Los límites del reduccionismo | 20 FEB 18

Volviendo a armar a los pacientes: medicina social y medicina en red

En la práctica, la medicina personalizada aún tiende a reducir al paciente a una colección de secuencias moleculares precisas con un fenotipo detallado
Autor/a: Debra Malina, Ph.D., Editor, Jeremy A. Greene, M.D., Ph.D., and Joseph Loscalzo, M.D., Ph.D Fuente: Putting the Patient Back Together — Social Medicine, Network Medicine, and the Limits of Reductionism N Engl J Med 2017; 377:2493-2499December 21, 2017DOI: 10.1056/NEJMms1706744
INDICE:  1. Página 1 | 2. Referencias bibliográficas
Referencias bibliográficas

1. Jewson N. The disappearance of the ‘sick-man’ from medical cosmology, 1770–1870. Sociology  1970;10:225-44.
2. Stevens H. Networks: representations and tools in postgenomics. In: Richardson SS, Stevens H, eds. Postgenomics: perspectives on biology after the genome. Durham, NC: Duke University Press, 2015:104-25.
3. Network medicine. In: Loscalzo J, Barabasi A-L, Silverman EK, eds. Complex systems in human disease and therapeutics. Cambridge, MA: Harvard University Press, 2017:1-16.
4. Nagel E. The meaning of reduction in the natural sciences. In: Stauffer RC, ed. Science and civilization. Madison: University of Wisconsin Press, 1961:99-135.
5. Kauffman SA. Origins of order: self-organization and selection in evolution. New York: Oxford University Press, 1993.
6. Temkin O. The scientific approach to disease: specific entity and individual illness. In: Crombie AC, ed. Scientific change: historical studies in the intellectual, social and technical conditions for scientific discovery and technical invention from antiquity to the present. New York: Basic Books, 1963:629-47.
7. Sydenham T. The works of Thomas Sydenham (Latham RG, trans). London: The Sydenham Society, 1848:13.
8. Faber K. Nosography in modern internal medicine. New York: Paul Hoeber, 1923.
9. Debru C. From nineteenth century ideas on reduction in physiology to non-reductive explanations in twentieth-century biochemistry. In: Regenmortel MHV, Hull DL, eds. Promises and limits of reductionism in the biomedical sciences. Philadelphia: John Wiley, 2002:35-46.
10. Dubos R, Dubos J. The white plague. Boston: Little, Brown, 1952.
11. McKeown T. The role of medicine: dream, mirage, or nemesis? London: Nuffield Provincial Hospitals Trust,  1976.
12. Ilich I. Medical nemesis: the expropriation of health. London: Calder & Boyars, 1974.
13. Fox RC. Essays in medical sociology: journeys into the field. New York: John Wiley, 1979.
14. Kleinman A. Patients and healers in the context of culture: an exploration of the borderland between anthropology, medicine, and sociology. Berkeley: University of California Press, 1980.
15. Brandt AM. No magic bullet: a social history of venereal disease. New York: Oxford University Press, 1985.
16. Wailoo K. Dying in the city of the blues: sickle cell anemia and the politics of race and health. Chapel Hill: University of North Carolina Press, 2000.
17. Nelkin D, Lindee MS. The DNA mystique: the gene as cultural icon. Ann Arbor: University of Michigan Press, 2013.
18. Loscalzo J, Kohane I, Barabasi AL. Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol Syst Biol 2007;3:124.
19. Loscalzo J. Association studies in an era of too much information: clinical analysis of new biomarker and genetic data. Circulation 2007;116:1866-70.
20. Pammolli F, Magazzini L, Riccaboni M. The productivity crisis in pharmaceutical R&D. Nat Rev Drug Discov 2011;10:428-38.
21. Wang RS, Loscalzo J. Illuminating drug action by network integration of disease genes: a case study of myocardial infarction. Mol Biosyst 2016;12:1653-66.
22. Loscalzo J. Personalized cardiovascular medicine and drug  development: time for a new paradigm. Circulation 2012;125: 638-45.
23. Watts DJ. Six degrees: the science of a connected age. New York: W.W. Norton; 2003
24. West DB. Introduction to graph theory, 2nd ed. Upper Saddle River, NJ: Prentice-Hall, 2001.
25. Zanzoni A, Soler-López M, Aloy P. A network medicine approach to human disease. FEBS Lett 2009;583:1759-65.
26. Pawson T, Linding R. Network medicine. FEBS Lett 2008; 582:1266-70.
27. Schadt EE. Molecular networks as sensors and drivers of common human diseases. Nature 2009;461:218-23.
28. Menche J, Sharma A, Kitsak M, et al. Disease networks: uncovering disease-disease relationships through the incomplete interactome. Science 2015;347:1257601.
29. McDunn JE, Husain KD, Polpitiya AD, et al. Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram. PLoS One 2008; 3(2):e1564.
30. Ghiassian SD, Menche J, Chasman DI, et al. Endophenotype network models: common core of complex diseases. Sci Rep 2016;6:27414.
31. Xie L, Li J, Xie L, Bourne PE. Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors. PLoS Comput Biol 2009;5(5):e1000387.
32. Garmaroudi FS, Handy DE, Liu YY, Loscalzo J. Systems pharmacology and rational polypharmacy: nitric oxide-cyclic GMP signaling pathway as an illustrative example and derivation of the general case. PLoS Comput Biol 2016;12(3):e1004822.
33. Christakis NA, Fowler JH. The spread of obesity in a large social network over 32 years. N Engl J Med 2007;357:370-9.
34. Calver AD, Falmer AA, Murray M, et al. Emergence of increased resistance and extensively drug-resistant tuberculosis despite treatment adherence, South Africa. Emerg Infect Dis 2010;16:264-71.
35. Engel GL. The need for a new medical model: a challenge for biomedicine. Science 1977;196:129-36.

 

Comentarios

Para ver los comentarios de sus colegas o para expresar su opinión debe ingresar con su cuenta de IntraMed.

CONTENIDOS RELACIONADOS
AAIP RNBD
Términos y condiciones de uso | Todos los derechos reservados | Copyright 1997-2023