Deficiencia de zinc en niños

1 Huang L, Tepaamorndech S. The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles. Mol Aspects Med. 2013; 34:548–60.
2 Jeong J, Eide DJ. The SLC39 family of zinc transporters. Mol Aspects Med. 2013; 34:612–19.
3 Hambidge M. Underwood Memorial Lecture: Human zinc homeostasis: good but not perfect. J Nutr. 2003; 133:1438–42S.
4 Williams RB, Mills CF. The experimental production of zinc deficiency in the rat. Br J Nutr. 1970; 24:989–1003.
5 Golden MHN. The Diagnosis of Zinc Deficiency. In: Mills C, ed. Zinc in Human Biology. London: Springer-Verlag, 1989; pp 323–33.
6 Hambidge KM. Zinc deficiency in man: its origins and effects. Philos Trans R Soc Lond B Biol Sci. 1981; 294:129–44.
7 Prasad AS. Zinc in human health: effect of zinc on immune cells. Mol Med. 2008; 14:353–7.
8 Wapnir RA. Zinc deficiency, malnutrition and the gastrointestinal tract. J Nutr. 2000; 130:1388–92S.
9 Berni Canani R, Buccigrossi V, Passariello A. Mechanisms of action of zinc in acute diarrhea. Curr Opin Gastroenterol. 2011; 27:8–12.
10 Kulkarni H, Mamtani M, Patel A. Roles of zinc in the pathophysiology of acute diarrhea. Curr Infect Dis Rep. 2012; 14:24–32.
11 Song Y, Leonard SW, Traber MG, Ho E. Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. J Nutr. 2009; 139:1626–31.
12 Eide DJ. The oxidative stress of zinc deficiency. Metallomics. 2011; 3:1124–9.
13 King JC. Zinc: an essential but elusive nutrient. Am J Clin Nutr. 2011; 94:679–84S.
14 Castillo-Duran C, Vial P, Uauy R. Trace mineral balance during acute diarrhea in infants. J Pediatr. 1988; 113:452–7.
15 Manary MJ, Abrams SA, Griffin IJ, Quimper MM, Shulman RJ, Hamzo MG, et al. Perturbed zinc homeostasis in rural 3-5- y-old Malawian children is associated with abnormalities in intestinal permeability attributed to tropical enteropathy. Pediatr Res. 2010; 67:671–5.
16 Mohammad MK, Zhou Z, Cave M, Barve A, McClain CJ. Zinc and liver disease. Nutr Clin Pract. 2012; 27:8–20.
17 Uriu-Adams JY, Keen CL. Zinc and reproduction: effects of zinc deficiency on prenatal and early postnatal development. Birth Defects Res B Dev Reprod Toxicol. 2010; 89:313–25.
18 de Benoist B, Darnton-Hill I, Davidsson L, Fontaine O, Hotz C. Conclusions of the Joint WHO/UNICEF/IAEA/IZiNCG Interagency Meeting on Zinc Status Indicators. Food Nutr Bull. 2007; 28:S480–4.
19 Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington, DC: National Academy Press, 2001.
20 Institute of Medicine. DietaryReference Intakes: Applications in Dietary Assessment. Washington, DC: National Academy Press, 2000.
21 Hotz C, Peerson JM, Brown KH. Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the second National Health and Nutrition Examination Survey
data (1976–1980). Am J Clin Nutr. 2003; 78:756–64.
22 Brown KH, Rivera JA, Bhutta Z, Gibson RS, King JC, Lonnerdal B, et al. International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull. 2004; 25:S99–203.
23 Gibson RS. A historical review of progress in the assessment of dietary zinc intake as an indicator of population zinc status. Adv Nutr. 2012; 3:772–82.
24 Wessells KR, Brown KH. Estimating the global prevalence of zinc deficiency: results based on zinc availability in national food supplies and the prevalence of stunting. PLoS One. 2012; 7:e50568.
25 Engle-Stone R, Ndjebayi AO, Nankap M, Killilea DW, Brown KH. Stunting prevalence, plasma zinc concentrations, and dietary zinc intakes in a nationally representative sample suggest a high risk of zinc deficiency among women and young children in Cameroon. J Nutr. 2014; 144:382–91.
26 Hambidge M. Human zinc deficiency. J Nutr. 2000; 130:1344S–9S.
27 Bhutta ZA, Black RE, Brown KH, Gardner JM, Gore S, Hidayat A, et al. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. J Pediatr. 1999; 135:689–97.
28 Brown KH, Peerson JM, Rivera J, Allen LH. Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2002; 75:1062–71.
29 Brown KH, Peerson JM, Baker SK, Hess SY. Preventive zinc supplementation among infants, preschoolers, and older prepubertal children. Food Nutr Bull. 2009; 30:S12–40.
30 Krebs NF. Update on zinc deficiency and excess in clinical pediatric practice. Ann Nutr Metab. 2013; 62 suppl 1:19–29.
31 Hambidge KM, Krebs NF. Interrelationships of key variables of human zinc homeostasis: Relevance to dietary zinc requirements. Ann Rev Nutr. 2001;21:429–52.
32 Miller LV, Krebs NF, Hambidge KM. A mathematical model of zinc absorption in humans as a function of dietary zinc and phytate. J Nutr. 2007; 137:135–41.
33 Hambidge KM, Miller LV, Westcott JE, Sheng X, Krebs NF. Zinc bioavailability and homeostasis. Am J Clin Nutr. 2010; 91:1478–83S.
34 Krebs NE, Hambidge KM. Zinc metabolism and homeostasis: the application of tracer techniques to human zinc physiology. Biometals. 2001; 14:397–412.
35 Chung CS, Stookey J, Dare D, Welch R, Nguyen TQ, Roehl R, et al. Current dietary zinc intake has a greater effect on fractional zinc absorption than does longer term zinc consumption in healthy adult men. Am J Clin Nutr. 2008; 87:1224–9.
36 Krebs NF, Westcott J. Zinc and breastfed infants: if and when is there a risk of deficiency? Adv Exp Med Biol. 2002; 503:69–75.
37 Krebs NF, Hambidge KM, Westcott JE, Miller LV, Sian L, Bell M, et al. Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis. J Nutr. 2003; 133:1498–1501S.
38 Sian L, Mingyan X, Miller LV, Tong L, Krebs NF, Hambidge KM. Zinc absorption and intestinal losses of endogenous zinc in young Chinese women with marginal zinc intakes. Am J Clin Nutr. 1996; 63:348–53.
39 Crofton RW, Aggett PJ, Gvozdanovic S, Gvozdanovic D, Mowat NA, Brunt PW. Zinc metabolism in celiac disease. Am J Clin Nutr. 1990; 52:379–82.
40 Krebs NF, Westcott JE, Arnold TD, Kluger BM, Accurso FJ, Miller LV, et al. Abnormalities in zinc homeostasis in young infants with cystic fibrosis. Pediatr Res. 2000; 48:256–61.
41 Krebs NF, Reidinger CJ, Miller LV, Hambidge KM. Zinc homeostasis in breast-fed infants. Pediatr Res. 1996, 39:661–5.
42 Krebs NF. Zinc transfer to the breastfed infant. J Mammary Gland Biol Neoplasia. 1999, 4:259–68.
43 Krebs NF, Reidinger CJ, Hartley S, Robertson AD, Hambidge KM. Zinc supplementation during lactation: effects on maternal status and milk zinc concentrations. Am J Clin Nutr. 1995’61:1030–6.
44 Brown KH, Engle-Stone R, Krebs NF, Peerson JM. Dietary intervention strategies to enhance zinc nutrition: promotion and support of breastfeeding for infants and young children. Food Nutr Bull. 2009; 30:S144–71. Krebs et al. Zinc deficiency in infants and children Paediatrics and International Child Heal
45 Krebs NF, Hambidge KM. Zinc requirements and zinc intakes of breast-fed infants. Am J Clin Nutr. 1986; 43:288–92.
46 Krebs NF, Hambidge KM. Complementary feeding: clinically relevant factors affecting timing and composition. Am J Clin Nutr. 2007; 85:639–45S.
47 Sazawal S, Black RE, Dhingra P, Jalla S, Krebs NF, Malik P, et al. Zinc supplementation does not affect the breast milk zinc concentration of lactating women belonging to low socioeconomic population. J Hum Nutr Food Sci. 2013; 1:1014.
48 Samuel TM, Thomas T, Thankachan P, Bhat S, Virtanen SM, Kurpad AV. Breast milk zinc transfer and early post-natal growth among urban South Indian term infants using measures of breast milk volume and breast milk zinc concentrations. Maternal Child Nutr. 2014; 10:398–409.
49 Allen LH. B vitamins in breast milk: relative importance of maternal status and intake, and effects on infant status and function. Adv Nutr. 2012; 3:362–9.
50 Krebs NF, Abebe Y, Stoecker BJ, Gibson RS, Westcott JE, Hambidge KM. Intake of zinc from human milk and complementary foods by 7 month old infants from the Sidama Zone in Southern Ethiopia. FASEB J. 2006; 20:A985.
51 Krebs NF, Reidinger CJ, Robertson AD, Hambidge KM. Growth and intakes of energy and zinc in infants fed human milk. J Pediatr. 1994; 124:32–9.
52 Abebe Y, Bogale A, Hambidge KM, Stoecker BJ, Arbide I, Teshome A, et al. Inadequate intakes of dietary zinc among pregnant women from subsistence households in Sidama, Southern Ethiopia. Public Health Nutr. 2008; 11:379–86.
53 Stoecker BJ, Abebe Y, Hubbs-Tait L, Kennedy TS, Gibson RS, Arbide I, et al. Zinc status and cognitive function of pregnant women in Southern Ethiopia. Eur J Clin Nutr. 2009; 63:916–18.
54 Krebs NF, Westcott JE, Culbertson DL, Sian L, Miller LV, Hambidge KM. Comparison of complementary feeding strategies to meet zinc requirements of older breastfed infants. Am J Clin Nutr. 2012; 96:30–5.
55 Gibson RS, Abebe Y, Hambidge KM, Arbide I, Teshome A, Stoecker BJ. Inadequate feeding practices and impaired growth among children from subsistence farming households in Sidama, Southern Ethiopia. Matern Child Nutr. 2009; 5:260–75.
56 Umeta M, West CE, Haidar J, Deurenberg P, Hautvast JG. Zinc supplementation and stunted infants in Ethiopia: a randomised controlled trial. Lancet. 2000; 355:2021–6.
57 Arsenault JE, Yakes EA, IslamMM, HossainMB, Ahmed T,Hotz C, et al. Very low adequacy of micronutrient intakes by young children and women in rural Bangladesh is primarily explained by low food intake and limited diversity. J Nutr. 2013; 143:197–203.
58 Hambidge KM, Huffer JW, Raboy V, Grunwald GK, Westcott JL, Sian L, et al. Zinc absorption from low-phytate hybrids of maize and their wild-type isohybrids. Am J Clin Nutr. 2004; 79:1053–9.
59 Gibson RS, Ferguson EL, Lehrfeld J. Complementary foods for infant feeding in developing countries: their nutrient adequacy and improvement. Eur J Clin Nutr. 1998; 52:764–70.
60 Gibson RS, Smit Vanderkooy PD, Thompson L. Dietary phytate x calcium/zinc millimolar ratios and zinc nutriture in some Ontario preschool children. Biol Trace Elem Res. 1991; 30:87–94.
61 Cavan KR, Gibson RS, Grazioso CF, Isalgue AM, Ruz M, Solomons NW. Growth and body composition of periurban Guatemalan children in relation to zinc status: a cross-sectional study. Am J Clin Nutr. 1993; 57:334–43.
62 Jou MY, Philipps AF, Kelleher SL, Lonnerdal B. Effects of zinc exposure on zinc transporter expression in human intestinal cells of varying maturity. J Pediatr Gastroenterol Nutr. 2010; 50:587–95.
63 Jalla S, Krebs NF, Rodden D, Hambidge KM. Zinc homeostasis in premature infants does not differ between those fed preterm formula or fortified human milk. Pediatr Res. 2004; 56:615–20.
64 Hambidge KM, Krebs NF, Westcott JE, Miller LV. Changes in zinc absorption during development. J Pediatr. 2006; 149:S64–8.
65 Zlotkin SH, Cherian MG. Hepatic metallothionein as a source of zinc and cysteine during the first year of life. Pediatr Res. 1988; 24:326–9.
66 Krebs NF, Westcott JL, Rodden DJ, Ferguson KW, Miller LV, Hambidge KM. Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestationalage preterm infants. Am J Clin Nutr. 2006; 84:1340–3.
67 Osendarp SJ, van Raaij JM, Darmstadt GL, Baqui AH, Hautvast JG, Fuchs GJ. Zinc supplementation during pregnancy and effects on growth and morbidity in low birthweight infants: a randomised placebo controlled trial. Lancet. 2001; 357:1080-–5.
68 Sazawal S, Black RE, Menon VP, Dinghra P, Caulfield LE, Dhingra U, et al. Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial. Pediatrics. 2001; 108:1280–6.
69 Sur D, Gupta DN, Mondal SK, Ghosh S, Manna B, Rajendran K, Bhattacharya SK. Impact of zinc supplementation on diarrheal morbidity and growth pattern of low birth weight infants in kolkata, India: a randomized, double-blind, placebocontrolled, community-based study. Pediatrics. 2003; 112:1327–32.
70 Castillo-Duran C, Rodriguez A, Venegas G, Alvarez P, Icaza G. Zinc supplementation and growth of infants born small for gestational age. J Pediatr. 1995; 127:206–11.
71 Friel JK, Andrews WL, Matthew JD, Long DR, Cornel AM, Cox M, et al. Zinc supplementation in very-low-birth-weight infants. J Pediatr Gastroenterol Nutr. 1993; 17:97–104.
72 Patel AB, Mamtani M, Badhoniya N, Kulkarni H. What zinc supplementation does and does not achieve in diarrhea prevention: a systematic review and meta-analysis. BMC Infect Dis. 2011; 11:122.
73 Penny ME. Zinc supplementation in public health. Ann Nutr Metab. 2013; 62 (suppl):1:31–42.
74 Tran CD, Katsikeros R, Manton N, Krebs NF, Hambidge KM, Butler RN, et al. Zinc homeostasis and gut function in children with celiac disease. Am J Clin Nutr. 2011; 94:1026–32.
75 Guerrant RL, DeBoer MD, Moore SR, Scharf RJ, Lima AA. The impoverished gut–a triple burden of diarrhoea, stunting and chronic disease. Nat Rev Gastroenterol Hepatol. 2013; 10:220–9.
76 Prendergast A, Kelly P. Enteropathies in the developing world: neglected effects on global health. Am J Trop Med Hyg. 2012; 86:756–63.
77 Lindenmayer GW, Stoltzfus RJ, Prendergast AJ. Interactions between zinc deficiency and environmental enteropathy in developing countries. Adv Nutr. 2014; 5:1–6.
78 Louis-Auguste J, Greenwald S, Simuyandi M, Soko R, Banda R, Kelly P. High dose multiple micronutrient supplementation improves villous morphology in environmental enteropathy without HIV enteropathy: results from a double-blind randomised placebo controlled trial in Zambian adults. BMC Gastroenterol. 2014; 14:15.
79 Krebs NF, Hambidge KM, Ikemeri JE, Westcott JL, Kemp JF, Sian L, et al. Zinc (Zn) absorption from SprinklesTM is not affected by iron (Fe) in Kenyan infants in malaria endemic area. FASEB J. 2013; 27:107.3. Available from: http://www.fasebj.
org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/107.3
80 Kennedy G, Hambidge KM, Manary M. A Reduced phytate diet does not reduce endogenous fecal zinc in children on a habitual high-phytate diet. J Pediatr Gastroenterol Nutr. 2010; 55:678–9.
81 Hambidge KM, Mazariegos M, Solomons NW, Westcott JE, Lei S, Raboy V, et al. Intestinal excretion of endogenous zinc in Guatemalan school children. J Nutr. 2007; 137:1747–9.
82 Kodkany BS, Bellad RM, Mahantshetti NS, Westcott JE, Krebs NF, Kemp JF, et al. Biofortification of pearl millet with iron and zinc in a randomized controlled trial increases absorption of these minerals above physiologic requirements in young children. J Nutr. 2013; 143:1489–93.