Restricción de hidratos de carbono y ejercicio de alta intensidad | 02 ENE 18

Estrategias que mejoran la salud cardiometabólica

La restricción de hidratos de carbono y el entrenamiento intensivo en intervalos (HIIT) mejoran independientemente la salud cardiovascular y metabólica
Autor/a: Francois ME, Gillen JB, Little JP Frontiers in Nutrition October 2017
INDICE:  1. Página 1 | 2. Referencias bibliográficas
Referencias bibliográficas

1. Guariguata L, Whiting D, Hambleton I, Beagley J, Linnenkamp U, Shaw J. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract (2014) 103(2):137–49. doi:10.1016/j.diabres.2013.11.002

2. Laakso M. Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes (1999) 48(5):937–42. doi:10.2337/diabetes.48.5.937

3. Fox CS, Coady S, Sorlie PD, D’Agostino RB, Pencina MJ, Vasan RS, et al. Increasing cardiovascular disease burden due to diabetes mellitus the Framingham Heart Study. Circulation (2007) 115(12):1544–50. doi:10.1161/CIRCULATIONAHA.106.658948

4. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK. Cardiovascular risk factors in confirmed prediabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA (1990) 263(21):2893–8. doi:10.1001/jama.263.21.2893

5. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med (1998) 15(7):539–53. doi:10.1002/(SICI)1096-9136(199807)15:7<539::AIDDIA668>3.0.CO;2-S

6. Warburton DE, Nicol CW, Bredin SS. Health benefits of physical activity: the evidence. Can Med Assoc J (2006) 174(6):801–9. doi:10.1503/cmaj.051351

7. Diabetes Prevention Program Research Group, Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, et al. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet (2009) 374(9702):1677–86. doi:10.1016/S0140-6736(09)61457-4

8. Wing R, Bolin P, Brancati F, Bray G, Clark J, Coday M, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med (2013) 369(2):145–54. doi:10.1056/NEJMoa1212914

9. Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Dempsey PC, et al. Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes Care (2016) 39(11):2065–79.

10. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome. Circulation (2005) 112(17):2735–52. doi:10.1161/CIRCULATIONAHA.105.169405

11. Inzucchi SE, Bergenstal R, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia (2012) 55(6):1577–96. doi:10.1007/s00125-012-2534-0

12. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 346: 393–403. doi:10.1056/NEJMoa012512

13. Jung ME, Bourne JE, Beauchamp MR, Robinson E, Little JP. High-intensity interval training as an efficacious alternative to moderate-intensity continuous training for adults with prediabetes. J Diabetes Res (2015) 2015:9.

14. Hu T, Yao L, Reynolds K, Niu T, Li S, Whelton P, et al. Adherence to lowcarbohydrate and low-fat diets in relation to weight loss and cardiovascular risk factors. Obes Sci Pract (2016) 2(1):24–31. doi:10.1002/osp4.23

15. Kennedy ET, Bowman SA, Powell R. Dietary-fat intake in the US population. J Am Coll Nutr (1999) 18(3):207–12. doi:10.1080/07315724.1999.10 718853

16. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP. The continuing epidemics of obesity and diabetes in the United States. JAMA (2001) 286(10):1195–200. doi:10.1001/jama.286.10.1195

17. Noakes TD, Windt J. Evidence that supports the prescription of lowcarbohydrate high-fat diets: a narrative review. Br J Sports Med (2017) 51(2): 133–9. doi:10.1136/bjsports-2016-096491

18. Coulston AM, Hollenbeck CB, Swislocki AL, Chen YI, Reaven GM. Deleterious metabolic effects of high-carbohydrate, sucrose-containing diets in patients with non-insulin-dependent diabetes mellitus. Am J Med (1987) 82(2):213–20. doi:10.1016/0002-9343(87)90058-1

19. Garg A, Grundy SM, Koffler M. Effect of high carbohydrate intake on hyperglycemia, islet function, and plasma lipoproteins in NIDDM. Diabetes Care (1992) 15(11):1572–80. doi:10.2337/diacare.15.11.1572

20. Reaven GM. The role of insulin resistance and hyperinsulinemia in coronary heart disease. Metabolism (1992) 41(5):16–9. doi:10.1016/0026- 0495(92)90088-R

21. American Diabetes Association. Nutrition recommendations and interventions for diabetes. Diabetes Care (2008) 31(Suppl 1):S61–78. doi:10.2337/dc08-S061

22. Samaha FF, Iqbal N, Seshadri P, Chicano KL, Daily DA, McGrory J, et al. A low-carbohydrate as compared with a low-fat diet in severe obesity. N Engl J Med (2003) 348(21):2074–81. doi:10.1056/NEJMoa022637

23. Volek JS, Sharman MJ, Gómez AL, Judelson DA, Rubin MR, Watson G, et al. Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women. Nutr Metab (2004) 1(1):13. doi:10.1186/1743-7075-1-13

24. Forsythe CE, Phinney SD, Fernandez ML, Quann EE, Wood RJ, Bibus DM, et al. Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation. Lipids (2008) 43(1):65–77. doi:10.1007/s11745-007-3132-7

25. Westman EC, Yancy WS, Mavropoulos JC, Marquart M, McDuffie JR. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Nutr Metab (2008) 5(1):36. doi:10.1186/1743-7075-5-36

26. Boden G, Sargrad K, Homko C, Mozzoli M, Stein TP. Effect of a lowcarbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes. Ann Intern Med (2005) 142(6):403–11. doi:10.7326/0003-4819-142-6-200503150-00006

27. Dyson P, Beatty S, Matthews D. A low-carbohydrate diet is more effective in reducing body weight than healthy eating in both diabetic and nondiabetic subjects. Diabet Med (2007) 24(12):1430–5. doi:10.1111/j.1464-5491. 2007.02290.x

28. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, et al. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition (2015) 31(1):1–13. doi:10.1016/j.nut.2014.06.011

29. Gannon MC, Nuttall FQ. Control of blood glucose in type 2 diabetes without weight loss by modification of diet composition. Nutr Metab (2006) 3(1):16. doi:10.1186/1743-7075-3-16

30. Nuttall FQ, Schweim K, Hoover H, Gannon MC. Effect of the LoBAG 30 diet on blood glucose control in people with type 2 diabetes. Br J Nutr (2008) 99(03):511–9. doi:10.1017/S0007114507819155

31. Accurso A, Bernstein RK, Dahlqvist A, Draznin B, Feinman RD, Fine EJ, et al. Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal. Nutr Metab (2008) 5(1):9. doi:10.1186/1743-7075-5-9

32. Paoli A, Rubini A, Volek J, Grimaldi K. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr (2013) 67(8):789–96. doi:10.1038/ejcn.2013.116

33. Cornier MA, Donahoo WT, Pereira R, Gurevich I, Westergren R, Enerback S, et al. Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women. Obes Res (2005) 13(4):703–9. doi:10.1038/oby.2005.79

34. Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services (2014).

35. Stern L, Iqbal N, Seshadri P, Chicano KL, Daily DA, McGrory J, et al. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med (2004) 140(10):778–85. doi:10.7326/0003-4819-140-10-200405180-00007

36. Meckling KA, O’Sullivan C, Saari D. Comparison of a low-fat diet to a low carbohydrate diet on weight loss, body composition, and risk factors for diabetes and cardiovascular disease in free-living, overweight men and women. J Clin Endocrinol Metab (2004) 89(6):2717–23. doi:10.1210/jc.2003-031606

37. Yancy WS, Westman EC, McDuffie JR, Grambow SC, Jeffreys AS, Bolton J, et al. A randomized trial of a low-carbohydrate diet vs orlistat plus a low-fat diet for weight loss. Arch Intern Med (2010) 170(2):136–45. doi:10.1001/ archinternmed.2009.492

38. Bianchi C, Miccoli R, Penno G, Del Prato S. Primary prevention of cardiovascular disease in people with dysglycemia. Diabetes Care (2008) 31(Suppl 2):S208–14. doi:10.2337/dc08-s256.

39. Gannon MC, Hoover H, Nuttall FQ. Further decrease in glycated hemoglobin following ingestion of a LoBAG 30 diet for 10 weeks compared to 5 weeks in people with untreated type 2 diabetes. Nutr Metab (2010) 7(1):64. doi:10.1186/1743-7075-7-64

40. Nuttall FQ, Almokayyad RM, Gannon MC. Comparison of a carbohydrate free diet vs. fasting on plasma glucose, insulin and glucagon in type 2 diabetes. Metabolism (2015) 64(2):253–62. doi:10.1016/j.metabol.2014.10.004

41. Alarcon C, Boland BB, Uchizono Y, Moore PC, Peterson B, Rajan S, et al. Pancreatic β-cell adaptive plasticity in obesity increases insulin production but adversely affects secretory function. Diabetes (2016) 65(2):438–50. doi:10.2337/db15-0792

42. Little JP, Myette-Côté É. Comment on Alarcon et al. Pancreatic β-cell adaptive plasticity in obesity increases insulin production but adversely affects secretory function. Diabetes 2016; 65: 438–450. Diabetes (2016) 65(8):e28. doi:10.2337/db16-0492

43. Blair SN. Physical inactivity: the biggest public health problem of the 21st century. Br J Sports Med (2009) 43(1):1–2.

44. Kohl HW, Craig CL, Lambert EV, Inoue S, Alkandari JR, Leetongin G, et al. The pandemic of physical inactivity: global action for public health. Lancet (2012) 380(9838):294–305. doi:10.1016/S0140-6736(12)60898-8

45. Hawley JA, Hargreaves M, Joyner MJ, Zierath JR. Integrative biology of exercise. Cell (2014) 159(4):738–49. doi:10.1016/j.cell.2014.10.029

46. Pedersen BK, Saltin B. Exercise as medicine-evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports (2015) 25(S3):1–72. doi:10.1111/sms.12581

47. Kaminsky LA, Arena R, Beckie TM, Brubaker PH, Church TS, Forman DE, et al. The importance of cardiorespiratory fitness in the United States: the need for a national registry. Circulation (2013) 127(5):652–62. doi:10.1161/ CIR.0b013e31827ee100

48. Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA (2009) 301(19): 2024–35. doi:10.1001/jama.2009.681

49. Lee D-C, Sui X, Artero EG, Lee I-M, Church TS, McAuley PA, et al. Longterm effects of changes in cardiorespiratory fitness and body mass index on all-cause and cardiovascular disease mortality in men. Circulation (2011) 124(23):2483–90. doi:10.1161/CIRCULATIONAHA.111.038422

50. Gormley SE, Swain DP, High R, Spina RJ, Dowling EA, Kotipalli US, et al. Effect of intensity of aerobic training on VO2max. Med Sci Sports Exerc (2008) 40(7):1336–43. doi:10.1249/01.mss.0000321629.41403.46

51. Ross R, de Lannoy L, Stotz PJ. Separate effects of intensity and amount of exercise on interindividual cardiorespiratory fitness response. Mayo Clin Proc (2015) 90:1506–14. doi:10.1016/j.mayocp.2015.07.024

52. Boulé NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA (2001) 286(10):1218–27. doi:10.1001/jama.286.10.1218

53. Boulé N, Kenny G, Haddad E, Wells G, Sigal R. Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in type 2 diabetes mellitus. Diabetologia (2003) 46(8):1071–81. doi:10.1007/s00125-003-1160-2

54. Snowling NJ, Hopkins WG. Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients. Diabetes Care (2006) 29(11):2518–27. doi:10.2337/dc06-1317

55. Marwick TH, Hordern MD, Miller T, Chyun DA, Bertoni AG, Blumenthal RS, et al. Exercise training for type 2 diabetes mellitus. Circulation (2009) 119(25):3244–62. doi:10.1161/CIRCULATIONAHA.109.192521

56. Baldi JC, Wilson GA, Wilson LC, Wilkins GT, Lamberts RR. The type 2 diabetic heart: its role in exercise intolerance and the challenge to find effective exercise interventions. Sports Med (2016) 46(11):1–13. doi:10.1007/s40279-016-0542-9

57. Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee I-M, et al. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc (2011) 43(7):1334–59. doi:10.1249/MSS.0b013e318213fefb

58. Gibala MJ, Little JP, MacDonald MJ, Hawley JA. Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol (2012) 590(5):1077–84. doi:10.1113/jphysiol.2011.224725

59. Weston KS, Wisloff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med (2014) 48(16):1227–34. doi:10.1136/ bjsports-2013-092576

60. Jelleyman C, Yates T, O’Donovan G, Gray L, King JA, Khunti K, et al. The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis. Obes Rev (2015) 16(11):942–61. doi:10.1111/obr.12317

61. Ramos JS, Dalleck LC, Tjonna AE, Beetham KS, Coombes JS. The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis. Sports Med (2015) 45(5):679–92. doi:10.1007/s40279-015-0321-z

62. Tjonna AE, Lee SJ, Rognmo O, Stolen TO, Bye A, Haram PM, et al. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome. Circulation (2008) 118(4):346–54. doi:10.1161/ CIRCULATIONAHA.108.772822

63. Hollekim-Strand SM, Bjorgaas MR, Albrektsen G, Tjonna AE, Wisloff U, Ingul CB. High-intensity interval exercise effectively improves cardiac function in patients with type 2 diabetes mellitus and diastolic dysfunction. J Am Coll Cardiol (2014) 64(16):1758. doi:10.1016/j.jacc.2014.07.971

64. Stoa EM, Meling S, Nyhus L-K, Stromstad G, Mangerud KM, Helgerud J, et al. High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes. Eur J Appl Physiol (2017) 117(3):455–67. doi:10.1007/s00421-017-3540-1

65. Karstoft K, Winding K, Knudsen SH, Nielsen JS, Thomsen C, Pedersen BK, et al. The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetic patients a randomized, controlled trial. Diabetes Care (2013) 36(2):228–36. doi:10.2337/ dc12-0658

66. Apostolopoulou M, Röhling M, Gancheva S, Jelenik T, Kaul K, Bierwagen A, et al. High-intensity interval training improves peripheral insulin sensitivity and mitochondrial respiration in patients with type 2 diabetes. Diabetol Stoffwechsel (2016) 11(S 01):FV8. doi:10.1055/s-0036-1580755

67. Karstoft K, Winding K, Knudsen SH, James NG, Scheel MM, Olesen J, et al. Mechanisms behind the superior effects of interval vs continuous training on glycaemic control in individuals with type 2 diabetes: a randomized controlled trial. Diabetologia (2014) 57(10):2081–93. doi:10.1007/s00125-014-3334-5

68. Garber AJ, Duncan TG, Goodman AM, Mills DJ, Rohlf JL. Efficacy of metformin in type II diabetes: results of a double-blind, placebo-controlled, dose-response trial. Am J Med (1997) 103(6):491–7. doi:10.1016/S0002-9343(97)00254-4

69. Madsen SM, Thorup AC, Overgaard K, Jeppesen PB. High intensity interval training improves glycaemic control and pancreatic β cell function of type 2 diabetes patients. PLoS One (2015) 10(8):e0133286. doi:10.1371/journal.pone.0133286

70. Cassidy S, Thoma C, Hallsworth K, Parikh J, Hollingsworth KG, Taylor R, et al. High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial. Diabetologia (2016) 59(1):56–66. doi:10.1007/s00125-015-3741-2

71. Trost SG, Owen N, Bauman AE, Sallis JF, Brown W. Correlates of adults’ participation in physical activity: review and update. Med Sci Sports Exerc (2002) 34(12):1996–2001. doi:10.1097/00005768-200212000-00020

72. Little JP, Gillen JB, Percival ME, Safdar A, Tarnopolsky MA, Punthakee Z, et al. Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol (2011) 111(6):1554–60. doi:10.1152/japplphysiol.00921.2011

73. Francois ME, Durrer C, Pistawka KJ, Halperin FA, Chang C, Little JP. Combined interval training and post-exercise nutrition in type 2 diabetes: a randomized control trial. Front Physiol (2017) 8:528. doi:10.3389/fphys.2017.00528

74. Revdal A, Hollekim-Strand SM, Ingul CB. Can time efficient exercise improve cardiometabolic risk factors in type 2 diabetes? A pilot study. J Sports Sci Med (2016) 15(2):308.

75. Little JP, Safdar A, Bishop D, Tarnopolsky MA, Gibala MJ. An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol (2011) 300(6):R1303–10. doi:10.1152/ajpregu.00538.2010

76. Little JP, Jung ME, Wright AE, Wright W, Manders RJ. Effects of highintensity interval exercise versus continuous moderate-intensity exercise on postprandial glycemic control assessed by continuous glucose monitoring in obese adults. Appl Physiol Nutr Metab (2014) 39(7):835–41. doi:10.1139/ apnm-2013-0512

77. Martinez N, Kilpatrick MW, Salomon K, Jung ME, Little JP. Affective and enjoyment responses to high-intensity interval training in overweight-to obese and insufficiently active adults. J Sport Exerc Psychol (2015) 37(2): 138–49. doi:10.1123/jsep.2014-0212

78. Little JP, Francois ME. High-intensity interval training for improving postprandial hyperglycemia. Res Q Exerc Sport (2014) 85(4):451–6.

79. MacInnis MJ, Gibala MJ. Physiological adaptations to interval training and the role of exercise intensity. J Physiol (2016) 595(9):2915–30. doi:10.1113/JP273196

80. Jiménez-Pavón D, Lavie CJ. Response: commentary: high-intensity intermittent training vs. moderate-intensity intermittent training: is it a matter of intensity or intermittent efforts? Front Physiol (2017) 8:526. doi:10.3389/ fphys.2017.00526

81. Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ, Storlien LH. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes (1991) 40(11):1397–403. doi:10.2337/diabetes. 40.11.1397

82. Lamont B, Waters M, Andrikopoulos S. A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice. Nutr Diabetes (2016) 6(2):e194. doi:10.1038/nutd.2016.2

83. Vessby B, Uusitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC, et al. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU study. Diabetologia (2001) 44(3):312–9.

84. Riccardi G, Giacco R, Rivellese A. Dietary fat, insulin sensitivity and the metabolic syndrome. Clin Nutr (2004) 23(4):447–56. doi:10.1016/j.clnu. 2004.02.006

85. Numao S, Kawano H, Endo N, Yamada Y, Konishi M, Takahashi M, et al. Short-term low carbohydrate/high-fat diet intake increases postprandial plasma glucose and glucagon-like peptide-1 levels during an oral glucose tolerance test in healthy men. Eur J Clin Nutr (2012) 66(8):926–31. doi:10.1038/ ejcn.2012.58

86. Wan Z, Durrer C, Mah D, Simtchouk S, Robinson E, Little JP. Reduction of AMPK activity and altered MAPKs signalling in peripheral blood mononuclear cells in response to acute glucose ingestion following a short-term high fat diet in young healthy men. Metabolism (2014) 63(9):1209–16. doi:10.1016/j.metabol.2014.06.007

87. Thomas CD, Peters JC, Reed GW, Abumrad NN, Sun M, Hill J. Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans. Am J Clin Nutr (1992) 55(5):934–42.

88. Schrauwen P, van Marken Lichtenbelt W, Saris W, Westerterp KR. Changes in fat oxidation in response to a high-fat diet. Am J Clin Nutr (1997) 66(2):276–82.

89. Corpeleijn E, Saris WH, Blaak EE. Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle. Obes Rev (2009) 10(2):178–93. doi:10.1111/j.1467-789X.2008.00544.x

90. Nappo F, Esposito K, Cioffi M, Giugliano G, Molinari AM, Paolisso G, et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol (2002) 39(7):1145–50. doi:10.1016/S0735-1097(02)01741-2

91. Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA (2005) 293(1):43–53. doi:10.1001/jama.293.1.43

92. Gillen J, Little J, Punthakee Z, Tarnopolsky M, Riddell M, Gibala M. Acute high-intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes. Diabetes Obes Metab (2012) 14(6):575–7. doi:10.1111/j.1463-1326.2012.01564.x

93. Francois ME, Baldi JC, Manning PJ, Lucas SJ, Hawley JA, Williams MJ, et al. ’Exercise snacks’ before meals: a novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia (2014) 57(7):1437–45. doi:10.1007/s00125-014-3244-6

94. Sheard NF, Clark NG, Brand-Miller JC, Franz MJ, Pi-Sunyer FX, Mayer-Davis E, et al. Dietary carbohydrate (amount and type) in the prevention and management of diabetes. Diabetes Care (2004) 27(9):2266–71. doi:10.2337/diacare.27.9.2266

95. Gutniak M, Grill V, Efendlć S. Effect of composition of mixed meals-low versus high-carbohydrate content-on insulin, glucagon, and somatostatin release in healthy humans and in patients with NIDDM. Diabetes Care (1986) 9(3):244–9. doi:10.2337/diacare.9.3.244

96. Papakonstantinou E, Triantafillidou D, Panagiotakos D, Iraklianou S, Berdanier C, Zampelas A. A high protein low fat meal does not influence glucose and insulin responses in obese individuals with or without type 2 diabetes. J Hum Nutr Diet (2010) 23(2):183–9. doi:10.1111/j.1365-277X. 2009.01020.x

97. Gill JM, Al-Mamari A, Ferrell WR, Cleland SJ, Packard CJ, Sattar N, et al.Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men. J Am Coll Cardiol (2004) 44(12):2375–82. doi:10.1016/j.jacc.2004.09.035

98. Padilla J, Harris RA, Fly AD, Rink LD, Wallace JP. The effect of acute exercise on endothelial function following a high-fat meal. Eur J Appl Physiol (2006) 98(3):256–62. doi:10.1007/s00421-006-0272-z

99. Tyldum GA, Schjerve IE, Tjonna AE, Kirkeby-Garstad I, Stolen TO, Richardson RS, et al. Endothelial dysfunction induced by post-prandial lipemia: complete protection afforded by high-intensity aerobic interval exercise. J Am Coll Cardiol (2009) 53(2):200–6. doi:10.1016/j.jacc.2008.09.033

100. Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction testing and clinical relevance. Circulation (2007) 115(10):1285–95.


101. Inaba Y, Chen JA, Bergmann SR. Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis.Int J Cardiovasc Imaging (2010) 26(6):631–40. doi:10.1007/s10554-010-9616-1

102. O’Keefe JH, Bell DS. Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol (2007) 100(5):899–904. doi:10.1016/j.amjcard.2007.03.107

103. Wei-Chuan T, Yi-Heng L, Chih-Chan L, Ting-Hsing C, Jyh-Hong C. Effects of oxidative stress on endothelial function after a high-fat meal. Clin Sci (2004) 106(3):315–9. doi:10.1042/CS20030227

104. Herieka M, Erridge C. High-fat meal induced postprandial inflammation. Mol Nutr Food Res (2014) 58(1):136–46. doi:10.1002/mnfr.201300104

105. Ceriello A, Taboga C, Tonutti L, Quagliaro L, Piconi L, Bais B, et al. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation. Circulation (2002) 106(10):1211–8. doi:10.1161/01. CIR.0000027569.76671.A8

106. Steer P, Sarabi DM, Karlström B, Samar B, Berne C, Vessby B, et al. The effect of a mixed meal on endothelium-dependent vasodilation is dependent on fat content in healthy humans. Clin Sci (2003) 105(1):81–7. doi:10.1042/ CS20020327

107. Esser D, Oosterink E, Op’t Roodt J, Henry RM, Stehouwer CD, Müller M, et al. Vascular and inflammatory high fat meal responses in young healthy men; a discriminative role of IL-8 observed in a randomized trial. PLoS One (2013) 8(2):e53474. doi:10.1371/journal.pone.0053474

108. Tjonna AE, Rognmo O, Bye A, Stolen TO, Wisloff U. Time course of endothelial adaptation after acute and chronic exercise in patients with metabolic syndrome. J Strength Cond Res (2011) 25(9):2552–8. doi:10.1519/JSC.0b013e3181fb4809

109. Ross R. Does exercise without weight loss improve insulin sensitivity? Diabetes Care (2003) 26(3):944–5. doi:10.2337/diacare.26.3.944

110. Uusitupa M, Lindi V, Louheranta A, Salopuro T, Lindström J, Tuomilehto J. Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance. Diabetes (2003) 52(10):2532–8. doi:10.2337/diabetes.52.10.2532

111. Giannopoulou I, Ploutz-Snyder L, Carhart R, Weinstock R, Fernhall B, Goulopoulou S, et al. Exercise is required for visceral fat loss in postmenopausal women with type 2 diabetes. J Clin Endocrinol Metab (2005) 90(3):1511–8. doi:10.1210/jc.2004-1782.

112. Okura T, Nakata Y, Lee D, Ohkawara K, Tanaka K. Effects of aerobic exercise and obesity phenotype on abdominal fat reduction in response to weight loss. Int J Obes (2005) 29(10):1259–66. doi:10.1038/sj.ijo.0803013

113. Ballor DL, Katch V, Becque M, Marks C. Resistance weight training during caloric restriction enhances lean body weight maintenance. Am J Clin Nutr (1988) 47(1):19–25.

114. Foster-Schubert KE, Alfano CM, Duggan CR, Xiao L, Campbell KL, Kong A, et al. Effect of diet and exercise, alone or combined, on weight and body composition in overweight-to-obese postmenopausal women. Obesity (2012) 20(8):1628–38. doi:10.1038/oby.2011.76

115. Anton SD, Karabetian C, Naugle K, Buford TW. Obesity and diabetes as accelerators of functional decline: can lifestyle interventions maintain functional status in high risk older adults? Exp Gerontol (2013) 48(9):888–97. doi:10.1016/j.exger.2013.06.007

116. Park SW, Goodpaster BH, Lee JS, Kuller LH, Boudreau R, De Rekeneire N, et al. Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care (2009) 32(11):1993–7. doi:10.2337/dc09-0264

117. Fukushima Y, Kurose S, Shinno H, Cao Thu H, Takao N, Tsutsumi H, et al. Importance of lean muscle maintenance to improve insulin resistance by body weight reduction in female patients with obesity. Diabetes Metab J (2016) 40(2):147–53. doi:10.4093/dmj.2016.40.2.147

118. Robinson MM, Dasari S, Konopka AR, Johnson ML, Manjunatha S, Esponda RR, et al. Enhanced protein translation underlies improved metabolic and physical adaptations to different exercise training modes in young and old humans. Cell Metab (2017) 25(3):581–92. doi:10.1016/j.cmet.2017.02.009

119. Kreider RB, Rasmussen C, Kerksick CM, Wilborn C, Taylor L IV, Campbell B, et al. A carbohydrate-restricted diet during resistance training promotes more favorable changes in body composition and markers of health in obese women with and without insulin resistance. Phys Sportsmed (2011) 39(2):27–40. doi:10.3810/psm.2011.05.1893

120. Cartee GD, Young DA, Sleeper MD, Zierath J, Wallberg-Henriksson H, Holloszy J. Prolonged increase in insulin-stimulated glucose transport in muscle after exercise. Am J Physiol Endocrinol Metab (1989) 256(4):E494–9.

121. Hawley JA, Burke LM, Phillips SM, Spriet LL. Nutritional modulation of training-induced skeletal muscle adaptations. J Appl Physiol (2011) 110(3):834–45. doi:10.1152/japplphysiol.00949.2010

122. Leal-Cerro A, Gippini A, Amaya M, Lage M, Mato J, Dieguez C, et al. Mechanisms underlying the neuroendocrine response to physical exercise. J Endocrinol Invest (2003) 26(9):879–85. doi:10.1007/BF03345239

123. Pilegaard H, Osada T, Andersen LT, Helge JW, Saltin B, Neufer PD. Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. Metabolism (2005) 54(8):1048–55. doi:10.1016/j.metabol.2005.03.008

124. Yeo WK, Paton CD, Garnham AP, Burke LM, Carey AL, Hawley JA. Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens. J Appl Physiol (2008) 105(5):1462–70. doi:10.1152/japplphysiol.90882.2008

125. McBride A, Ghilagaber S, Nikolaev A, Hardie DG. The glycogen-binding domain on the AMPK β subunit allows the kinase to act as a glycogen sensor. Cell Metab (2009) 9(1):23–34. doi:10.1016/j.cmet.2008.11.008

126. Richter EA, Derave W, Wojtaszewski JF. Glucose, exercise and insulin: emerging concepts. J Physiol (2001) 535(2):313–22. doi:10.1111/j.1469- 7793.2001.t01-2-00313.x

127. Pilegaard H, Keller C, Steensberg A, Wulff Helge J, Klarlund Pedersen B, Saltin B, et al. Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes. J Physiol (2002) 541(1):261–71. doi:10.1113/jphysiol.2002.016832

128. Van Proeyen K, Szlufcik K, Nielens H, Ramaekers M, Hespel P. Beneficial metabolic adaptations due to endurance exercise training in the fasted state. J Appl Physiol (2011) 110(1):236–45. doi:10.1152/japplphysiol.00907. 2010

129. Hansen D, De Strijcker D, Calders P. Impact of endurance exercise training in the fasted state on muscle biochemistry and metabolism in healthy subjects: can these effects be of particular clinical benefit to type 2 diabetes mellitus and insulin-resistant patients? Sports Med (2017) 47(3):415–28. doi:10.1007/s40279-016-0594-x

130. Newsom SA, Schenk S, Thomas KM, Harber MP, Knuth ND, Goldenberg N, et al. Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity. J Appl Physiol (2010) 108(3):554–60. doi:10.1152/japplphysiol.01106.2009

131. Cochran AJ, Little JP, Tarnopolsky MA, Gibala MJ. Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of high-intensity interval exercise in humans. J Appl Physiol (2010) 108(3):628–36. doi:10.1152/japplphysiol.00659.2009

132. Bartlett JD, Louhelainen J, Iqbal Z, Cochran AJ, Gibala MJ, Gregson W, et al. Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis. Am J Physiol Regul Integr Comp Physiol (2013) 304(6):R450–8. doi:10.1152/ajpregu. 00498.2012

133. Sartor F, de Morree HM, Matschke V, Marcora SM, Milousis A, Thom JM, et al. High-intensity exercise and carbohydrate-reduced energy-restricted diet in obese individuals. Eur J Appl Physiol (2010) 110(5):893–903. doi:10.1007/s00421-010-1571


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