Cómo aconsejar, cuándo derivar a especialistas y cirugía | 26 AGO 18

Aneurisma de la aorta torácica

Cursa de manera silenciosa y progresa lentamente hasta un punto de inflexión, tras el cual el diámetro aórtico se agranda con mayor rapidez, pudiendo terminar en disección o ruptura aórtica
INDICE:  1. Página 1 | 2. Referencias bibliográficas
Referencias bibliográficas

1. Elefteriades JA, Farkas EA. Thoracic aortic aneurysm clinically pertinent controversies and uncertainties. J Am Coll Cardiol 2010; 55(9):841–857. doi:10.1016/j.jacc.2009.08.084

2. Hiratzka LF, Bakris GL, Beckman JA, et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: executive summary. Anesth Analg 2010; 111(2):279–315. doi:10.1213/ANE.0b013e3181dd869b

3. Clouse WD, Hallett JW Jr, Schaff HV, Gayari MM, Ilstrup DM, Melton LJ 3rd. Improved prognosis of thoracic aortic aneurysms: a population- based study. JAMA 1998; 280(22):1926–1929. pmid:9851478

4. Olsson C, Thelin S, Ståhle E, Ekbom A, Granath F. Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14,000 cases from 1987 to 2002. Circulation 2006; 114(24):2611–2618. doi:10.1161/CIRCULATIONAHA.106.630400

5. Clouse WD, Hallett JW Jr, Schaff HV, et al. Acute aortic dissection: population-based incidence compared with degenerative aortic aneurysm rupture. Mayo Clin Proc 2004; 79(2):176–180. pmid:14959911

6. US Centers for Disease Control and Prevention (CDC). National Center for Injury Prevention and Control. WISQARS leading causes of death reports, 1999 – 2007. https://webappa.cdc.gov/sasweb/ncipc/ leadcaus10.html. Accessed May 21, 2018.

7. Hansen MS, Nogareda GJ, Hutchison SJ. Frequency of and inappropriate

treatment of misdiagnosis of acute aortic dissection. Am J Cardiol 2007; 99(6):852–856. doi:10.1016/j.amjcard.2006.10.055

8. Goldfinger JZ, Halperin JL, Marin ML, Stewart AS, Eagle KA, Fuster V. Thoracic aortic aneurysm and dissection. J Am Coll Cardiol 2014;

64(16):1725–1739. doi:10.1016/j.jacc.2014.08.025

9. Kumar V, Abbas A, Aster J. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Elsevier/Saunders; 2015.

10. Wolak A, Gransar H, Thomson LE, et al. Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area. JACC Cardiovasc Imaging 2008; 1(2):200–209. doi:10.1016/j.jcmg.2007.11.005

11. Elefteriades JA. Natural history of thoracic aortic aneurysms: indications for surgery, and surgical versus nonsurgical risks. Ann Thorac Surg 2002; 74(5):S1877–S1880; discussion S1892–S1898. pmid:12440685

12. Smith AD, Schoenhagen P. CT imaging for acute aortic syndrome. Cleve Clin J Med 2008; 75(1):7–17. Pmid :18236724

13. Cury M, Zeidan F, Lobato AC. Aortic disease in the young: genetic aneurysm syndromes, connective tissue disorders, and familial aortic aneurysms and dissections. Int J Vasc Med 2013 (2013); 2013: 267215. doi:10.1155/2013/267215

14. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002; 39(12):1890–1900. doi:10.1016/S0735-1097(02)01886-7

15. Fedak PW, Verma S, David TE, Leask RL, Weisel RD, Butany J. Clinical and pathophysiological implications of a bicuspid aortic valve. Circulation 2002; 106(8):900–904. pmid: 12186790

16. Della Corte A, Bancone C, Quarto C, et al. Predictors of ascending aortic dilatation with bicuspid aortic valve: a wide spectrum of disease expression. Eur J Cardiothorac Surg 2007; 31(3):397–405. doi:10.1016/j.ejcts.2006.12.006

17. Jackson V, Petrini J, Caidahl K, et al. Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery. Eur J Cardiothorac Surg 2011; 40(3):e118–e124. doi:10.1016/j.ejcts.2011.04.014

18. Michelena HI, Khanna AD, Mahoney D, et al. Incidence of aortic complications in patients with bicuspid aortic valves. JAMA 2011; 306 (10):1104–1112. doi:10.1001/jama.2011.1286

19. Verma S, Siu SC. Aortic dilatation in patients with bicuspid aortic valve. N Engl J Med 2014; 370 (20):1920–1929. doi:10.1056/NEJMra1207059

20. Barker AJ, Markl M, Bürk J, et al. Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta. Circ Cardiovasc Imaging 2012; 5 (4):457–466. doi:10.1161/CIRCIMAGING.112.973370

21. Hope MD, Hope TA, Meadows AK, et al. Bicuspid aortic valve: four dimensional MR evaluation of ascending aortic systolic flow patterns. Radiology 2010; 255 (1): 53–61. doi:10.1148/radiol.09091437

22. Abdulkareem N, Soppa G, Jones S, Valencia O, Smelt J, Jahangiri M.

Dilatation of the remaining aorta after aortic valve or aortic root replacement in patients with bicuspid aortic valve: a 5-year follow-up. Ann Thorac Surg 2013; 96 (1):43–49.


23. Regeer MV, Versteegh MI, Klautz RJ, et al. Effect of aortic valve replacement on aortic root dilatation rate in patients with bicuspid and tricuspid aortic valves. Ann Thorac Surg 2016; 102 (6):1981–1987. doi:10.1016/j.athoracsur.2016.05.038

24. Habashi JP, Judge DP, Holm TM, et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 2006; 312 (5770):117–121. doi:10.1126/science.1124287

25. Brooke BS, Habashi JP, Judge DP, Patel N, Loeys B, Dietz HC 3rd. Angiotensin

II blockade and aortic-root dilation in Marfan’s syndrome. N Engl J Med 2008; 358 (26):2787–2795. doi:10.1056/NEJMoa0706585

26. Chiu HH, Wu MH, Wang JK, et al. Losartan added to ß-blockade therapy for aortic root dilation in Marfan syndrome: a randomized, open-label pilot study. Mayo Clin Proc 2013; 88(3): 271–276. doi:10.1016/j.mayocp.2012.11.005

27. Groenink M, den Hartog AW, Franken R, et al. Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial. Eur Heart J 2013; 34(45): 3491–3500. doi:10.1093/eurheartj/eht334

28. Lacro RV, Dietz HC, Sleeper LA, et al; Pediatric Heart Network Investigators. Atenolol versus losartan in children and young adults with Marfan’s syndrome. N Engl J Med 2014; 371(22):2061–2071. doi:10.1056/NEJMoa1404731

29. Ziganshin BA, Mukherjee SK, Elefteriades JA, et al. Atenolol versus losartan in Marfan’s syndrome (letters). N Engl J Med 2015; 372(10):977–981. doi:10.1056/NEJMc1500128

30. Franken R, den Hartog AW, Radonic T, et al. Beneficial outcome of losartan therapy depends on type of FBN1 mutation in Marfan syndrome. Circ Cardiovasc Genet 2015; 8(2):383–388. doi:10.1161/CIRCGENETICS.114.000950

31. Elefteriades JA. Thoracic aortic aneurysm: reading the enemy’s playbook.

Curr Probl Cardiol 2008; 33(5): 203–277. doi:10.1016/j.cpcardiol.2008.01.004

32. Idrees JJ, Roselli EE, Lowry AM, et al. Outcomes after elective proximal aortic replacement: a matched comparison of isolated versus multicomponent operations. Ann Thorac Surg 2016; 101(6):2185– 2192. doi: 10.1016/j.athoracsur.2015.12.026

33. Hiratzka LF, Creager MA, Isselbacher EM, et al. Surgery for aortic dilatation in patients with bicuspid aortic valves: a statement of clarification from the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Thorac Cardiovasc Surg 2016; 151(4):959–966. doi:10.1016/j.jtcvs.2015.12.001

34. Tzemos N, Therrien J, Yip J, et al. Outcomes in adults with bicuspid aortic valves. JAMA 2008; 300(11):1317–1325. doi:10.1001/jama.300.11.1317

35. Davies RR, Goldstein LJ, Coady MA, et al. Yearly rupture or dissection rates for thoracic aortic aneurysms: simple prediction based on size. Ann Thorac Surg 2002; 73(1):17–28. pmid:1183400736.

Nishimura RA, Otto CM, Bono RO, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American heart Association Task Force on Practice Guidelines. Circulation 2014; 129(23):2440–2492. doi:10.1161/CIR.0000000000000029

37. Wojnarski CM, Svensson LG, Roselli EE, et al. Aortic dissection in patients with bicuspid aortic valve–associated aneurysms. Ann Thorac Surg 2015; 100(5):1666–1674. doi:10.1016/j.athoracsur.2015.04.126

38. Hiratzka LF, Creager MA, Isselbacher EM, et al. Surgery for aortic dilatation in patients with bicuspid aortic valves: a statement of clarification from the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2016; 133(7):680–686. doi:10.1161/CIR.0000000000000331

39. Pape LA, Tsai TT, Isselbacher EM, et al; International Registry of Acute Aortic Dissection (IRAD) Investigators. Aortic diameter > or = 5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2007; 116(10):1120–1127. doi:10.1161/CIRCULATIONAHA.107.702720

40. Loeys BL, Schwarze U, Holm T, et al. Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med 2006; 355(8):788– 798. doi:10.1056/NEJMoa055695

41. Guo DC, Pannu H, Tran-Fadulu V, et al. Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections. Nat Genet 2007; 39(12):1488–1493. doi:10.1038/ng.2007.6

42. Svensson LG, Khitin L. Aortic cross-sectional area/height ratio timing of aortic surgery in asymptomatic patients with Marfan syndrome. J Thorac Cardiovasc Surg 2002; 123(2):360–361. pmid:11828302

43. Svensson LG, Kim KH, Lytle BW, Cosgrove DM. Relationship of aortic cross-sectional area to height ratio and the risk of aortic dissection in patients with bicuspid aortic valves. J Thorac Cardiovasc Surg 2003; 126(3):892–893. pmid:14502185

44. Masri A, Kalahasti V, Svensson LG, et al. Aortic cross-sectional area/height ratio and outcomes in patients with a trileaflet aortic valve and a dilated aorta. Circulation 2016; 134(22):1724–1737. doi:10.1161/CIRCULATIONAHA.116.022995



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