Lp(a) está determinada casi exclusivamente por el gen LPA (No baja con dieta, ejercicio ni estatinas). Es estructuralmente homóloga al plasminógeno. Tiene múltiples dominios kringle IV. No tiene función fisiológica clara
-Introduce un fenotipo protrombótico e inflamatorio
❤️Fenotipo protrombótico: Compite con el plasminógeno/ Inhibe la fibrinólisis / Favorece trombos más persistentes.
💙Fenotipo proinflamatorio: Transporta fosfolípidos oxidados en gran cantidad 👉 Estimula macrófagos, endotelio y músculo liso.
RESUMEN
La Lp(a) no es una LDL alta: Es una lipoproteína aterotrombótica, genéticamente determinada, que combina colesterol + inflamación + trombosis
y explica gran parte del riesgo residual.
👉 Medir Lp(a) al menos una vez en la vida en todo adulto.(Recordar, es de origen genetico, no varia con el tiempo, no depende del ayuno).
👉 Valores de Referencia: < 30 mg/dL o < 75 nmol/L (NORMAL)
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