¿Tienen valor predictivo? | 19 AGO 18

Virus respiratorios y falla en el tratamiento en niños asmáticos

Los pacientes con Influenza o Parainfluenza positivo tuvieron un 20 % más de falla en el tratamiento que los pacientes con virus negativos.
Autor/a: Joanna Merckx, Francine M. Ducharme, Christine Martineau, y colaboradores  Respiratory Viruses and Treatment Failure in Children With Asthma Exacerbation
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3. Cox DW, Bizzintino J, Ferrari G, et al. Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions. Am J Respir Crit Care Med. 2013;188(11):1358–1364

4. Bizzintino J, Lee WM, Laing IA, et al. Association between human rhinovirus C and severity of acute asthma in children. Eur Respir J. 2011;37(5):1037–1042

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6. Gill PJ, Ashdown HF, Wang K, et al. Identification of children at risk of influenza-related complications in primary and ambulatory care: a systematic review and meta-analysis. Lancet Respir Med. 2015;3(2):139–149 7. Duenas Meza E, Jaramillo CA, Correa E, et al. Virus and mycoplasma pneumoniae prevalence in a selected pediatric population with acute asthma exacerbation. J Asthma. 2016;53(3):253–260

8. National Institutes of Health. Guidelines for the diagnosis and management of asthma. 2007. Available at: https:// www.nhlbi.nih.gov/health-pro/ guidelines/current/asthma-guidelines/ full-report. Accessed April 25, 2018 9. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2017. Available at: http:// ginasthma.org/2018-gina-report-globalstrategy-for-asthma-management-andprevention/. Accessed April, 25, 2018

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11. Ducharme FM, Zemek R, Chauhan BF, et al; DOORWAY Research Group of the Pediatric Emergency Research in Canada Network. Factors associated with failure of emergency department management in children with acute moderate or severe asthma: a prospective, multicentre, cohort study. Lancet Respir Med. 2016;4(12):990–998

12. Ducharme FM, Dell SD, Radhakrishnan D, et al. Diagnosis and management of asthma in preschoolers: a Canadian Thoracic Society and Canadian Paediatric Society position paper. Can Respir J. 2015;22(3):135–143 13. Castro-Rodriguez JA. The Asthma Predictive Index: a very useful tool for predicting asthma in young children. J Allergy Clin Immunol. 2010;126(2):212–216

14. Ducharme FM, Chalut D, Plotnick L, et al. The pediatric respiratory assessment measure: a valid clinical score for assessing acute asthma severity from toddlers to teenagers. J Pediatr. 2008;152(4):476–480, 480.e1 15. Raymond F, Carbonneau J, Boucher N, et al. Comparison of automated microarray detection with real-time PCR assays for detection of respiratory viruses in specimens obtained from children. J Clin Microbiol. 2009;47(3):743–750

16. Seegene. Seeplex PneumoBacter ACE Detection. 2017. Available at: www. 10 MERCKX et al Dr Merckx conceptualized the data analysis, conducted the analysis and presentation of results, and wrote the manuscript; Dr Ducharme provided the primary study data, protocol, and statistical analysis from the primary study, provided feedback on the analysis protocol, interpretation of results, and feedback on manuscript revisions, and revised the final version; Dr Quach led the laboratory analysis of the respiratory specimens, supervised the data analysis plan, statistical analysis, and manuscript writing, provided feedback on the interpretation of results and manuscript revisions and funding for the substudy, and revised the final version; Drs Martineau, Zemek, Gravel, Chalut, and Poonai provided feedback on manuscript revisions and revised the final version; and all authors approved the final manuscript as submitted. This trial has been registered at www.clinicaltrials.gov (identifier NCT02013076). DOI: https://doi.org/10.1542/peds.2017-4105 Accepted for publication Apr 3, 2018 Address correspondence to Caroline Quach, MD, MSc, Infection Prevention and Control Unit, CHU Sainte-Justine, 3175 Cote Sainte-Catherine, Montreal, QC H3T 1C5, Canada. E-mail: c.quach@umontreal.ca PEDIATRICS (ISSN Numbers: Print, 0031-4005; Online, 1098-4275). Copyright © 2018 by the American Academy of Pediatrics FINANCIAL DISCLOSURE: Dr Quach was supported through an external salary award (Fonds de recherche du Québec – Santé (FRQ-S) senior, grant 26873); the other authors have indicated they have no financial relationships relevant to this article to disclose. FUNDING: Supported by the Canadian Institutes of Health Research (grant 102547) under the title “Determinants of Oral Corticosteroid Responsiveness in Wheezing Asthmatic Youth.” Additional testing was supported by internal funds. POTENTIAL CONFLICT OF INTEREST: Dr Ducharme received unrestricted donations from Boehringer Ingelheim, Merck Canada, GlaxoSmithKline, and Novartis and a research grant from Merck and is serving on an advisory board of Boehringer Ingelheim, Sanofi Regeneron, and AstraZeneca unrelated to the current study. Dr Quach has received funding from Sage Products LLC and AbbVie for research grants unrelated to the current study; the other authors have indicated they have no potential conflicts of interest to disclose. Downloaded from www.aappublications.org/news by guest on August 15, 2018 seegene.com/neo/en/products/ respiratory/seeplex_PneumoBacter. php. Accessed May 8, 2017

 

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