Revisión sistemática | 20 NOV 17

Edulcorantes no nutritivos y salud cardiometabólica

A pesar del gran consumo de edulcorantes no nutritivos, como el aspartame, la sucralosa y los esteviósidos, su impacto a largo plazo sobre la salud es incierto
Autor/a: Azad MB, Abou-Setta AM, Chauhan BF
INDICE:  1. Página 1 | 2.  Referencias bibliográficas
Referencias bibliográficas

1. Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384:766-81.

2. Johnson RK, Appel LJ, Brands M, et al. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation 2009; 120:1011-20.

3. Siervo M, Montagnese C, Mathers JC, et al. Sugar consumption and global prevalence of obesity and hypertension: an ecological analysis. Public Health Nutr 2014; 17:587-96.

4. Gardner C, Wylie-Rosett J, Gidding SS, et al. Nonnutritive sweeteners: current use and health perspectives: a scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care 2012; 35:1798-808.

5. Sylvetsky AC, Welsh JA, Brown RJ, et al. Low-calorie sweetener consumption is increasing in the United States. Am J Clin Nutr 2012; 96:640-6.

6. Sylvetsky AC, Rother KI. Trends in the consumption of low-calorie sweeteners. Physiol Behav 2016; 164(Pt B):446-50.

7. Swithers SE. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol Metab 2013; 24:431-41.

8. Nettleton JE, Reimer RA, Shearer J. Reshaping the gut microbiota: Impact of low calorie sweeteners and the link to insulin resistance? Physiol Behav 2016;164 (Pt B):488-93.

9. Fowler SP. Low-calorie sweetener use and energy balance: results from experimental studies in animals, and large-scale prospective studies in humans. Physiol Behav 2016;164(Pt B): 517-23.

10. Fitch C, Keim KS. Position of the academy of nutrition and dietetics: use of nutritive and nonnutritive sweeteners. J Acad Nutr Diet 2012; 112:739-58.

11. Pereira MA. Diet beverages and the risk of obesity, diabetes, and cardiovascular disease: a review of the evidence. Nutr Rev 2013; 71:433-40.

12. Miller PE, Perez V. Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies. Am J Clin Nutr 2014; 100:765-77.

13. Pan A, Hu FB. Question about a recent meta-analysis of low-calorie sweeteners and body weight. Am J Clin Nutr 2014; 100:1604.

14. Field AE, Sonneville KR, Falbe J, et al. Association of sports drinks with weight gain among adolescents and young adults. Obesity (Silver Spring) 2014; 22:2238-43.

15. Gearon E, Peeters A, Hodge A, et al. The role of dietary and physical activity behaviours in educational differences in weight gain among Australian adults — the Melbourne Collaborative Cohort Study. Obesity Res Clin Practice 2014;  8(S1):35-36.

16. Sakurai M, Nakamura K, Miura K, et al. Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle aged Japanese men. Eur J Nutr 2014; 53:251-8.

17. Vyas A, Rubenstein L, Robinson J, et al. Diet drink consumption and the risk of cardiovascular events: a report from the women’s health initiative. J Gen Intern Med 2015;30: 462-8.

18. Fowler SP, Williams K, Hazuda HP. Diet soda intake is associated with longterm increases in waist circumference in a biethnic cohort of older adults: the San Antonio Longitudinal Study of Aging. J Am Geriatr Soc 2015;63: 708-15.

19. Peters JC, Beck J, Cardel M, et al. The effects of water and non-nutritive sweetened beverages on weight loss and weight maintenance: a randomized clinical trial. Obesity (Silver Spring) 2016; 24:297-304.

20. Madjd A, Taylor MA, Delavari A, et al. Effects on weight loss in adults of replacing diet beverages with water during a hypoenergetic diet: a randomized, 24-wk clinical trial. Am J Clin Nutr 2015; 102:1305-12.

21. Smith JD, Hou T, Hu FB, et al. A comparison of different methods for evaluating diet, physical activity, and long-term weight gain in 3 prospective cohort studies. J Nutr 2015; 145:2527-34.

22. Lana A, Lopez-Garcia E, Rodriguez-Artalejo F. Consumption of soft drinks and health-related quality of life in the adult population. Eur J Clin Nutr 2015; 69: 1226-32.

23. Renault KM, Carlsen EM, Norgaard K, et al. Intake of sweets, snacks and soft drinks predicts weight gain in obese pregnant women: detailed analysis of the results of a randomised controlled trial. PLoS One 2015; 10:e0133041.

24. O’Connor L, Imamura F, Lentjes MAH, et al. Prospective associations and population impact of sweet beverage intake and type 2 diabetes, and effects of substitutions with alternative beverages. Diabetologia 2015; 58:1474-83.

25. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 2009; 62:e1-34.

26. Azad MB, Reid AE, Rabbani R, et al. Non-nutritive sweeteners and cardio-metabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. London (UK): National Institute for Health Research — PROSPERO International prospective register of systematic reviews; 2015. Available: asp?ID=CRD42015019749 (accessed 2016 Jan).

27. Reid AE, Chauhan B, Rabbani R, et al. Early exposure to non-nutritive sweeteners and long-term metabolic health: a systematic review. Pediatrics 2015; 137: 1-10.

28. Becker BJ, Wu M-J. The synthesis of regression slopes in meta-analysis. Statist Sci 2007; 22:414-29.

29. Higgins JPT, Green S, editors. Cochrane Handbook of Systematic Reviews of Interventions Version 5.1.0. [updated March 2011] edition. The Cochrane Collaboration;2011.

30. Julian PTH, Douglas GA, Peter GGT, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomized trials. BMJ 2011; 343:d5928.

31. Wells GA, Shea B, O’Connell D, et al. The Newcastle–Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analysis. Ottawa: The Ottawa Hospital Research Institute; 2013. Available:

32. Imamura F, O’Connor L, Ye Z, et al. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. BMJ 2015; 351:h3576.

33. Greenwood DC, Threapleton DE, Evans CE, et al. Association between  sugar sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and dose–response meta-analysis of prospective studies. Br J Nutr 2014;112: 725-34.

34. Tate DF, Turner-McGrievy G, Lyons E, et al. Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial. Am J Clin Nutr 2012; 95:555-63.

35. Maersk M, Belza A, Stodkilde-Jorgensen H, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr 2012; 95:283-9.



Para ver los comentarios de sus colegas o para expresar su opinión debe ingresar con su cuenta de IntraMed.

Términos y condiciones de uso | Política de privacidad | Todos los derechos reservados | Copyright 1997-2024