, the return to play decision, and the role of heat tolerance testing: a clinician’s dilemma. Curr Sports Med Rep 2018; 17: 244-8.
20. Nadesan K, Kumari C, Afiq M. Dancing to death: a case of heat stroke. J Forensic Leg Med 2017; 50: 1-5.
21. Reardon CL, Creado S. Drug abuse in athletes. Subst Abuse Rehabil 2014; 5: 95- 105.
22. Abriat A, Brosset C, Brégigeon M, Sagui E. Report of 182 cases of exertional heatstroke
in the French Armed Forces. Mil Med 2014; 179: 309-14.
23. Kerr ZY, Marshall SW, Coms tock RD, Casa DJ. Implementing exertional heat illness prevention strategies in US high school football. Med Sci Sports Exerc 2014; 46: 124-30.
24. Armed Forces Health Surveillance Branch. Update: heat illness, active component, U.S. Armed Forces, 2017. MSMR 2018; 25: 6-12.
25. Epstein Y, Roberts WO. The Pathophysiology of heat stroke: an integrative view of the final common pathway. Scand J Med Sci Sports 2011; 21: 742-8.
26. Roberts GT, Ghebeh H, Chishti MA, et al. Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model. Arterioscler Thromb Vasc Biol 2008; 28: 1130-6.
27. Lim CL. Heat sepsis precedes heat toxicity in the pathophysiology of heat stroke — a new paradigm on an ancient disease. Antioxidants (Basel) 2018; 7(11): E149.
28. Yang YL, Lin MT. Heat shock protein expression protects against cerebral ischemia and monoamine overload in rat heatstroke. Am J Physiol 1999; 276: H1961-H1967.
29. Yan YE, Zhao YQ, Wang H, Fan M. Pathophysiological factors underlying heatstroke. Med Hypotheses 2006; 67: 609-17.
30. Dehbi M, Baturcam E, Eldali A, et al. Hsp-72, a candidate prognostic indicator of heatstroke. Cell Stress Chaperones 2010; 15: 593-603.
31. Leon LR, Helwig BG. Heat stroke: role of the systemic inflammatory response. J Appl Physiol (1985) 2010; 109: 1980-8.
32. Bouchama A, Roberts G, Al Mohanna F, et al. Inflammatory, hemostatic, and clinical changes in a baboon experimental model for heatstroke. J Appl Physiol (1985) 2005; 98: 697-705.
33. Huisse MG, Pease S, Hurtado-Nedelec M, et al. Leukocyte activation: the link between inflammation and coagulation during heatstroke — a study of patients during the 2003 heat wave in Paris. Crit Care Med 2008; 36: 2288-95.
34. Caserta S, Mengozzi M, Kern F, Newbury SF, Ghezzi P, Llewelyn MJ. Severity of systemic inflammatory response syndrome affects the blood levels of circulating inflammatory-relevant microRNAs. Front Immunol 2018; 8: 1977.
35. Hifumi T, Kondo Y, Shimizu K, Miyake Y. Heat stroke. J Intensive Care 2018; 6: 30.
36. Zeller L, Novack V, Barski L, Jotkowitz A, Almog Y. Exertional heatstroke: clinical characteristics, diagnostic and therapeutic considerations. Eur J Intern Med 2011; 22: 296-9.
37. Hall DM, Buettner GR, Oberley LW, Xu L, Matthes RD, Gisolfi CV. Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia. Am J Physiol Heart Circ Physiol 2001; 280: H509-H521.
38. Snipe RMJ, Khoo A, Kitic CM, Gibson PR, Costa RJS. The impact of exertional heat stress on gastrointestinal integrity, gastrointestinal symptoms, systemic endotoxin and cytokine profile. Eur J Appl Physiol 2018; 118: 389-400.
39. Brock-Utne JG, Gaffin SL, Wells MT, et al. Endotoxaemia in exhausted runners after a long-distance race. S Afr Med J 1988; 73: 533-6.
40. Epstein Y, Hadad E, Shapiro Y. Pathological factors underlying hyperthermia. J Therm Biol 2004; 29: 487-94.
41. Malamud N, Haymaker W, Custer RP. Heat stroke; a clinico-pathologic study of 125 fatal cases. Mil Surg 1946; 99: 397- 449.
42. Mazerolle SM, Ganio MS, Casa DJ, Vingren J, Klau J. Is oral temperature an accurate measurement of deep body temperature? A systematic review. J Athl Train 2011; 46: 566-73.
43. Maron MB, Wagner JA, Horvath SM. Thermoregulatory responses during competitive
marathon running. J Appl Physiol Respir Environ Exerc Physiol 1977; 42: 909- 14.
44. Albukrek D, Bakon M, Moran DS, Faibel M, Epstein Y. Heat-stroke-induced cerebellar atrophy: clinical course, CT and MRI findings. Neuroradiology 1997; 39: 195-7.
45. Yang M, Li Z, Zhao Y, et al. Outcome and risk factors associated with extent of central nervous system injury due to exertional heat stroke. Medicine (Baltimore) 2017; 96(44): e8417.
46. Wallace RF, Kriebel D, Punnett L, Wegman DH, Amoroso PJ. Prior heat illness hospitalization and risk of early death. Environ Res 2007; 104: 290-5.
47. Tong HS, Tang YQ, Chen Y, Qiu JM, Wen Q, Su L. Early elevated HMGB1 level predicting the outcome in exertional heatstroke. J Trauma 2011; 71: 808-14.
48. Segev G, Daminet S, Meyer E, et al. Characterization of kidney damage using several renal biomarkers in dogs with naturally occurring heatstroke. Vet J 2015; 206: 231-5.
49. Mellor PJ, Mellanby RJ, Baines EA, Villiers EJ, Archer J, Herrtage ME. High serum troponin I concentration as a marker of severe myocardial damage in a case of suspected exertional heatstroke in a dog. J Vet Cardiol 2006; 8: 55-62.
50. Bruchim Y, Avital Y, Horowitz M, Mazaki-Tovi M, Aroch I, Segev G. Urinary heat shock protein 72 as a biomarker of acute kidney injury in dogs. Vet J 2017; 225: 32-4.
51. Bruchim Y, Ginsburg I, Segev G, et al. Serum histones as biomarkers of the severity of heatstroke in dogs. Cell Stress Chaperones 2017; 22: 903-10.
52. Ji J, Gu Z, Li H, Su L, Liu Z. Cryptdin-2 predicts intestinal injury during heat-stroke in mice. Int J Mol Med 2018; 41: 137-46.
53. Casa DJ, McDermott BP, Lee EC, Yeargin SW, Armstrong LE, Maresh CM. Cold water immersion: the gold standard for exertional heatstroke treatment. Exerc Sport Sci Rev 2007; 35: 141-9.
54. McDermott BP, Casa DJ, Ganio MS, et al. Acute whole-body cooling for exercise induced hyperthermia: a systematic review. J Athl Train 2009; 44: 84-93.
55. Heled Y, Rav-Acha M, Shani Y, Epstein Y, Moran DS. The “golden hour” for heatstroke
treatment. Mil Med 2004; 169: 184-6.
56. Bouchama A, Dehbi M, Chaves- Carballo E. Cooling and hemodynamic management in heatstroke: practical recommendations. Crit Care 2007; 11(3): R54.
57. Chen CM, Hou CC, Cheng KC, Tian RL, Chang CP, Lin MT. Activated protein C therapy in a rat heat stroke model. Crit Care Med 2006; 34: 1960-6.
58. Pechlaner C, Kaneider NC, Djanani A, Sandhofer A, Schratzberger P, Patsch JR. Antithrombin and near-fatal exertional heat stroke. Acta Med Austriaca 2002; 29: 107-11.
59. Vincent JL, Ramesh MK, Ernest D, et al. A randomized, double-blind, placebo controlled,
phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med 2013; 41: 2069-79.
60. DeLano FA, Hoyt DB, Schmid-Schönbein GW. Pancreatic digestive enzyme blockade in the intestine increases survival after experimental shock. Sci Transl Med 2013; 5: 169ra11.
61. Wan Y, Sun SS, Fu HY, et al. Adjuvant rhubarb alleviates organs dysfunction and inhibits inflammation in heat stroke. Exp Ther Med 2018; 16: 1493-8.
62. Hajat S, O’Connor M, Kosatsky T. Health effects of hot weather: from awareness of risk factors to effective health protection. Lancet 2010; 375: 856-63.
63. O’Connor FG, Casa DJ, Bergeron MF, et al. American College of Sports Medicine Roundtable on exertional heat stroke — return to duty/return to play: conference proceedings. Curr Sports Med Rep 2010; 9: 314-21.
64. Armstrong LE, Casa DJ, Millard-Stafford M, Moran DS, Pyne SW, Roberts WO. American College of Sports Medicine position stand: exertional heat illness during training and competition. Med Sci Sports Exerc 2007; 39: 556-72.
65. Schermann H, Craig E, Yanovich E, Ketko I, Kalmanovich G, Yanovich R. Probability of heat intolerance: standardized interpretation of heat-tolerance testing results versus specialist judgment. J Athl Train 2018; 53: 423-30.
66. Roiz de Sa D, House C. Exercise heat tolerance assessment following a diagnosis of heat illness in UK military personnel. Extrem Physiol Med 2015; 4: Suppl 1: A105.
67. Roberts WO, Dorman JC, Bergeron MF. Recurrent heat stroke in a runner: race simulation testing for return to activity. Med Sci Sports Exerc 2016; 48: 785-9.
68. Sonna LA, Wenger CB, Flinn S, Sheldon HK, Sawka MN, Lilly CM. Exertional heat injury and gene expression changes: a DNA microarray analysis study. J Appl Physiol (1985) 2004; 96: 1943-53.
69. Zhang HJ, Drake VJ, Morrison JP, Oberley LW, Kregel KC. Selected contribution: differential expression of stress-related genes with aging and hyperthermia. J Appl Physiol (1985) 2002; 92: 1762-9.
70. Horowitz M, Kopeliovitch D, Berdugo R, et al. Revisiting heat tolerance: gene expression profiling response. In: Proceedings of the 7th International Conference on the Physiology and Pharmacology of Temperature Regulation, Split, Croatia, October 7–12, 2018: 58.
71. Schwimmer H, Eli-Berchoer L, Horowitz M. Acclimatory-phase specificity of gene expression during the course of heat acclimation and superimposed hypohydration in the rat hypothalamus. J Appl Physiol (1985) 2006; 100: 1992-2003.
72. Poussel M, Guerci P, Kaminsky P, et al. Exertional heat stroke and susceptibility to malignant hyperthermia in an athlete: evidence for a link? J Athl Train 2015; 50: 1212-4.
73. Protasi F, Paolini C, Dainese M. Calsequestrin-1: a new candidate gene for malignant hyperthermia and exertional/environmental heat stroke. J Physiol 2009; 587: 3095-100.
74. Sagui E, Montigon C, Abriat A, et al. Is there a link between exertional heat stroke and susceptibility to malignant hyperthermia? PLoS One 2015; 10(8): e0135496.
75. Harmon KG, Drezner JA, Klossner D, Asif IM. Sickle cell trait associated with a RR of death of 37 times in National Collegiate Athletic Association football athletes: a database with 2 million athlete years as the denominator. Br J Sports Med 2012; 46: 325-30.
76. Nelson DA, Deuster PA, O’Connor FG, Kurina LM. Sickle cell trait and heat injury among US Army soldiers. Am J Epidemiol 2018; 187: 523-8.
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