GLP‑1 y endoscopia alta: riesgo de contenido gástrico retenido (OCULUS)
El ensayo clínico aleatorizado OCULUS evaluó a 68 pacientes en tratamiento estable con agonistas GLP‑1/GLP‑1+GIP sometidos a endoscopia alta, ecoendoscopia o ERCP.
📉Continuar el GLP‑1 hasta el procedimiento se asoció con un 25 % de casos con volumen gástrico residual clínicamente significativo frente a 3,1 % cuando se omitió la última dosis, y todos los episodios impidieron una exploración adecuada, aunque sin aspiración ni intubación no planificada.
🔎En el subgrupo con dieta líquida clara y preparación de colon (endoscopia alta + colonoscopia) no se observaron eventos, sugiriendo que una estrategia de dieta líquida estricta podría permitir mantener el fármaco en algunos contextos, a la espera de más evidencia.
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