Una puesta al día en profundidad | 27 JUN 16

Fisiopatología y tratamiento de la sepsis

Revisión y puesta al día sobre un problema que, a pesar de las mejoras en el pronóstico, continúa siendo grave y muchas veces letal
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Autor/a: Gotts JE, Matthay MA Fuente: BMJ 2016; 353: i1585 Sepsis: pathophysiology and clinical management
INDICE:  1. Página 1 | 2. Referencias
Referencias

    ↵Bone RC, Sprung CL, Sibbald WJ. Definitions for sepsis and organ failure. Crit Care Med1992;20:724-6. doi:10.1097/00003246-199206000-00002 pmid:1597021.

    MedlineWeb of Science

    ↵American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med1992;20:864-74. doi:10.1097/00003246-199206000-00025 pmid:1597042.

    CrossRefMedlineWeb of Science

    ↵Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA2016;315:801-10. doi:10.1001/jama.2016.0287. pmid:26903338.

    CrossRefMedline

    ↵Levy MM, Fink MP, Marshall JC, et al. SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med2003;31:1250-6. doi:10.1097/01.CCM.0000050454.01978.3B. pmid:12682500.

    CrossRefMedlineWeb of Science

    ↵Churpek MM, Zadravecz FJ, Winslow C, Howell MD, Edelson DP. Incidence and prognostic value of the systemic inflammatory response syndrome and organ dysfunctions in ward patients. Am J Respir Crit Care Med2015;192:958-64. doi:10.1164/rccm.201502-0275OC. pmid:26158402.

    CrossRefMedline

    ↵Vincent J-L, Opal SM, Marshall JC, Tracey KJ. Sepsis definitions: time for change. Lancet2013;381:774-5. doi:10.1016/S0140-6736(12)61815-7. pmid:23472921.

    CrossRefMedlineWeb of Science

    ↵Ulloa L, Tracey KJ. The “cytokine profile”: a code for sepsis. Trends Mol Med2005;11:56-63. doi:10.1016/j.molmed.2004.12.007. pmid:15694867.

    CrossRefMedlineWeb of Science

    ↵Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med2001;29:1303-10. doi:10.1097/00003246-200107000-00002 pmid:11445675.

    CrossRefMedlineWeb of Science

    ↵Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med2003;348:1546-54. doi:10.1056/NEJMoa022139. pmid:12700374.

    CrossRefMedlineWeb of Science

    ↵Brun-Buisson C, Meshaka P, Pinton P, Vallet B. EPISEPSIS Study Group. EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med2004;30:580-8. doi:10.1007/s00134-003-2136-x. pmid:14997295.

    CrossRefMedlineWeb of Science

    ↵van Gestel A, Bakker J, Veraart CP, van Hout BA. Prevalence and incidence of severe sepsis in Dutch intensive care units. Crit Care2004;8:R153-62. doi:10.1186/cc2858. pmid:15312213.

    CrossRefMedlineWeb of Science

    ↵Harrison DA, Welch CA, Eddleston JM. The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care2006;10:R42. doi:10.1186/cc4854. pmid:16542492.

    CrossRefMedline

    ↵Kaukonen K-M, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA2014;311:1308-16. doi:10.1001/jama.2014.2637. pmid:24638143.

    CrossRefMedlineWeb of Science

    ↵Sakr Y, Elia C, Mascia L, et al. The influence of gender on the epidemiology of and outcome from severe sepsis. Crit Care2013;17:R50. doi:10.1186/cc12570. pmid:23506971.

    CrossRefMedline

    ↵Wichmann MW, Inthorn D, Andress H-J, Schildberg FW. Incidence and mortality of severe sepsis in surgical intensive care patients: the influence of patient gender on disease process and outcome. Intensive Care Med2000;26:167-72. doi:10.1007/s001340050041. pmid:10784304.

    CrossRefMedlineWeb of Science

    ↵Adrie C, Azoulay E, Francais A, et al. OutcomeRea Study Group. Influence of gender on the outcome of severe sepsis: a reappraisal. Chest2007;132:1786-93. doi:10.1378/chest.07-0420. pmid:17890473.

    CrossRefMedline

    ↵Angele MK, Pratschke S, Hubbard WJ, Chaudry IH. Gender differences in sepsis: cardiovascular and immunological aspects. Virulence2014;5:12-9. doi:10.4161/viru.26982. pmid:24193307.

    CrossRefMedlineWeb of Science

    ↵Barnato AE, Alexander SL, Linde-Zwirble WT, Angus DC. Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics. Am J Respir Crit Care Med2008;177:279-84. doi:10.1164/rccm.200703-480OC. pmid:17975201.

    CrossRefMedlineWeb of Science

    ↵Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Occurrence and outcomes of sepsis: influence of race. Crit Care Med2007;35:763-8. doi:10.1097/01.CCM.0000256726.80998.BF. pmid:17255870.

    CrossRefMedlineWeb of Science

    ↵Mayr FB, Yende S, Linde-Zwirble WT, et al. Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA2010;303:2495-503. doi:10.1001/jama.2010.851. pmid:20571016.

    CrossRefMedline

    ↵Ferwerda B, Alonso S, Banahan K, et al. Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A2009;106:10272-7. doi:10.1073/pnas.0811273106. pmid:19509334.

    Abstract/FREE Full Text

    ↵Ferwerda B, McCall MBB, Alonso S, et al. TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci U S A2007;104:16645-50. doi:10.1073/pnas.0704828104. pmid:17925445.

    Abstract/FREE Full Text

    ↵Martin GSM, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med2006;34:15-21. doi:10.1097/01.CCM.0000194535.82812.BA. pmid:16374151.

    CrossRefMedlineWeb of Science

    ↵Lemay ACB, Anzueto A, Restrepo MIM, Mortensen EM. Predictors of long-term mortality after severe sepsis in the elderly. Am J Med Sci2014;347:282-8. doi:10.1097/MAJ.0b013e318295a147. pmid:23689053.

    CrossRefMedline

    ↵Brun-Buisson C, Doyon F, Carlet J, et al. French ICU Group for Severe Sepsis. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. JAMA1995;274:968-74. doi:10.1001/jama.1995.03530120060042. pmid:7674528.

    CrossRefMedlineWeb of Science

    ↵Annane D, Aegerter P, Jars-Guincestre MC, Guidet B. CUB-Réa Network. Current epidemiology of septic shock: the CUB-Réa Network. Am J Respir Crit Care Med2003;168:165-72. doi:10.1164/rccm.2201087. pmid:12851245.

    CrossRefMedlineWeb of Science

    ↵Beale R, Reinhart K, Brunkhorst FM, et al. PROGRESS Advisory Board. Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry. Infection2009;37:222-32. doi:10.1007/s15010-008-8203-z. pmid:19404580.

    CrossRefMedlineWeb of Science

    ↵Tolsma V, Schwebel C, Azoulay E, et al. Sepsis severe or septic shock: outcome according to immune status and immunodeficiency profile. Chest2014;146:1205-13. doi:10.1378/chest.13-2618. pmid:25033349.

    CrossRefMedline

    ↵Williams MD, Braun LA, Cooper LM, et al. Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care. Crit Care2004;8:R291-8. doi:10.1186/cc2893. pmid:15469571.

    CrossRefMedlineWeb of Science

    ↵Rosolem MM, Rabello LSCF, Lisboa T, et al. Critically ill patients with cancer and sepsis: clinical course and prognostic factors. J Crit Care2012;27:301-7. doi:10.1016/j.jcrc.2011.06.014. pmid:21855281.

    CrossRefMedline

    ↵Zuber B, Tran T-C, Aegerter P, et al. CUB-Réa Network. Impact of case volume on survival of septic shock in patients with malignancies. Crit Care Med2012;40:55-62. doi:10.1097/CCM.0b013e31822d74ba. pmid:21926606.

    CrossRefMedlineWeb of Science

    ↵Sørensen TIA, Nielsen GG, Andersen PK, Teasdale TW. Genetic and environmental influences on premature death in adult adoptees. N Engl J Med1988;318:727-32. doi:10.1056/NEJM198803243181202. pmid:3347221.

    CrossRefMedlineWeb of Science

    ↵Netea MG, van der Meer JWM. Immunodeficiency and genetic defects of pattern-recognition receptors. N Engl J Med2011;364:60-70. doi:10.1056/NEJMra1001976. pmid:21208109.

    CrossRefMedline

    ↵Meyer NJM. Finding a needle in the haystack: leveraging bioinformatics to identify a functional genetic risk factor for sepsis death. Crit Care Med2015;43:242-3. doi:10.1097/CCM.0000000000000664. pmid:25514715.

    Medline

    ↵Tang BM, Huang SJ, McLean AS. Genome-wide transcription profiling of human sepsis: a systematic review. Crit Care2010;14:R237. doi:10.1186/cc9392. pmid:21190579.

    CrossRefMedline

    ↵Clark MF, Baudouin SV. A systematic review of the quality of genetic association studies in human sepsis. Intensive Care Med2006;32:1706-12. doi:10.1007/s00134-006-0327-y. pmid:16957907.

    CrossRefMedlineWeb of Science

    ↵Agnese DM, Calvano JE, Hahm SJ, et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis2002;186:1522-5. doi:10.1086/344893. pmid:12404174.

    Abstract/FREE Full Text

    ↵Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med2002;162:1028-32. doi:10.1001/archinte.162.9.1028. pmid:11996613.

    CrossRefMedlineWeb of Science

    ↵Van der Graaf CA, Netea MG, Morré SA, et al. Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection. Eur Cytokine Netw2006;17:29-34.pmid:16613760.

    MedlineWeb of Science

    ↵Plantinga TS, Johnson MD, Scott WK, et al. Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. J Infect Dis2012;205:934-43. doi:10.1093/infdis/jir867. pmid:22301633.

    Abstract/FREE Full Text

    ↵Bochud P-Y, Chien JW, Marr KA, et al. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med2008;359:1766-77. doi:10.1056/NEJMoa0802629. pmid:18946062.

    CrossRefMedlineWeb of Science

    ↵Henckaerts L, Nielsen KR, Steffensen R, et al. Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med2009;37:192-201, e1-3. doi:10.1097/CCM.0b013e31819263d8. pmid:19050632.

    CrossRefMedlineWeb of Science

    ↵Nakada TA, Russell JAM, Boyd JHM, Thair SA, Walley KR. Identification of a nonsynonymous polymorphism in the SVEP1 gene associated with altered clinical outcomes in septic shock. Crit Care Med2015;43:101-8. doi:10.1097/CCM.0000000000000604. pmid:25188548.

    Medline

    ↵Rautanen A, Mills TC, Gordon AC, et al. ESICM/ECCRN GenOSept Investigators. Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med2015;3:53-60. doi:10.1016/S2213-2600(14)70290-5. pmid:25533491.

    CrossRefMedline

    ↵O’Brien JMJM Jr, , Lu B, Ali NA, et al. Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Crit Care Med2007;35:345-50. doi:10.1097/01.CCM.0000254340.91644.B2. pmid:17205003.

    CrossRefMedlineWeb of Science

    ↵Henriksen DP, Pottegård A, Laursen CB, et al. Risk factors for hospitalization due to community-acquired sepsis—a population-based case-control study. PLoS One2015;10:e0124838. doi:10.1371/journal.pone.0124838. pmid:25898024.

    CrossRefMedline

    ↵Calfee CSM, Matthay MA, Kangelaris KNM, et al. Cigarette smoke exposure and the acute respiratory distress syndrome. Crit Care Med2015;43:1790-7. doi:10.1097/CCM.0000000000001089. pmid:26010690.

    CrossRefMedline

    ↵Calfee CS, Matthay MA, Eisner MD, et al. Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med2011;183:1660-5. doi:10.1164/rccm.201011-1802OC. pmid:21471091.

    CrossRefMedlineWeb of Science

    ↵Wang HE, Shapiro NI, Griffin R, Safford MM, Judd S, Howard G. Chronic medical conditions and risk of sepsis. PLoS One2012;7:e48307. doi:10.1371/journal.pone.0048307. pmid:23118977.

    CrossRefMedline

    ↵Arcavi L, Benowitz NL. Cigarette smoking and infection. Arch Intern Med2004;164:2206-16. doi:10.1001/archinte.164.20.2206. pmid:15534156.

    CrossRefMedlineWeb of Science

    ↵Garcia-Vidal C, Ardanuy C, Tubau F, et al. Pneumococcal pneumonia presenting with septic shock: host- and pathogen-related factors and outcomes. Thorax2010;65:77-81. doi:10.1136/thx.2009.123612. pmid:19996337.

    Abstract/FREE Full Text

    ↵Bello S, Menéndez R, Torres A, et al. Tobacco smoking increases the risk for death from pneumococcal pneumonia. Chest2014;146:1029-37. doi:10.1378/chest.13-2853. pmid:24811098.

    CrossRefMedline

    ↵Turan A, Mascha EJ, Roberman D, et al. Smoking and perioperative outcomes. Anesthesiology2011;114:837-46. doi:10.1097/ALN.0b013e318210f560. pmid:21372682.

    CrossRefMedlineWeb of Science

    ↵Blair LJ, Huntington CR, Cox TC, et al Risk factors for postoperative sepsis in laparoscopic gastric bypass. Surg Endosc2015; published online 1 July. doi:10.1007/s00464-015-4349-9.

    ↵de Haan K, Groeneveld AB, de Geus HR, Egal M, Struijs A. Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis. Crit Care2014;18:660. doi:10.1186/s13054-014-0660-4. pmid:25475621.

    CrossRefMedline

    ↵Bjelakovic G, Gluud LL, Nikolova D, et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev2014;1:CD007470. doi:10.1002/14651858.CD007470.pub3. pmid:24414552.

    Medline

    ↵Georges S, Lepoutre A, Dabernat H, Levy-Bruhl D. Impact of Haemophilus influenzae type b vaccination on the incidence of invasive Haemophilus influenzae disease in France, 15 years after its introduction. Epidemiol Infect2013;141:1787-96. doi:10.1017/S0950268813000083. pmid:23425638.

    CrossRefWeb of Science

    ↵Vincent J-L, Rello J, Marshall J, et al. EPIC II Group of Investigators. International study of the prevalence and outcomes of infection in intensive care units. JAMA2009;302:2323-9. doi:10.1001/jama.2009.1754. pmid:19952319.

    CrossRefMedlineWeb of Science

    ↵Obaro SK, Monteil MA, Henderson DC. The pneumococcal problem. BMJ1996;312:1521-5. doi:10.1136/bmj.312.7045.1521 pmid:8646147.

    Abstract/FREE Full Text

    ↵Kett DH, Azoulay E, Echeverria PM, Vincent JL. Extended Prevalence of Infection in ICU Study (EPIC II) Group of Investigators. Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med2011;39:665-70. doi:10.1097/CCM.0b013e318206c1ca. pmid:21169817.

    CrossRefMedlineWeb of Science

    ↵Hanberger H, Walther S, Leone M, et al. EPIC II Group of Investigators. Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study. Int J Antimicrob Agents2011;38:331-5. doi:10.1016/j.ijantimicag.2011.05.013. pmid:21798720.

    CrossRefMedline

    ↵Hanberger H, Antonelli M, Holmbom M, et al. EPIC II Group of Investigators. Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels. BMC Infect Dis2014;14:513. doi:10.1186/1471-2334-14-513. pmid:25245620.

    CrossRefMedline

    ↵De Waele J, Lipman J, Sakr Y, et al. EPIC II Investigators. Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome. BMC Infect Dis2014;14:420. doi:10.1186/1471-2334-14-420. pmid:25074742.

    CrossRefMedline

    ↵Gustot T, Felleiter P, Pickkers P, et al. EPIC II Group of Investigators. Impact of infection on the prognosis of critically ill cirrhotic patients: results from a large worldwide study. Liver Int2014;34:1496-503. doi:10.1111/liv.12520. pmid:24606193.

    CrossRefMedline

    ↵Weiss SL, Fitzgerald JC, Pappachan J, et al. Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med2015;191:1147-57. doi:10.1164/rccm.201412-2323OC. pmid:25734408.

    CrossRefMedline

    ↵Hartman ME, Linde-Zwirble WT, Angus DC, Watson RS. Trends in the epidemiology of pediatric severe sepsis. Pediatr Crit Care Med2013;14:686-93. doi:10.1097/PCC.0b013e3182917fad. pmid:23897242.

    CrossRefMedline

    ↵Rabuel C, Mebazaa A. Septic shock: a heart story since the 1960s. Intensive Care Med2006;32:799-807. doi:10.1007/s00134-006-0142-5. pmid:16570145.

    CrossRefMedlineWeb of Science

    ↵Kimchi A, Ellrodt AG, Berman DS, Riedinger MS, Swan HJ, Murata GH. Right ventricular performance in septic shock: a combined radionuclide and hemodynamic study. J Am Coll Cardiol1984;4:945-51. doi:10.1016/S0735-1097(84)80055-8 pmid:6491086.

    CrossRefMedlineWeb of Science

    ↵Parker MM, Shelhamer JH, Bacharach SL, et al. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med1984;100:483-90. doi:10.7326/0003-4819-100-4-483 pmid:6703540.

    CrossRefMedlineWeb of Science

    ↵Shapiro NI, Howell MD, Talmor D, et al. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med2005;45:524-8. doi:10.1016/j.annemergmed.2004.12.006. pmid:15855951.

    CrossRefMedlineWeb of Science

    ↵Kraut JA, Madias NE. Lactic acidosis. N Engl J Med2014;371:2309-19. doi:10.1056/NEJMra1309483. pmid:25494270.

    CrossRefMedline

    ↵Hayes MA, Timmins AC, Yau EH, Palazzo M, Hinds CJ, Watson D. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med1994;330:1717-22. doi:10.1056/NEJM199406163302404. pmid:7993413.

    CrossRefMedlineWeb of Science

    ↵Rivers E, Nguyen B, Havstad S, et al. Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med2001;345:1368-77. doi:10.1056/NEJMoa010307. pmid:11794169.

    CrossRefMedlineWeb of Science

    ↵Garcia-Alvarez M, Marik P, Bellomo R. Sepsis-associated hyperlactatemia. Crit Care2014;18:503. doi:10.1186/s13054-014-0503-3. pmid:25394679.

    CrossRefMedline

    ↵Ronco JJ, Fenwick JC, Tweeddale MG, et al. Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and nonseptic humans. JAMA1993;270:1724-30. doi:10.1001/jama.1993.03510140084034 pmid:8411504.

    CrossRefMedlineWeb of Science

    ↵Wolinsky H. A proposal linking clearance of circulating lipoproteins to tissue metabolic activity as a basis for understanding atherogenesis. Circ Res1980;47:301-11. doi:10.1161/01.RES.47.3.301 pmid:6996862.

    FREE Full Text

    ↵Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood2003;101:3765-77. doi:10.1182/blood-2002-06-1887. pmid:12543869.

    Abstract/FREE Full Text

    ↵Koh IHJ, Menchaca-Diaz JL, Koh TH, et al. Microcirculatory evaluation in sepsis: a difficult task. Shock2010;34(Suppl 1):27-33. doi:10.1097/SHK.0b013e3181e7e80c. pmid:20523273.

    CrossRefMedline

    ↵De Backer D, Ortiz JA, Salgado D. Coupling microcirculation to systemic hemodynamics. Curr Opin Crit Care2010;16:250-4. doi:10.1097/MCC.0b013e3283383621. pmid:20179590.

    CrossRefMedlineWeb of Science

    ↵Levi M. Pathogenesis and treatment of disseminated intravascular coagulation in the septic patient. J Crit Care2001;16:167-77. doi:10.1053/jcrc.2001.30666. pmid:11815902.

    CrossRefMedlineWeb of Science

    ↵Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest2012;122:2731-40. doi:10.1172/JCI60331. pmid:22850883.

    CrossRefMedlineWeb of Science

    ↵Deutschman CS, Tracey KJ. Sepsis: current dogma and new perspectives. Immunity2014;40:463-75. doi:10.1016/j.immuni.2014.04.001. pmid:24745331.

    CrossRefMedline

    ↵Fink MP. Intestinal epithelial hyperpermeability: update on the pathogenesis of gut mucosal barrier dysfunction in critical illness. Curr Opin Crit Care2003;9:143-51. doi:10.1097/00075198-200304000-00011 pmid:12657978.

    CrossRefMedline

    ↵Schmid-Schönbein GW, Chang M. The autodigestion hypothesis for shock and multi-organ failure. Ann Biomed2014;42:405-14. doi:10.1007/s10439-013-0891-6. pmid:23989761.

    CrossRef

    ↵Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA. Post-injury multiple organ failure: the role of the gut. Shock2001;15:1-10. doi:10.1097/00024382-200115010-00001 pmid:11198350.

    MedlineWeb of Science

    ↵Doig CJ, Sutherland LR, Sandham JD, Fick GH, Verhoef M, Meddings JB. Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med1998;158:444-51. doi:10.1164/ajrccm.158.2.9710092. pmid:9700119.

    CrossRefMedlineWeb of Science

    ↵Walley KR, Francis GA, Opal SM, et al. The central role of proprotein convertase subtilisin/kexin type 9 in septic pathogen lipid transport and clearance. Am J Respir Crit Care Med2015;192:1275-86. doi:10.1164/rccm.201505-0876CI. pmid:26252194.

    CrossRefMedline

    ↵Alobaidi R, Basu RK, Goldstein SL, Bagshaw SM. Sepsis-associated acute kidney injury. Semin Nephrol2015;35:2-11. doi:10.1016/j.semnephrol.2015.01.002. pmid:25795495.

    CrossRefMedline

    ↵Wan L, Bagshaw SM, Langenberg C, Saotome T, May C, Bellomo R. Pathophysiology of septic acute kidney injury: what do we really know?Crit Care Med2008;36(Suppl):S198-203. doi:10.1097/CCM.0b013e318168ccd5. pmid:18382194.

    CrossRefMedlineWeb of Science

    ↵Ishikawa K, May CN, Gobe G, Langenberg C, Bellomo R. Pathophysiology of septic acute kidney injury: a different view of tubular injury. Contrib Nephrol2010;165:18-27. doi:10.1159/000313740. pmid:20427951.

    CrossRefMedlineWeb of Science

    ↵Takasu O, Gaut JP, Watanabe E, et al. Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med2013;187:509-17. doi:10.1164/rccm.201211-1983OC. pmid:23348975.

    CrossRefMedlineWeb of Science

    ↵Prowle JR, Bellomo R. Sepsis-associated acute kidney injury: macrohemodynamic and microhemodynamic alterations in the renal circulation. Semin Nephrol2015;35:64-74. doi:10.1016/j.semnephrol.2015.01.007. pmid:25795500.

    CrossRefMedline

    ↵Tracey KJ. Reflex control of immunity. Nat Rev Immunol2009;9:418-28. doi:10.1038/nri2566. pmid:19461672.

    CrossRefMedlineWeb of Science

    ↵Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature2000;405:458-62. doi:10.1038/35013070. pmid:10839541.

    CrossRefMedlineWeb of Science

    ↵Ortiz-Pomales YT, Krzyzaniak M, Coimbra R, Baird A, Eliceiri BP. Vagus nerve stimulation blocks vascular permeability following burn in both local and distal sites. Burns2013;39:68-75. doi:10.1016/j.burns.2012.04.004. pmid:22694873.

    CrossRefMedline

    ↵Van Westerloo DJ, Giebelen IA, Florquin S, et al. The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology2006;130:1822-30. doi:10.1053/j.gastro.2006.02.022. pmid:16697744.

    CrossRefMedlineWeb of Science

    ↵Bernik TR, Friedman SG, Ochani M, et al. Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J Vasc Surg2002;36:1231-6. doi:10.1067/mva.2002.129643. pmid:12469056.

    CrossRefMedlineWeb of Science

    ↵Ziaja M. Septic encephalopathy. Curr Neurol Neurosci Rep2013;13:383. doi:10.1007/s11910-013-0383-y. pmid:23954971.

    CrossRefMedline

    ↵Ely EW, Shintani A, Truman B, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA2004;291:1753-62. doi:10.1001/jama.291.14.1753. pmid:15082703.

    CrossRefMedlineWeb of Science

    ↵Pandharipande PP, Girard TD, Jackson JC, et al. BRAIN-ICU Study Investigators. Long-term cognitive impairment after critical illness. N Engl J Med2013;369:1306-16. doi:10.1056/NEJMoa1301372. pmid:24088092.

    CrossRefMedlineWeb of Science

    ↵Iacobone E, Bailly-Salin J, Polito A, Friedman D, Stevens RD, Sharshar T. Sepsis-associated encephalopathy and its differential diagnosis. Crit Care Med2009;37(Suppl):S331-6. doi:10.1097/CCM.0b013e3181b6ed58. pmid:20046118.

    CrossRefMedline

    ↵Sharshar T, Carlier R, Bernard F, et al. Brain lesions in septic shock: a magnetic resonance imaging study. Intensive Care Med2007;33:798-806. doi:10.1007/s00134-007-0598-y. pmid:17377766.

    CrossRefMedline

    ↵Schramm P, Klein KU, Falkenberg L, et al. Impaired cerebrovascular autoregulation in patients with severe sepsis and sepsis-associated delirium. Crit Care2012;16:R181. doi:10.1186/cc11665. pmid:23036135.

    CrossRefMedline

    ↵Sharshar T, Annane D, de la Grandmaison GL, Brouland JP, Hopkinson NS, Françoise G. The neuropathology of septic shock. Brain Pathol2004;14:21-33. doi:10.1111/j.1750-3639.2004.tb00494.x pmid:14997934.

    CrossRefMedlineWeb of Science

    ↵Boomer JS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA2011;306:2594-605. doi:10.1001/jama.2011.1829. pmid:22187279.

    CrossRefMedlineWeb of Science

    ↵Hotchkiss RS, Tinsley KW, Swanson PE, et al. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol2001;166:6952-63. doi:10.4049/jimmunol.166.11.6952 pmid:11359857.

    Abstract/FREE Full Text

    ↵Cabrera-Perez J, Condotta SA, Badovinac VP, Griffith TS. Impact of sepsis on CD4 T cell immunity. J Leukoc Biol2014;96:767-77. doi:10.1189/jlb.5MR0114-067R. pmid:24791959.

    Abstract/FREE Full Text

    ↵Walton AH, Muenzer JT, Rasche D, et al. Reactivation of multiple viruses in patients with sepsis. PLoS One2014;9:e98819. doi:10.1371/journal.pone.0098819. pmid:24919177.

    CrossRefMedline

    ↵Drewry AM, Samra N, Skrupky LP, Fuller BM, Compton SM, Hotchkiss RS. Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock2014;42:383-91. doi:10.1097/SHK.0000000000000234. pmid:25051284.

    CrossRefMedline

    ↵Otto GP, Sossdorf M, Claus RA, et al. The late phase of sepsis is characterized by an increased microbiological burden and death rate. Crit Care2011;15:R183. doi:10.1186/cc10332. pmid:21798063.

    CrossRefMedline

    ↵Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med2013;369:2126-36. doi:10.1056/NEJMra1208707. pmid:24283226.

    CrossRefMedlineWeb of Science

    ↵Reade MC, Finfer S. Sedation and delirium in the intensive care unit. N Engl J Med2014;370:444-54. doi:10.1056/NEJMra1208705. pmid:24476433.

    CrossRefMedline

    ↵Nelson JE, Cox CE, Hope AA, Carson SS. Chronic critical illness. Am J Respir Crit Care Med2010;182:446-54. doi:10.1164/rccm.201002-0210CI. pmid:20448093.

    CrossRefMedlineWeb of Science

    ↵Moine P, Abraham E. Immunomodulation and sepsis: impact of the pathogen. Shock2004;22:297-308. doi:10.1097/01.shk.0000140663.80530.73 pmid:15377883.

    CrossRefMedline

    ↵Tracey KJ, Beutler B, Lowry SF, et al. Shock and tissue injury induced by recombinant human cachectin. Science1986;234:470-4. doi:10.1126/science.3764421 pmid:3764421.

    Abstract/FREE Full Text

    ↵Dunn DL. Role of endotoxin and host cytokines in septic shock. Chest1991;100(Suppl):164S-8S. doi:10.1378/chest.100.3_Supplement.164S pmid:1884642.

    Medline

    ↵Tracey KJ, Fong Y, Hesse DG, et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature1987;330:662-4. doi:10.1038/330662a0. pmid:3317066.

    CrossRefMedlineWeb of Science

    ↵Fisher CJ Jr, , Agosti JM, Opal SM, et al. The Soluble TNF Receptor Sepsis Study Group. Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. N Engl J Med1996;334:1697-702. doi:10.1056/NEJM199606273342603. pmid:8637514.

    CrossRefMedlineWeb of Science

    ↵Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell2010;140:805-20. doi:10.1016/j.cell.2010.01.022. pmid:20303872.

    CrossRefMedlineWeb of Science

    ↵Schulte W, Bernhagen J, Bucala R. Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view. Mediators Inflamm2013;2013:165974. doi:10.1155/2013/165974. pmid:23853427.

    CrossRefMedline

    ↵Schroder K, Tschopp J. The inflammasomes. Cell2010;140:821-32. doi:10.1016/j.cell.2010.01.040. pmid:20303873.

    CrossRefMedlineWeb of Science

    ↵Martinod K, Wagner DD. Thrombosis: tangled up in NETs. Blood2014;123:2768-76. doi:10.1182/blood-2013-10-463646. pmid:24366358.

    Abstract/FREE Full Text

    ↵Meziani F, Delabranche X, Asfar P, Toti F. Bench-to-bedside review: circulating microparticles--a new player in sepsis?Crit Care2010;14:236. doi:10.1186/cc9231. pmid:21067540.

    CrossRefMedline

    ↵Engelmann B, Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol2013;13:34-45. doi:10.1038/nri3345. pmid:23222502.

    CrossRefMedline

    ↵Ward PA, Gao H. Sepsis, complement and the dysregulated inflammatory response. J Cell Mol Med2009;13:4154-60. doi:10.1111/j.1582-4934.2009.00893.x. pmid:19725914.

    CrossRefMedline

    ↵Brealey D, Brand M, Hargreaves I, et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet2002;360:219-23. doi:10.1016/S0140-6736(02)09459-X. pmid:12133657.

    CrossRefMedlineWeb of Science

    ↵Singer M. The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence2014;5:66-72. doi:10.4161/viru.26907. pmid:24185508.

    CrossRefMedline

    ↵Puthucheary ZA, Rawal J, McPhail M, et al. Acute skeletal muscle wasting in critical illness. JAMA2013;310:1591-600. doi:10.1001/jama.2013.278481. pmid:24108501.

    CrossRefMedlineWeb of Science

    ↵Hartl WH, Jauch K-W. Metabolic self-destruction in critically ill patients: origins, mechanisms and therapeutic principles. Nutrition2014;30:261-7. doi:10.1016/j.nut.2013.07.019. pmid:24369911.

    CrossRefMedline

    ↵Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol2013;13:722-37. doi:10.1038/nri3532. pmid:24064518.

    CrossRefMedline

    ↵Fullerton JN, O’Brien AJ, Gilroy DW. Pathways mediating resolution of inflammation: when enough is too much. J Pathol2013;231:8-20. doi:10.1002/path.4232. pmid:23794437.

    CrossRefMedline

    ↵Levy BD, Serhan CN. Resolution of acute inflammation in the lung. Annu Rev Physiol2014;76:467-92. doi:10.1146/annurev-physiol-021113-170408. pmid:24313723.

    CrossRefMedlineWeb of Science

    ↵Talan DA, Guterman JJ, Overturf GD, Singer C, Hoffman JR, Lambert B. Analysis of emergency department management of suspected bacterial meningitis. Ann Emerg Med1989;18:856-62. doi:10.1016/S0196-0644(89)80213-6 pmid:2757283.

    CrossRefMedlineWeb of Science

    ↵Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med2006;34:1589-96. doi:10.1097/01.CCM.0000217961.75225.E9. pmid:16625125.

    CrossRefMedlineWeb of Science

    ↵Ferrer R, Martin-Loeches I, Phillips G, et al. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med2014;42:1749-55. doi:10.1097/CCM.0000000000000330. pmid:24717459.

    CrossRefMedlineWeb of Science

    ↵Sterling SA, Miller WR, Pryor J, Puskarich MA, Jones AE. The impact of timing of antibiotics on outcomes in severe sepsis and septic shock: a systematic review and meta-analysis. Crit Care Med2015;43:1907-15. doi:10.1097/CCM.0000000000001142. pmid:26121073.

    CrossRefMedline

    ↵Sivapalan P, Stæhr Jensen J-U. Timing of therapy in sepsis: are early antibiotics important for prognosis?Crit Care Med2015;43:2030-1. doi:10.1097/CCM.0000000000001179. pmid:26274712.

    CrossRefMedline

    ↵Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med2013;41:580-637. doi:10.1097/CCM.0b013e31827e83af. pmid:23353941.

    CrossRefMedlineWeb of Science

    ↵Ronco JJ, Fenwick JC, Tweeddale MG. Does increasing oxygen delivery improve outcome in the critically ill? No. Crit Care Clin1996;12:645-59. doi:10.1016/S0749-0704(05)70268-2 pmid:8839596.

    CrossRefMedline

    ↵Gattinoni L, Brazzi L, Pelosi P, et al. A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med1995;333:1025-32. doi:10.1056/NEJM199510193331601. pmid:7675044.

    CrossRefMedlineWeb of Science

    ↵Maitland K, Kiguli S, Opoka RO, et al. FEAST Trial Group. Mortality after fluid bolus in African children with severe infection. N Engl J Med2011;364:2483-95. doi:10.1056/NEJMoa1101549. pmid:21615299.

    CrossRefMedlineWeb of Science

    ↵Perner A, Haase N, Guttormsen AB, et al. 6S Trial Group Scandinavian Critical Care Trials Group. Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med2012;367:124-34. doi:10.1056/NEJMoa1204242. pmid:22738085.

    CrossRefMedlineWeb of Science

    ↵Yealy DM, Kellum JA, Huang DT, et al. ProCESS Investigators. A randomized trial of protocol-based care for early septic shock. N Engl J Med2014;370:1683-93. doi:10.1056/NEJMoa1401602. pmid:24635773.

    CrossRefMedlineWeb of Science

    ↵Peake SL, Delaney A, Bailey M, et al. ARISE Investigators ANZICS Clinical Trials Group. Goal-directed resuscitation for patients with early septic shock. N Engl J Med2014;371:1496-506. doi:10.1056/NEJMoa1404380. pmid:25272316.

    CrossRefMedlineWeb of Science

    ↵Caironi P, Tognoni G, Masson S, et al. ALBIOS Study Investigators. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med2014;370:1412-21. doi:10.1056/NEJMoa1305727. pmid:24635772.

    CrossRefMedlineWeb of Science

    ↵Asfar P, Meziani F, Hamel J-F, et al. SEPSISPAM Investigators. High versus low blood-pressure target in patients with septic shock. N Engl J Med2014;370:1583-93. doi:10.1056/NEJMoa1312173. pmid:24635770.

    CrossRefMedlineWeb of Science

    ↵Holst LB, Haase N, Wetterslev J, et al. TRISS Trial Group Scandinavian Critical Care Trials Group. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med2014;371:1381-91. doi:10.1056/NEJMoa1406617. pmid:25270275.

    CrossRefMedlineWeb of Science

    ↵Mouncey PR, Osborn TM, Power GS, et al. ProMISe Trial Investigators. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med2015;372:1301-11. doi:10.1056/NEJMoa1500896. pmid:25776532.

    CrossRefMedline

    ↵Young P, Bailey M, Beasley R, et al. SPLIT Investigators ANZICS CTG. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial. JAMA2015;314:1701-10. doi:10.1001/jama.2015.12334. pmid:26444692.

    CrossRefMedline

    ↵Levy MM, Dellinger RP, Townsend SR, et al. Surviving Sepsis Campaign. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med2010;38:367-74. doi:10.1097/CCM.0b013e3181cb0cdc. pmid:20035219.

    CrossRefMedlineWeb of Science

    ↵Patel A, Laffan MA, Waheed U, Brett SJ. Randomised trials of human albumin for adults with sepsis: systematic review and meta-analysis with trial sequential analysis of all-cause mortality. BMJ2014;349:g4561. doi:10.1136/bmj.g4561 pmid:25099709.

    Abstract/FREE Full Text

    ↵Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA2012;308:1566-72. doi:10.1001/jama.2012.13356. pmid:23073953.

    CrossRefMedlineWeb of Science

    ↵Greenfield N, Balk RA. Evaluating the adequacy of fluid resuscitation in patients with septic shock: controversies and future directions. Hosp Pract (1995)2012;40:147-57. doi:10.3810/hp.2012.04.980. pmid:22615089.

    CrossRef

    ↵Wiedemann HP, Wheeler AP, Bernard GR, et al. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med2006;354:2564-75. doi:10.1056/NEJMoa062200. pmid:16714767.

    CrossRefMedlineWeb of Science

    ↵Vincent J-L, Sakr Y, Sprung CL, et al. Sepsis Occurrence in Acutely Ill Patients Investigators. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med2006;34:344-53. doi:10.1097/01.CCM.0000194725.48928.3A pmid:16424713.

    CrossRefMedlineWeb of Science

    ↵de Oliveira FSV, Freitas FGR, Ferreira EM, et al. Positive fluid balance as a prognostic factor for mortality and acute kidney injury in severe sepsis and septic shock. J Crit Care2015;30:97-101. doi:10.1016/j.jcrc.2014.09.002. pmid:25269788.

    CrossRefMedline

    ↵Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Emergency Medicine Shock Research Network (EMShockNet) Investigators. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA2010;303:739-46. doi:10.1001/jama.2010.158. pmid:20179283.

    CrossRefMedlineWeb of Science

    ↵Funk DJ, Jacobsohn E, Kumar A. Role of the venous return in critical illness and shock: part II-shock and mechanical ventilation. Crit Care Med2013;41:573-9. doi:10.1097/CCM.0b013e31827bfc25. pmid:23263572.

    CrossRefMedlineWeb of Science

    ↵Persichini R, Silva S, Teboul J-L, et al. Effects of norepinephrine on mean systemic pressure and venous return in human septic shock. Crit Care Med2012;40:3146-53. doi:10.1097/CCM.0b013e318260c6c3. pmid:22926333.

    CrossRefMedline

    ↵Waechter J, Kumar A, Lapinsky SE, et al. Cooperative Antimicrobial Therapy of Septic Shock Database Research Group. Interaction between fluids and vasoactive agents on mortality in septic shock: a multicenter, observational study. Crit Care Med2014;42:2158-68. doi:10.1097/CCM.0000000000000520. pmid:25072761.

    CrossRefMedline

    ↵Havel C, Arrich J, Losert H, Gamper G, Müllner M, Herkner H. Vasopressors for hypotensive shock. Cochrane Database Syst Rev2011;5:CD003709. doi:10.1002/14651858.CD003709.pub3. pmid:21563137.

    Medline

    ↵De Backer D, Aldecoa C, Njimi H, Vincent JL. Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis. Crit Care Med2012;40:725-30. doi:10.1097/CCM.0b013e31823778ee. pmid:22036860.

    CrossRefMedlineWeb of Science

    ↵ The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med2000;342:1301-8. doi:10.1056/NEJM200005043421801. pmid:10793162.

    CrossRefMedlineWeb of Science

    ↵Eisner MD, Thompson T, Hudson LD, et al. Acute Respiratory Distress Syndrome Network. Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med2001;164:231-6. doi:10.1164/ajrccm.164.2.2011093. pmid:11463593.

    CrossRefMedlineWeb of Science

    ↵Kollef MH, Levy NT, Ahrens TS, Schaiff R, Prentice D, Sherman G. The use of continuous iv sedation is associated with prolongation of mechanical ventilation. Chest1998;114:541-8. doi:10.1378/chest.114.2.541 pmid:9726743.

    CrossRefMedlineWeb of Science

    ↵Shehabi Y, Bellomo R, Reade MC, et al. Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators ANZICS Clinical Trials Group. Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med2012;186:724-31. doi:10.1164/rccm.201203-0522OC. pmid:22859526.

    CrossRefMedlineWeb of Science

    ↵Kress JP, Pohlman AS, O’Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med2000;342:1471-7. doi:10.1056/NEJM200005183422002. pmid:10816184.

    CrossRefMedlineWeb of Science

    ↵Schweickert WD, Pohlman MC, Pohlman AS, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet2009;373:1874-82. doi:10.1016/S0140-6736(09)60658-9. pmid:19446324.

    CrossRefMedlineWeb of Science

    ↵Fernandez JF, Levine SM, Restrepo MI. Technologic advances in endotracheal tubes for prevention of ventilator-associated pneumonia. Chest2012;142:231-8. doi:10.1378/chest.11-2420. pmid:22796845.

    CrossRefMedlineWeb of Science

    ↵Shi Z, Xie H, Wang P, et al. Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev2013;8:CD008367. doi:10.1002/14651858.CD008367.pub2. pmid:23939759.

    Medline

    ↵Veenstra DL, Saint S, Saha S, Lumley T, Sullivan SD. Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection: a meta-analysis. JAMA1999;281:261-7. doi:10.1001/jama.281.3.261 pmid:9918482.

    CrossRefMedlineWeb of Science

    ↵Pronovost P, Needham D, Berenholtz S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med2006;355:2725-32. doi:10.1056/NEJMoa061115. pmid:17192537.

    CrossRefMedlineWeb of Science

    ↵Galiczewski JM. Interventions for the prevention of catheter associated urinary tract infections in intensive care units: an integrative review. Intensive Crit Care Nurs2016;32:1-11. doi:10.1016/j.iccn.2015.08.007. pmid:26604039.

    CrossRefMedline

    ↵Koretz RL, Avenell A, Lipman TO, Braunschweig CL, Milne AC. Does enteral nutrition affect clinical outcome? A systematic review of the randomized trials. Am J Gastroenterol2007;102:412-29, quiz 468. doi:10.1111/j.1572-0241.2006.01024.x. pmid:17311654.

    CrossRefMedlineWeb of Science

    ↵Rice TW, Wheeler AP, Thompson BT, et al. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA2012;307:795-803. doi:10.1001/jama.2012.137. pmid:22307571.

    CrossRefMedlineWeb of Science

    ↵Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med2011;365:506-17. doi:10.1056/NEJMoa1102662. pmid:21714640.

    CrossRefMedlineWeb of Science

    ↵Finfer S, Chittock DR, Su SY, et al. NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med2009;360:1283-97. doi:10.1056/NEJMoa0810625. pmid:19318384.

    CrossRefMedlineWeb of Science

    ↵Fraser GL, Devlin JW, Worby CP, et al. Benzodiazepine versus nonbenzodiazepine-based sedation for mechanically ventilated, critically ill adults: a systematic review and meta-analysis of randomized trials. Crit Care Med2013;41(Suppl 1):S30-8. doi:10.1097/CCM.0b013e3182a16898. pmid:23989093.

    CrossRefMedline

    ↵Payen D, Mateo J, Cavaillon JM, Fraisse F, Floriot C, Vicaut E. Hemofiltration and Sepsis Group of the Collège National de Réanimation et de Médecine d’Urgence des Hôpitaux extra-Universitaires. Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial. Crit Care Med2009;37:803-10. doi:10.1097/CCM.0b013e3181962316. pmid:19237881.

    CrossRefMedlineWeb of Science

    ↵Borthwick EMJ, Hill CJ, Rabindranath KS, Maxwell AP, McAuley DF, Blackwood B. High-volume haemofiltration for sepsis. Cochrane Database Syst Rev2013;1:CD008075. doi:10.1002/14651858.CD008075.pub2. pmid:23440825.

    Medline

    ↵Schumer W. Steroids in the treatment of clinical septic shock. Ann Surg1976;184:333-41. doi:10.1097/00000658-197609000-00011 pmid:786190.

    CrossRefMedlineWeb of Science

    ↵Patel GP, Balk RA. Systemic steroids in severe sepsis and septic shock. Am J Respir Crit Care Med2012;185:133-9. doi:10.1164/rccm.201011-1897CI. pmid:21680949.

    CrossRefMedlineWeb of Science

    Qiu P, Cui X, Sun J, Welsh J, Natanson C, Eichacker PQ. Antitumor necrosis factor therapy is associated with improved survival in clinical sepsis trials: a meta-analysis. Crit Care Med2013;41:2419-29. doi:10.1097/CCM.0b013e3182982add. pmid:23887234.

    CrossRefMedline

    ↵Panacek EA, Marshall JC, Albertson TE, et al. Monoclonal Anti-TNF: a Randomized Controlled Sepsis Study Investigators. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab’)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med2004;32:2173-82. doi:10.1097/01.CCM.0000145229.59014.6C pmid:15640628.

    CrossRefMedlineWeb of Science

    Fisher CJ Jr, , Dhainaut JF, Opal SM, et al. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. JAMA1994;271:1836-43. doi:10.1001/jama.1994.03510470040032 pmid:8196140.

    CrossRefMedlineWeb of Science

    ↵Opal SM, Fisher CJ Jr, , Dhainaut JF, et al. Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med1997;25:1115-24. doi:10.1097/00003246-199707000-00010 pmid:9233735.

    CrossRefMedlineWeb of Science

    ↵McCloskey RV, Straube RC, Sanders C, Smith SM, Smith CR. CHESS Trial Study Group. Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. Ann Intern Med1994;121:1-5. doi:10.7326/0003-4819-121-1-199407010-00001 pmid:8198341.

    CrossRefMedlineWeb of Science

    ↵Angus DC, Birmingham MC, Balk RA, et al. E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. JAMA2000;283:1723-30. doi:10.1001/jama.283.13.1723 pmid:10755499.

    CrossRefMedlineWeb of Science

    ↵Opal SM, Laterre P-F, Francois B, et al. ACCESS Study Group. Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA2013;309:1154-62. doi:10.1001/jama.2013.2194. pmid:23512062.

    CrossRefMedlineWeb of Science

    ↵Bernard GR, Vincent JL, Laterre PF, et al. Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med2001;344:699-709. doi:10.1056/NEJM200103083441001. pmid:11236773.

    CrossRefMedlineWeb of Science

    ↵Eichacker PQ, Natanson C, Danner RL. Surviving sepsis—practice guidelines, marketing campaigns, and Eli Lilly. N Engl J Med2006;355:1640-2. doi:10.1056/NEJMp068197. pmid:17050887.

    CrossRefMedlineWeb of Science

    ↵Ranieri VM, Thompson BT, Barie PS, et al. PROWESS-SHOCK Study Group. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med2012;366:2055-64. doi:10.1056/NEJMoa1202290. pmid:22616830.

    CrossRefMedlineWeb of Science

    Afshari A, Wetterslev J, Brok J, Møller A. Antithrombin III in critically ill patients: systematic review with meta-analysis and trial sequential analysis. BMJ2007;335:1248-51. doi:10.1136/bmj.39398.682500.25. pmid:18037615.

    Abstract/FREE Full Text

    ↵Warren BL, Eid A, Singer P, et al. KyberSept Trial Study Group. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA2001;286:1869-78. doi:10.1001/jama.286.15.1869 pmid:11597289.

    CrossRefMedlineWeb of Science

    ↵Jaimes F, De La Rosa G, Morales C, et al. Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study). Crit Care Med2009;37:1185-96. doi:10.1097/CCM.0b013e31819c06bc. pmid:19242322.

    CrossRefMedlineWeb of Science

    ↵Root RK, Lodato RF, Patrick W, et al. Pneumonia Sepsis Study Group. Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis. Crit Care Med2003;31:367-73. doi:10.1097/01.CCM.0000048629.32625.5D. pmid:12576938.

    CrossRefMedlineWeb of Science

    ↵Meisel C, Schefold JC, Pschowski R, et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med2009;180:640-8. doi:10.1164/rccm.200903-0363OC. pmid:19590022.

    CrossRefMedlineWeb of Science

    ↵Fink MP, Warren HS. Strategies to improve drug development for sepsis. Nat Rev Drug Discov2014;13:741-58. doi:10.1038/nrd4368. pmid:25190187.

    CrossRefMedline

    ↵Marshall JC. Why have clinical trials in sepsis failed?Trends Mol Med2014;20:195-203. doi:10.1016/j.molmed.2014.01.007. pmid:24581450.

    CrossRefMedlineWeb of Science

    ↵Vincent J-L, Martinez EO, Silva E. Evolving concepts in sepsis definitions. Crit Care Nurs Clin North Am2011;23:29-39. doi:10.1016/j.ccell.2010.12.002. pmid:21316566.

    CrossRefMedline

    ↵Munford RS. Severe sepsis and septic shock: the role of gram-negative bacteremia. Annu Rev Pathol2006;1:467-96. doi:10.1146/annurev.pathol.1.110304.100200. pmid:18039123.

    CrossRefMedlineWeb of Science

    ↵Drazen JM. Transparency for clinical trials--the TEST Act. N Engl J Med2012;367:863-4. doi:10.1056/NEJMe1209433. pmid:22873430.

    CrossRefMedline

    ↵Calvano SE, Xiao W, Richards DR, et al. Inflamm and Host Response to Injury Large Scale Collab. Res. Program. A network-based analysis of systemic inflammation in humans. Nature2005;437:1032-7. doi:10.1038/nature03985. pmid:16136080.

    CrossRefMedlineWeb of Science

    ↵Kamisoglu K, Sleight KE, Calvano SE, Coyle SM, Corbett SA, Androulakis IP. Temporal metabolic profiling of plasma during endotoxemia in humans. Shock2013;40:519-26. doi:10.1097/SHK.0000000000000063. pmid:24089011.

    CrossRefMedline

    ↵Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA. NHLBI ARDS Network. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med2014;2:611-20. doi:10.1016/S2213-2600(14)70097-9. pmid:24853585.

    CrossRefMedline

    ↵Seok J, Warren HS, Cuenca AG, et al. Inflammation and Host Response to Injury, Large Scale Collaborative Research Program. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A2013;110:3507-12. doi:10.1073/pnas.1222878110. pmid:23401516.

    Abstract/FREE Full Text

    ↵Osuchowski MF, Remick DG, Lederer JA, et al. Abandon the mouse research ship? Not just yet!Shock2014;41:463-75. doi:10.1097/SHK.0000000000000153. pmid:24569509.

    CrossRefMedlineWeb of Science

    ↵Efron PA, Mohr AM, Moore FA, Moldawer LL. The future of murine sepsis and trauma research models. J Leukoc Biol2015;98:945-52. doi:10.1189/jlb.5MR0315-127R. pmid:26034205.

    Abstract/FREE Full Text

    ↵Levi M, Van Der Poll T. Thrombomodulin in sepsis. Minerva Anestesiol2013;79:294-8.pmid:23241735.

    MedlineWeb of Science

    ↵Morelli A, Ertmer C, Westphal M, et al. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA2013;310:1683-91. doi:10.1001/jama.2013.278477. pmid:24108526.

    CrossRefMedlineWeb of Science

    ↵Mehta D, Ravindran K, Kuebler WM. Novel regulators of endothelial barrier function. Am J Physiol Lung Cell Mol Physiol2014;307:L924-35. doi:10.1152/ajplung.00318.2014. pmid:25381026.

    Abstract/FREE Full Text

    ↵Serhan CN, Chiang N, Dalli J, Levy BD. Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol2014;7:a016311. doi:10.1101/cshperspect.a016311. pmid:25359497.

    Medline

    ↵Lombardo E, van der Poll T, DelaRosa O, Dalemans W. Mesenchymal stem cells as a therapeutic tool to treat sepsis. World J Stem Cells2015;7:368-79. doi:10.4252/wjsc.v7.i2.368. pmid:25815121.

    CrossRefMedline

    ↵Liu KD, Wilson JG, Zhuo H, et al. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care2014;4:22. doi:10.1186/s13613-014-0022-z. pmid:25593740.

    CrossRefMedline

    ↵Esposito S, Durando P, Bosis S, Ansaldi F, Tagliabue C, Icardi G. ESCMID Vaccine Study Group (EVASG). Vaccine-preventable diseases: from paediatric to adult targets. Eur J Intern Med2014;25:203-12. doi:10.1016/j.ejim.2013.12.004. pmid:24389370.

    CrossRefMedline

    ↵Dellinger RP, Carlet JM, Masur H, et al. Surviving Sepsis Campaign Management Guidelines Committee. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med2004;32:858-73. doi:10.1097/01.CCM.0000117317.18092.E4 pmid:15090974.

    CrossRefMedlineWeb of Science

    ↵Abraham E. New definitions for sepsis and septic shock: continuing evolution but with much still to be done. JAMA2016;315:757-9. doi:10.1001/jama.2016.0290. pmid:26903333.

    CrossRefMedline

 

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