Una guía para la práctica clínica | 06 FEB 24

Amenorrea hipotalámica funcional

Causa frecuente de amenorrea secundaria en mujeres fértiles no embarazadas.
Autor/a: Mariam Saadedine, Ekta Kapoor, Chrisandra Shufelt Mayo Clin Proc. n September 2023;98(9):1376-1385.
INDICE:  1. Texto principal | 2. Referencias bibliográficas
Referencias bibliográficas

1. Shufelt CL, Torbati T, Dutra E. Hypothalamic amenorrhea and the long-term health consequences. Semin Reprod Med. 2017; 35(3):256-262.

2. Gordon CM. Functional hypothalamic amenorrhea. N Engl J Med. 2010;363(4):365-371.

3. Gordon CM, Ackerman KE, Berga SL, et al. Functional hypothalamic amenorrhea: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2017;102(5):1413-1439.

4. Morrison AE, Fleming S, Levy MJ. A review of the pathophysiology of functional hypothalamic amenorrhoea in women subject to psychological stress, disordered eating, excessive exercise or a combination of these factors. Clin Endocrinol (Oxf). 2021;95(2):229-238.

5. Loucks AB. Energy availability, not body fatness, regulates reproductive function in women. Exerc Sport Sci Rev. 2003; 31(3):144-148.

6. Loucks AB, Verdun M, Heath EM. Low energy availability, not stress of exercise, alters LH pulsatility in exercising women. J Appl Physiol (1985). 1998;84(1):37-46.

7. Fontana L, Garzia E, Marfia G, Galiano V, Miozzo M. Epigenetics of functional hypothalamic amenorrhea. Front Endocrinol (Lausanne). 2022;13:953431.

8. Podfigurna A, Maciejewska-Jeske M, Meczekalski B, Genazzani AD. Kisspeptin and LH pulsatility in patients with functional hypothalamic amenorrhea. Endocrine. 2020;70(3): 635-643.

9. Meczekalski B, Niwczyk O, Bala G, Szeliga A. Stress, kisspeptin, and functional hypothalamic amenorrhea. Curr Opin Pharmacol. 2022;67:102288.

10. Iwasa T, Matsuzaki T, Yano K, et al. Effects of low energy availability on reproductive functions and their underlying neuroendocrine mechanisms. J Clin Med. 2018;7(7):166.

11. Loucks AB, Thuma JR. Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women. J Clin Endocrinol Metab. 2003;88(1):297-311.

12. Schneider LF, Warren MP. Functional hypothalamic amenorrhea is associated with elevated ghrelin and disordered eating. Fertil Steril. 2006;86(6):1744-1749.

13. Warren MP, Voussoughian F, Geer EB, Hyle EP, Adberg CL, Ramos RH. Functional hypothalamic amenorrhea: hypoleptinemia and disordered eating. J Clin Endocrinol Metab. 1999;84(3):873-877.

14. Podfigurna-Stopa A, Pludowski P, Jaworski M, Lorenc R, Genazzani AR, Meczekalski B. Skeletal status and body composition in young women with functional hypothalamic amenorrhea. Gynecol Endocrinol. 2012;28(4):299-304.

15. Caronia LM, Martin C, Welt CK, et al. A genetic basis for Functional hypothalamic amenorrhea. N Engl J Med. 2011;364(3): 215-225.

16. Podfigurna-Stopa A, Casarosa E, Luisi M, Czyzyk A, Meczekalski B, Genazzani AR. Decreased plasma concentrations of brain-derived neurotrophic factor (BDNF) in patients with functional hypothalamic amenorrhea [published correction appears in Gynecol Endocrinol. 2014;30(1):82]. Gynecol Endocrinol. 2013;29(9):817-820

17. Pedreira CC, Maya J, Misra M. Functional hypothalamic amenorrhea: impact on bone and neuropsychiatric outcomes. Front Endocrinol (Lausanne). 2022;13:953180.

18. Heaney RP, Abrams S, Dawson-Hughes B, et al. Peak bone mass. Osteoporos Int. 2000;11(12):985-1009.

19. Hara Y, Waters EM, McEwen BS, Morrison JH. Estrogen effects on cognitive and synaptic health over the lifecourse. Physiol Rev.

2015;95(3):785-807. 20. Iorga A, Cunningham CM, Moazeni S, Ruffenach G, Umar S, Eghbali M. The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biol Sex Differ. 2017;8(1):33.

 

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