Mecanismos y consecuencias | 20 ENE 19

Uso de marihuana durante el embarazo y la lactancia

Sus efectos en el feto, el lactante y el niño
Autor/a: Sheryl A. Ryan, Seth D. Ammerman, Mary E. O’Connor Pediatrics. 2018;142(3)
INDICE:  1. Página 1 | 2. Página 2
Página 2


1. National Survey on Drug Use and Health. Available at: collect/nsduh-national-survey-drug-use-andhealth. Accessed September 7, 2017

2. Lester BM, El Sohly M, Wright LL, et al. The Maternal Lifestyle Study: drug use by meconium toxicology and maternal self-report. Pediatrics.2001;107(2):309–317

3. Williamson S, Jackson L, Skeoch C, Azzim G, Anderson R. Determination of the prevalence of drug misuse by meconium analysis. Arch Dis Child Fetal Neonatal Ed.2006;91(4):F291–F292

4. Passey ME, Sanson-Fisher RW, D’Este CA, Stirling JM. Tobacco, alcohol and cannabis use during pregnancy: clustering of risks. Drug Alcohol Depend. 2014;134:44–50

5. Committee on Obstetric Practice. Committee opinion no.722: marijuana use during pregnancy and lactation. Obstet Gynecol.2017;130(4):e205–e209

6. Schempf AH, Strobino DM. Drug use and limited prenatal care: an examination of responsible barriers. Am J Obstet Gynecol. 2009;200(4):412.e1–412.e10

7. Brown QL, Sarvet AL, Shmulewitz D, Martins SS, Wall MM, Hasin DS. Trends in marijuana use among pregnant and non pregnant reproductive aged women, 2002-2014. JAMA.2017;317(2):207–209

8. Vermont Department of Health. Marijuana use before, during, and after pregnancy. Available at: Accessed October 19, 2017

9. Roberson EK, Patrick WK, Hurwitz EL. Marijuana use and maternal experiences of severe nausea during pregnancy in Hawai’i. Hawaii J Med Public Health. 2014;73(9):283–287

10. Beatty JR, Svikis DS, Ondersma SJ. Prevalence and perceived financial costs of marijuana versus tobacco use among urban low-income pregnant women. J Addict Res Ther.2012;3(4):100–135

11. Moore DG, Turner JD, Parrott AC, et al. During pregnancy, recreational drug-using women stop taking ecstasy (3,4-methylenedioxy-Nmethylamphetamine) and reduce alcohol consumption, but continue to smoke tobacco and cannabis: initial findings from the Development and Infancy Study. J Psychopharmacol.2010;24(9):1403–1410

12. Forray A, Merry B, Lin H, Ruger JP, Yonkers KA. Perinatal substance use: a prospective evaluation of abstinence and relapse. Drug Alcohol Depend.2015;150:147–155

13. Mark K, Desai A, Terplan M. Marijuana use and pregnancy: prevalence, associated characteristics, and birth outcomes. Arch Women Ment Health.2016;19(1):105–111

14. El Marroun H, Tiemeier H, Steegers EA, et al. Intrauterine cannabis exposure affects fetal growth trajectories: the Generation R Study. J Am Acad Child Adolesc Psychiatry. 2009;48(12):1173–1181

15. van Gelder MM, Reefhuis J, Caton AR, Werler MM, Druschel CM, Roeleveld N; National Birth Defects Prevention Study. Characteristics of pregnant illicit drug users and associations between cannabis use and perinatal outcome in a population based study. Drug Alcohol Depend.2010;109(1–3):243–247

16. Alhusen JL, Lucea MB, Bullock L, Sharps P. Intimate partner violence, substance use, and adverse neonatal outcomes among urban women. J Pediatr. 2013;163(2):471–476

17. American Academy of Pediatrics; American College of Obstetricians and Gynecologists. Guidelines for Perinatal Care. 8th ed. Elk Grove Village, IL: American Academy of Pediatrics; and Washington, DC: American College of Obstetricians and Gynecologists; 2017

18. Volkow ND, Compton WM, Wargo EM. The risks of marijuana use during pregnancy. JAMA. 2017;317(2):129–130

19. Westfall RE, Janssen PA, Lucas P, Capler R. Survey of medicinal cannabis use among childbearing women: patterns of its use in pregnancy and retroactive self-assessment of its efficacy against‘ morning sickness’. Complement Ther Clin Pract. 2006;12(1):27–33

20. Tortoriello G, Morris CV, Alpar A, et al. Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO J. 2014;33(7):668–685

21. Feinshtein V, Erez O, Ben-Zvi Z, et al. Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. Am J Obstet Gynecol.2013;209(6):573.e1–573.e15

22. El Marroun H, Tiemeier H, Steegers EA, et al. A prospective study on intrauterine cannabis exposure and fetal blood flow. Early Hum Dev.2010;86(4):231–236

23. Loebstein R, Lalkin A, Koren G. Pharmacokinetic changes during pregnancy and their clinical relevance. Clin Pharmacokinet.1997;33(5):328–343

24. Grotenhermen F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet.2003;42(4):327–360

25. Hutchings DE, Martin BR, Gamagaris Z, Miller N, Fico T. Plasma concentrations of delta-9-tetrahydrocannabinol in dams and fetuses following acute or multiple prenatal dosing in rats. Life Sci. 1989;44(11):697–701

26. Boskovic R, Klein J, Woodland C, Karaskov T, Koren G. The role of the placenta in variability of fetal exposure to cocaine and cannabinoids: a twin study. Can J Physiol Pharmacol.2001;79(11):942–945

27. Wu TC, Tashkin DP, Djahed B, Rose JE. Pulmonary hazards of smoking marijuana as compared with tobacco. N Engl J Med. 1988;318(6):347–3512

8. Gunn JK, Rosales CB, Center KE, et al. Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis. BMJ Open. 2016;6(4):e009986

29. Conner SN, Bedell V, Lipsey K, Macones GA, Cahill AG, Tuuli MG. Maternal marijuana use and adverse neonatal outcomes: a systematic review and meta-analysis. Obstet Gynecol.2016;128(4):713–723

30. Fried PA. Marihuana use by pregnant women and effects on offspring: an update. Neurobehav Toxicol Teratol.1982;4(4):451–454

31. Fried PA. The Ottawa Prenatal Prospective Study (OPPS):methodological issues and findings–it’s easy to throw the baby out with the bath water. Life Sci.1995;56(23–24):2159–2168

32. Richardson GA, Day NL, Taylor PM. The effect of prenatal alcohol, marijuana and tobacco exposure on neonatal behavior. Infant Behav Dev.1989;12(2):199–209

33. Fergusson DM, Horwood LJ, Northstone K; Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC) Study Team. Maternal use of cannabis and pregnancy outcome. BJOG.2002;109(1):21–27

34. Fried PA, Watkinson B, Willan A. Marijuana use during pregnancy and decreased length of gestation. Am J Obstet Gynecol. 1984;150(1):23–27

35. Day N, Sambamoorthi U, Taylor P, et al. Prenatal marijuana use and neonatal outcome. Neurotoxicol Teratol.1991;13(3):329–334

36. Chabarria KC, Racusin DA, Antony KM, et al. Marijuana use and its effects in pregnancy. Am J Obstet Gynecol.2016;215(4):506.e1–506.e7

37. Dotters-Katz SK, Smid MC, Manuck TA, Metz TD. Risk of neonatal and childhood morbidity among preterm infants exposed to marijuana. J Matern Fetal Neonatal Med.2017;30(24):2933–2939

38. van Gelder MM, Reefhuis J, Caton AR, Werler MM, Druschel CM, Roeleveld N; National Birth Defects Prevention Study. Maternal periconceptional illicit drug use and the risk of congenital malformations. Epidemiology.2009;20(1):60–66

39. de Moraes Barros MC, Guinsburg R, de Araújo Peres C, Mitsuhiro S, Chalem E, Laranjeira RR. Exposure to marijuana during pregnancy alters neurobehavior in the early neonatal period. J Pediatr. 2006;149(6):781–787

40. Fried PA, Watkinson B, Dillon RF, Dulberg CS. Neonatal neurological status in a low-risk population after prenatal exposure to cigarettes, marijuana, and alcohol. J Dev Behav Pediatr. 1987;8(6):318–326

41. Fried PA, Makin JE. Neonatal behavioural correlates of prenatal exposure to marihuana, cigarettes and alcohol in a low risk population. Neurotoxicol Teratol. 1987;9(1):1–7

42. Lester BM, Dreher M. Effects of marijuana use during pregnancy on newborn cry. Child Dev.1989;60(4):765–771

43. Scher MS, Richardson GA, Coble PA, Day NL, Stoffer DS. The effects of prenatal alcohol and marijuana exposure: disturbances in neonatal sleep cycling and arousal. Pediatr Res.1988;24(1):101–105

44. Dreher MC, Nugent K, Hudgins R. Prenatal marijuana exposure and neonatal outcomes in Jamaica: an ethnographic study. Pediatrics.1994;93(2):254–260

45. Fried PA, Watkinson B. 36- and 48-month neurobehavioral follow-up of children prenatally exposed to marijuana, cigarettes, and alcohol. J Dev Behav Pediatr. 1990;11(2):49–58

46. Fried PA, O’Connell CM, Watkinson B.60- and 72-month follow-up of children prenatally exposed to marijuana, cigarettes, and alcohol: cognitive and language assessment. J Dev Behav Pediatr. 1992;13(6):383–391

47. Fried PA, Watkinson B, Gray R. A follow-up study of attentional behavior in 6-year-old children exposed prenatally to marihuana, cigarettes, and alcohol. Neurotoxicol Teratol.1992;14(5):299–311

48. Fried PA. Behavioral outcomes in preschool and school-age children exposed prenatally to marijuana: a review and speculative interpretation. NIDA Res Monogr. 1996;164:242–260

49. Fried PA, Watkinson B, Siegel LS. Reading and language in 9- to 12-year olds prenatally exposed to cigarettes and marijuana. Neurotoxicol Teratol.1997;19(3):171–183

50. Fried PA, Watkinson B, Gray R. Differential effects on cognitive functioning in 9- to 12-year olds prenatally exposed to cigarettes and marihuana. Neurotoxicol Teratol.1998;20(3):293–306



Para ver los comentarios de sus colegas o para expresar su opinión debe ingresar con su cuenta de IntraMed.

Términos y condiciones de uso | Todos los derechos reservados | Copyright 1997-2023