Microbiota intestinal y envejecimiento saludable

1 Sender R, Fuchs S, Milo R: Revised estimates for the number of human and bacteria cells in the body. PLoS Biol 2016; 14:e1002533.

2 Sommer F, Backhed F: The gut microbiota –masters of host development and physiology. Nat Rev Microbiol 2013; 11: 227–238.

3 Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, Mende DR, Li J, Xu J, Li S, Li D, Cao J, Wang B, Liang H, Zheng H, Xie Y, Tap J, Lepage P, Bertalan M, Batto JM, Hansen T, Le Paslier D, Linneberg A, Nielsen HB, Pelletier E, Renault P, Sicheritz-Ponten T, Turner K, Zhu H, Yu C, Li S, Jian M, Zhou Y, Li Y, Zhang X, Li S, Qin N, Yang H, Wang J, Brunak S, Dore J, Guarner F, Kristiansen K, Pedersen O, Parkhill J, Weissenbach J; MetaHIT Consortium, Bork P, Ehrlich SD, Wang J: A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464: 59–65.

4 Claesson MJ, Cusack S, O’Sullivan O, Greene-Diniz R, de Weerd H, Flannery E, Marchesi JR, Falush D, Dinan T, Fitzgerald G, Stanton C, van Sinderen D, O’Connor M, Harnedy N, O’Connor K, Henry C, O’Mahony D, Fitzgerald AP, Shanahan F, Twomey C, Hill C, Ross RP, O’Toole PW: Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A 2011; 108(suppl 1): 4586–4591.

5 Faith JJ, Guruge JL, Charbonneau M, Subramanian S, Seedorf H, Goodman AL, Clemente JC, Knight R, Heath AC, Leibel RL, Rosenbaum M, Gordon JI: The long-term stability of the human gut microbiota. Science 2013; 341: 1237439.

6 Schloissnig S, Arumugam M, Sunagawa S, Mitreva M, Tap J, Zhu A, Waller A, Mende DR, Kultima JR, Martin J, Kota K, Sunyaev SR, Weinstock GM, Bork P: Genomic variation landscape of the human gut microbiome. Nature 2013; 493: 45–50.

7 Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI: Human gut microbiome viewed across age and geography. Nature 2012; 486: 222–227.

8 Claesson MJ, Jeffery IB, Conde S, Power SE, O’Connor EM, Cusack S, Harris HM, Coakley M, Lakshminarayanan B, O’Sullivan O, Fitzgerald GF, Deane J, O’Connor M, Harnedy N, O’Connor K, O’Mahony D, van Sinderen D, Wallace M, Brennan L, Stanton C, Marchesi JR, Fitzgerald AP, Shanahan F, Hill C, Ross RP, O’Toole PW: Gut microbiota composition correlates with diet and health in the elderly. Nature 2012; 488: 178–184.

9 Westfall S, Lomis N, Kahouli I, Dia SY, Singh SP, Prakash S: Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis. Cell Mol Life Sci 2017; 74: 3769–3787.

10 Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R: Diversity, stability and resilience of the human gut microbiota. Nature 2012; 489: 220–230.

11 Lloyd-Price J, Abu-Ali G, Huttenhower C: The healthy human microbiome. Genome Med 2016; 8: 51.

12 Biagi E, Franceschi C, Rampelli S, Severgnini M, Ostan R, Turroni S, Consolandi C, Quercia S, Scurti M, Monti D, Capri M, Brigidi P, Candela M: Gut microbiota and extreme longevity. Curr Biol 2016; 26: 1480–1485.

13 Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Dore J; MetaHIT Consortium, Antolin M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, Merieux A, Melo Minardi R, M’Rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich SD, Bork P: Enterotypes of the human gut microbiome. Nature 2011; 473: 174–180.

14 Kim S, Jazwinski SM: Quantitative measures of healthy aging and biological age. Healthy Aging Res 2015; 4:pii: 26.

15 van Tongeren SP, Slaets JP, Harmsen HJ, Welling GW: Fecal microbiota composition and frailty. Appl Environ Microbiol 2005; 71: 6438–6442.

16 Jackson MA, Jeffery IB, Beaumont M, Bell JT, Clark AG, Ley RE, O’Toole PW, Spector TD, Steves CJ: Signatures of early frailty in the gut microbiota. Genome Med 2016; 8: 8.

17 Maffei VJ, Kim S, Blanchard E 4th, Luo M, Jazwinski SM, Taylor CM, Welsh DA: Biological Aging and the Human Gut Microbiota. J Gerontol A Biol Sci Med Sci 2017; 72: 1474– 1482.

18 Anderson OS, Sant KE, Dolinoy DC: Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J Nutr Biochem 2012; 23:853–859.

19 Alic N, Partridge L: Death and dessert: nutrient signalling pathways and ageing. Curr Opin Cell Biol 2011; 23: 738–743.

20 Alcedo J, Kenyon C: Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons. Neuron 2004; 41: 45–55.

21 Libert S, Chao Y, Chu X, Pletcher SD: Tradeoffs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling. Aging Cell 2006; 5: 533–543.

22 Martins R, Lithgow GJ, Link W: Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell 2016; 15: 196–207.

23 Kwon ES, Narasimhan SD, Yen K, Tissenbaum HA: A new DAF-16 isoform regulates longevity. Nature 2010; 466: 498–502.

24 Libina N, Berman JR, Kenyon C: Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 2003; 115: 489–502.

25 Clark RI, Salazar A, Yamada R, Fitz-Gibbon S, Morselli M, Alcaraz J, Rana A, Rera M, Pellegrini M, Ja WW, Walker DW: Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality. Cell reports 2015; 12: 1656–1667.

26 Bolukbasi E, Khericha M, Regan JC, Ivanov DK, Adcott J, Dyson MC, Nespital T, Thornton JM, Alic N, Partridge L: Intestinal fork head regulates nutrient absorption and promotes longevity. Cell reports 2017; 21: 641–653.

27 Saxton RA, Sabatini DM: mTOR signaling in growth, metabolism, and disease. Cell 2017; 168: 960–976.

28 Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padron A, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ: Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice. Aging Cell 2015; 14: 945–956.

29 Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, Gillespie CH, Snyder JM, Treuting PM, Kaeberlein M: Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Elife 2016; 5:pii:e16351.