Una guía actualizada para su diagnóstico y tratamiento | 07 JUN 20

Pancreatitis aguda grave

La evidencia sugiere que el tratamiento inicial enfocado hacia objetivos, el apoyo nutricional y la vigilancia de las posibles complicaciones son lo más adecuado.
Autor/a: Hines OJ, Pandol SJ BMJ 2019;367: l6227
INDICE:  1. Texto principal | 2. Referencias bibliográficas
Referencias bibliográficas

1 Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 2013;144:1252-61.

2 Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology 2012;143:1179-1187.e3.

3 Setiawan VW, Monroe K, Lugea A, Yadav D, Pandol S. Uniting Epidemiology and Experimental Disease Models for Alcohol-Related Pancreatic Disease. Alcohol Res 2017;38:173-82.

4 Shafqet M, Sharzehi K. Diabetes and the Pancreatobiliary Diseases. Curr Treat Options Gastroenterol 2017;15:508-19.

5 Lai SW, Muo CH, Liao KF, Sung FC, Chen PC. Risk of acute pancreatitis in type 2 diabetes and risk reduction on antidiabetic drugs: a population-based cohort study in Taiwan. Am J Gastroenterol 2011;106:1697-704.

6 Gonzalez-Perez A, Schlienger RG, Rodríguez LA. Acute pancreatitis in association with type 2 diabetes and antidiabetic drugs: a population-based cohort study. Diabetes Care 2010;33:2580-5.

7 Uc A, Andersen DK, Bellin MD, et al. Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas 2016;45:1365-75.

8 Kumar S, Ooi CY, Werlin S, et al. Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis: Lessons From INSPPIRE. JAMA Pediatr 2016;170:562-9. doi:10.1001/jamapediatrics.2015.4955

9 Setiawan VW, Pandol SJ, Porcel J, et al. Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. Pancreas 2016;45:819-25.

10 Lugea A, Gerloff A, Su HY, et al. The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. Gastroenterology 2017;153:1674-86. doi:10.1053/j.gastro.2017.08.036

11 Setiawan VW, Pandol SJ, Porcel J, et al. Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. Pancreas 2016;45:819-25.

12 Lugea A, Gerloff A, Su HY, et al. The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. Gastroenterology 2017;153:1674-86. doi:10.1053/j.gastro.2017.08.036

13 Lugea A, Tischler D, Nguyen J, et al. Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage. Gastroenterology 2011;140:987-97. doi:10.1053/j.gastro.2010.11.038

14 Setiawan VW, Pandol SJ, Porcel J, et al. Dietary Factors Reduce Risk ofAcute Pancreatitis in a Large Multiethnic Cohort. Clin Gastroenterol Hepatol 2017;15:257-265.e3. doi:10.1016/j.cgh.2016.08.038

15 Wu BU, Pandol SJ, Liu IL. Simvastatin is associated with reduced risk of acute pancreatitis: findings from a regional integrated healthcare system. Gut 2015;64:133-8. doi:10.1136/gutjnl-2013-306564

16 Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med 2016;375:1972-81. doi:10.1056/NEJMra1505202

17 Coté GA, Yadav D, Slivka A, et al, North American Pancreatitis Study Group. Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis. Clin Gastroenterol Hepatol 2011;9:266-73, quiz e27.

18 Samokhvalov AV, Rehm J, Roerecke M. Alcohol Consumption as a Risk Factor for Acute and Chronic Pancreatitis: A Systematic Review and a Series of Meta-analyses. EBioMedicine 2015;2:1996-2002.

19 Yadav D, Hawes RH, Brand RE, et al, North American Pancreatic Study Group. Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med 2009;169:1035-45.

20 Gukovskaya AS, Gorelick FS, Groblewski GE, et al. Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. Pancreas 2019;48:459-70.

21 Valdivielso P, Ramírez-Bueno A, Ewald N. Current knowledge of hypertriglyceridemic pancreatitis. Eur J Intern Med 2014;25:689-94.

22 Adiamah A, Psaltis E, Crook M, Lobo DN. A systematic review of the epidemiology, pathophysiology and current management of hyperlipidaemic pancreatitis. Clin Nutr 2018;37(6 Pt A):1810-22.

23 Sue LY, Batech M, Yadav D, et al. Effect of Serum Triglycerides on Clinical Outcomes in Acute Pancreatitis: Findings From a Regional Integrated Health Care System. Pancreas 2017;46:874-9.

24 Nawaz H, Koutroumpakis E, Easler J, et al. Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis. Am J Gastroenterol 2015;110:1497-503. doi:10.1038/ajg.2015.261

25 Forsmark ChE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med 2017;376:598-9.

26 Forsmark CE. Incretins, Diabetes, Pancreatitis and Pancreatic Cancer: What the GI specialist needs to know. Pancreatology 2016;16:10-3.

27 Monami M, Nreu B, Scatena A, et al. Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials. Diabetes Obes Metab 2017;19:1233-41.

28 Storgaard H, Cold F, Gluud LL, Vilsbøll T, Knop FK. Glucagon-like peptide-1 receptor agonists and risk of acute pancreatitis in patients with type 2 diabetes. Diabetes Obes Metab 2017;19:906-8.

29 Azoulay L, Filion KB, Platt RW, et al, and the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Association Between Incretin-Based Drugs and the Risk of Acute Pancreatitis. JAMA Intern Med 2016;176:1464-73.

30 Whitcomb DC. Genetic risk factors for pancreatic disorders. Gastroenterology 2013;144:1292-302.

31 Whitcomb DC, LaRusch J, Krasinskas AM, et al, Alzheimer’s Disease Genetics Consortium. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet 2012;44:1349-54.

32 Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol 2019;16:175-84.

33 Banks PA, Bollen TL, Dervenis C, et al, Acute Pancreatitis Classification

Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013;62:102-11.

34 Vege SS, DiMagno MJ, Forsmark CE, Martel M, Barkun AN. Initial Medical Treatment of Acute Pancreatitis: American Gastroenterological Association Institute Technical Review. Gastroenterology 2018;154:1103-39.

35 Crockett S, Falck-Ytter Y, Wani S, Gardner TB. Acute Pancreatitis Guideline. Gastroenterology 2018;154:1102.

36 Mounzer R, Langmead CJ, Wu BU, et al. Comparison of existing clinical scoring systems to predict persistent organ failure in patientswith acute pancreatitis. Gastroenterology 2012;142:1476-82,

37 Wu BU, Batech M, Quezada M, et al. Dynamic Measurement of Disease Activity in Acute Pancreatitis: The Pancreatitis Activity Scoring System. Am J Gastroenterol 2017;112:1144-52.

38 Buxbaum J, Quezada M, Chong B, et al. The Pancreatitis Activity Scoring System predicts clinical outcomes in acute pancreatitis: findings from a prospective cohort study. Am J Gastroenterol 2018;113:755-64.

39 Wu BU, Hwang JQ, Gardner TH, et al. Lactated Ringer’s solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol 2011;9:710-717.

40 Choosakul S, Harinwan K, Chirapongsathorn S, Puttapitakpong C. Comparison of normal saline versuslactated Ringer’s solution for fluid resuscitation in patients with acute pancreatitis, a randomized controlled trial. Gastroenterology 2017;152(Suppl 1):S72.

41 Du XJ, Hu WM, Xia Q, et al. Hydroxyethyl starch resuscitation reduces the risk of intra-abdominal hypertension in severe acute pancreatitis. Pancreas 2011;40:1220-5.

42 Perner A, Haase N, Guttormsen AB, et al, 6S Trial Group, Scandinavian Critical Care Trials Group. Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med 2012;367:124-34.

43 Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology 2013;13(Suppl 2):e1-15.

44 Wang MD, Ji Y, Xu J, Jiang DH, Luo L, Huang SW. Early goaldirected fluid therapy with fresh frozen plasma reduces severe acute pancreatitis mortality in the intensive care unit. Chin Med J (Engl) 2013;126:1987-8.

45 Crockett SD, Wani S, Gardner TB, Falck-Ytter Y, Barkun AN, American Gastroenterological Association Institute Clinical Guidelines Committee. American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis. Gastroenterology 2018;154:1096-101.

46 Muthusamy VR, Chandrasekhara V, Acosta RD, et al, ASGE Standards of Practice Committee. The role of endoscopy in the diagnosis and treatment of inflammatory pancreatic fluid collections. Gastrointest Endosc 2016;83:481-8.

47 Mazaki T, Ishii Y, Takayama T. Meta-analysis of prophylactic antibiotic use in acute necrotizing pancreatitis. Br J Surg 2006;93:674-84.

48 de Vries AC, Besselink MG, Buskens E, et al. Randomized controlled trials of antibiotic prophylaxis in severe acute pancreatitis: relationship between methodological quality and outcome. Pancreatology 2007;7:531-8.

49 Villatoro E, Mulla M, Larvin M. Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. Cochrane Database Syst Rev 2010;(5):CD002941.

50 Luiten EJ, Hop WC, Lange JF, Bruining HA. Controlled clinical trial of selective decontamination for the treatment of severe acute pancreatitis. Ann Surg 1995;222:57-65.

51 Besselink MG, van Santvoort HC, Buskens E, et al, Dutch Acute Pancreatitis Study Group. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebocontrolled trial. Lancet 2008;371:651-9.

52 Petrov MS, van Santvoort HC, Besselink MG, van der Heijden GJ, Windsor JA, Gooszen HG, Dutch Acute Pancreatitis Study Group. Enteral nutrition and the risk of mortality and infectious complications in patients with severe acute pancreatitis: a metaanalysis of randomized trials. Arch Surg 2008;143:1111-7.

53 Al-Omran M, Albalawi ZH, Tashkandi MF, Al-Ansary LA. Enteral versus parenteral nutrition for acute pancreatitis. Cochrane Database Syst Rev 2010;(1):CD002837.

54 Petrov MS, Loveday BP, Pylypchuk RD, McIlroy K, Phillips AR, Windsor JA. Systematic review and meta-analysis of enteral nutrition formulations in acute pancreatitis. Br J Surg 2009;96:1243-52.

55 Bakker OJ, van Brunschot S, van Santvoort HC, et al, Dutch Pancreatitis Study Group. Early versus on-demand nasoenteric tube feeding in acute pancreatitis. N Engl J Med 2014;371:1983-93.

56 Kumar A, Singh N, Prakash S, Saraya A, Joshi YK. Early enteral nutrition in severe acute pancreatitis: a prospective randomized controlled trial comparing nasojejunal and nasogastric routes. J Clin Gastroenterol 2006;40:431-4.

57 Ronellenfitsch U. How does somatostatin (or its analogue octreotide) compare with placebo/no intervention for adults with acute pancreatitis? 2017. https://www.cochranelibrary.com/cca/

58 Siriwardena AK, Mason JM, Balachandra S, et al. Randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis. Gut 2007;56:1439-44.

59 Vege SS, Atwal T, Bi Y, Chari ST, Clemens MA, Enders FT. Pentoxifylline Treatment in Severe Acute Pancreatitis: A Pilot, Double-Blind, Placebo-Controlled, Randomized Trial. Gastroenterology 2015;149:318-20.

60 Johnson CD, Kingsnorth AN, Imrie CW, et al. Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. Gut 2001;48:62-9.

61 Büchler M, Malfertheiner P, Uhl W, et al, German Pancreatitis Study Group. Gabexate mesilate in human acute pancreatitis. Gastroenterology 1993;104:1165-70.

62 Moggia E, Koti R, Belgaumkar AP, et al. Pharmacological interventions for acute pancreatitis. Cochrane Database Syst Rev 2017;4:CD011384.

63 Teerenhovi O, Nordback I, Eskola J. High volume lesser sac lavage in acute necrotizing pancreatitis. Br J Surg 1989;76:370-3.

64 Ihse I, Evander A, Gustafson I, Holmberg JT. Influence of peritoneal lavage on objective prognostic signs in acute pancreatitis. Ann Surg 1986;204:122-7.

65 Mayer AD, McMahon MJ, Corfield AP, et al. Controlled clinical trial of peritoneal lavage for the treatment of severe acute pancreatitis. N Engl J Med 1985;312:399-404.

66 Ranson JH, Berman RS. Long peritoneal lavage decreases pancreatic sepsis in acute pancreatitis. Ann Surg 1990;211:708-16, discussion 716-8.

67 Dong Z, Petrov MS, Xu J, Shanbhag S, Windsor JA, Pang S. Peritoneal lavage for severe acute pancreatitis: a systematic review of randomised trials. World J Surg 2010;34:2103-8.

68 Neoptolemos JP, Carr-Locke DL, London NJ, Bailey IA, James D, Fossard DP. Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones. Lancet 1988;2:979-83. doi:10.1016/S0140-6736(88)90740-4

69 Nowak A, Nowakowska-Dulawa E, Marek TA, Rybicka J. Final results of the prospective, randomized, controlled study on endoscopic sphincterotomy versus conventional management in acute biliary pancreatitis. Gastroenterology 1995;108:A380.

70 Fan ST, Lai EC, Mok FP, Lo CM, Zheng SS, Wong J. Early treatment of acute biliary pancreatitis by endoscopic papillotomy. N Engl J Med 1993;328:228-32.

71 Fölsch UR, Nitsche R, Lüdtke R, Hilgers RA, Creutzfeldt W, The German Study Group on Acute Biliary Pancreatitis. Early ERCP and papillotomy compared with conservative treatment for acute biliary pancreatitis. N Engl J Med 1997;336:237-42.

72 van Santvoort HC, Besselink MG, de Vries AC, et al, Dutch Acute Pancreatitis Study Group. Early endoscopic retrograde cholangiopancreatography in predicted severe acute biliary pancreatitis: a prospective multicenter study. Ann Surg 2009;250:68-75. doi:10.1097/SLA.0b013e3181a77bb4

73 Morton JM, Brown A, Galanko JA, Norton JA, Grimm IS, Behrns KE. A national comparison of surgical versus percutaneous drainage of pancreatic pseudocysts: 1997-2001. J Gastrointest Surg 2005;9:15-20, discussion 20-1.

74 Varadarajulu S, Bang JY, Sutton BS, Trevino JM, Christein JD, Wilcox CM. Equal efficacy of endoscopic and surgical cystogastrostomy for pancreatic pseudocyst drainage in a randomized trial. Gastroenterology 2013;145:583-90.e1.

75 Rau B, Pralle U, Uhl W, Schoenberg MH, Beger HG. Management of sterile necrosis in instances of severe acute pancreatitis. J Am Coll Surg 1995;181:279-88.

76 van Brunschot S, Fockens P, Bakker OJ, et al. Endoscopic transluminal necrosectomy in necrotising pancreatitis: a systematic review. Surg Endosc 2014;28:1425-38. doi:10.1007/s00464-013-3382-9

77 van Baal MC, van Santvoort HC, Bollen TL, Bakker OJ, Besselink MG, Gooszen HG, Dutch Pancreatitis Study Group. Systematic review of percutaneous catheter drainage as primary treatment for necrotizing pancreatitis. Br J Surg 2011;98:18-27.

78 van Santvoort HC, Besselink MG, Bakker OJ, et al, Dutch Pancreatitis Study Group. A step-up approach or open necrosectomy for necrotizing pancreatitis. N Engl J Med 2010;362:1491-502.

79 Bakker OJ, van Santvoort HC, van Brunschot S, et al, Dutch Pancreatitis Study Group. Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis: a randomized trial. JAMA 2012;307:1053-61.

80 van Brunschot S, van Grinsven J, van Santvoort HC, et al, Dutch Pancreatitis Study Group. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet 2018;391:51-8.

81 Balachandra S, Siriwardena AK. Systematic appraisal of the management of the major vascular complications of pancreatitis. Am J Surg 2005;190:489-95.

82 Vivian E, Cler L, Conwell D, et al. Acute Pancreatitis Task Force on Quality: Development of Quality Indicators for Acute Pancreatitis Management. Am J Gastroenterol 2019;114:1322-42.



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