Injuria renal aguda neonatal

1. Selewski DT, Cornell TT, Heung M, et al. Validation of the KDIGO acute kidney injury criteria in a pediatric critical care population. Intensive Care Med.2014; 40(10):1481–1488
2. Sutherland SM, Ji J, Sheikhi FH, et al. AKI in hospitalized children: epidemiology and clinical associations in a national cohort. Clin J Am Soc Nephrol. 2013; 8(10):1661–1669
3. Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL. Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int. 2007; 71(10):1028–1035
4. Alkandari O, Eddington KA, Hyder A, et al. Acute kidney injury is an independent risk factor for pediatric intensive care unit mortality, longer length of stay and prolonged mechanical ventilation in critically ill children: a two-center retrospective cohort study. Crit Care. 2011; 15(3):R146
5. Mammen C, Al Abbas A, Skippen P, et al. Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: a prospective cohort study. Am J Kidney Dis. 2012; 59(4):523–530
6. Askenazi DJ, Feig DI, Graham NM, Hui-Stickle S, Goldstein SL. 3–5 year longitudinal follow-up of pediatric patients after acute renal failure. Kidney Int. 2006; 69(1):184–189
7. Blinder JJ, Goldstein SL, Lee VV, et al. Congenital heart surgery in infants: effects of acute kidney injury on outcomes. J Thorac Cardiovasc Surg. 2012; 143(2):368–374
8. Gadepalli SK, Selewski DT, Drongowski RA, Mychaliska GB. Acute kidney injury in congenital diaphragmatic hernia requiring extracorporeal life support: an insidious problem. J Pediatr Surg. 2011; 46(4):630–635
9. Kaur S, Jain S, Saha A, et al. Evaluation of glomerular and tubular renal function in neonates with birth asphyxia. Ann Trop Paediatr. 2011; 31(2): 129–134
10. Koralkar R, Ambalavanan N, Levitan EB, McGwin G, Goldstein S, Askenazi D. Acute kidney injury reduces survival in very low birth weight infants. Pediatr Res. 2011; 69(4):354–358
11. Sarkar S, Askenazi DJ, Jordan BK, et al. Relationship between acute kidney injury and brain MRI findings in asphyxiated newborns after therapeutic hypothermia. Pediatr Res. 2014; 75(3):431–435
12. Selewski DT, Jordan BK, Askenazi DJ, Dechert RE, Sarkar S. Acute kidney injury in asphyxiated newborns treated with therapeutic hypothermia. J Pediatr. 2013; 162(4):725–729.e1
13. Hinchliffe SA, Sargent PH, Howard CV, Chan YF, van Velzen D. Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle. Lab Invest. 1991; 64(6): 777–784
14. Abrahamson DR. Glomerulogenesis in the developing kidney. Semin Nephrol. 1991; 11(4):375–389
15. Bertram JF, Douglas-Denton RN, Diouf B, Hughson MD, Hoy WE. Human nephron number: implications for health and disease. Pediatr Nephrol. 2011; 26(9): 1529–1533
16. Rodriguez MM, Gomez AH, Abitbol CL, Chandar JJ, Duara S, Zilleruelo GE. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol. 2004; 7(1):17–25
17. Faa G, Gerosa C, Fanni D, et al. Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy. J Matern Fetal Neonatal Med. 2010; 23(suppl 3): 129–133
18. Sutherland MR, Gubhaju L, Moore L, et al. Accelerated maturation and abnormal morphology in the preterm neonatal kidney. J Am Soc Nephrol. 2011; 22(7):1365–1374
19. Carmody JB, Charlton JR. Short-term gestation, long-term risk: prematurity and chronic kidney disease. Pediatrics. 2013; 131(6):1168–1179
20. Rudolph AM, Heymann MA, Teramo KAW, Barrett CT, Raiha NCR. Studies on the circulation of the previable fetus. Pediatr Res. 1971; 5:452–465
21. Jose PA, Fildes RD, Gomez RA, Chevalier RL, Robillard JE. Neonatal renal function and physiology. Curr Opin Pediatr. 1994; 6(2):172–177
22. Paton JB, Fisher DE, DeLannoy CW, Behrman RE. Umbilical blood flow, cardiac output, and organ blood flow in the immature baboon fetus. Am J Obstet Gynecol. 1973; 117(4): 560–566
23. Yao LP, Jose PA. Developmental renal hemodynamics. Pediatr Nephrol. 1995; 9(5):632–637
24. Saint-Faust M, Boubred F, Simeoni U. Renal development and neonatal adaptation. Am J Perinatol. 2014; 31(9): 773–780
25. Wolf G. Angiotensin II and tubular development. Nephrol Dial Transplant. 2002; 17(suppl 9):48–51
26. Yosipiv IV, El-Dahr SS. Developmental biology of angiotensin-converting enzyme. Pediatr Nephrol. 1998; 12(1): 72–79
27. Gleason CA. Prostaglandins and the developing kidney. Semin Perinatol. 1987; 11(1):12–21
28. Brion LP, Fleischman AR, McCarton C, Schwartz GJ. A simple estimate of glomerular filtration rate in low birth weight infants during the first year of life: noninvasive assessment of body composition and growth. J Pediatr. 1986; 109(4): 698–707
29. Vieux R, Hascoet JM, Merdariu D, Fresson J, Guillemin F. Glomerular filtration rate reference values in very preterm infants. Pediatrics. 2010; 125(5). Available at: www.pediatrics.org/cgi/content/full/125/5/e1186
30. Abitbol CL, Seeherunvong W, Galarza MG, et al. Neonatal kidney size and function in preterm infants: what is a true estimate of glomerular filtration rate? J Pediatr. 2014; 164(5):
1026–1031.e2
31. Jetton JG, Askenazi DJ. Acute kidney injury in the neonate. Clin Perinatol. 2014; 41(3):487–502
32. Drukker A, Guignard JP. Renal aspects of the term and preterm infant: a selective update. Curr Opin Pediatr. 2002; 14(2):175–182
33. Miall LS, Henderson MJ, Turner AJ, et al. Plasma creatinine rises dramatically in the first 48 hours of life in preterm infants. Pediatrics. 1999; 104(6). Available at: www.pediatrics.org/cgi/content/full/104/6/e76
34. Guignard JP, Drukker A. Why do newborn infants have a high plasma creatinine? Pediatrics. 1999; 103(4). Available at: www.pediatrics.org/cgi/content/full/103/4/e49
35. Auron A, Mhanna MJ. Serum creatinine in very low birth weight infants during their first days of life. J Perinatol. 2006; 26(12):755–760
36. Sarafidis K, Tsepkentzi E, Diamanti E, et al. Urine neutrophil gelatinase associated lipocalin to predict acute kidney injury in preterm neonates. A pilot study. Pediatr Nephrol. 2014; 29(2): 305–310
37. Tabel Y, Elmas A, Ipek S, Karadag A, Elmas O, Ozyalin F. Urinary neutrophil gelatinase-associated lipocalin as an early biomarker for prediction of acute kidney injury in preterm infants. Am J Perinatol. 2014; 31(2):167–174
38. Genc G, Ozkaya O, Avci B, Aygun C, Kucukoduk S. Kidney injury molecule-1 as a promising biomarker for acute kidney injury in premature babies. Am J Perinatol. 2013; 30(3):245–252
39. Sarafidis K, Tsepkentzi E, Agakidou E, et al. Serum and urine acute kidney injury biomarkers in asphyxiated neonates. Pediatr Nephrol. 2012; 27(9): 1575–1582
40. Askenazi DJ, Koralkar R, Hundley HE, et al. Urine biomarkers predict acute kidney injury in newborns. J Pediatr. 2012; 161(2):270–275.e1
41. Askenazi DJ, Montesanti A, Hunley H, et al. Urine biomarkers predict acute kidney injury and mortality in very low birth weight infants. J Pediatr. 2011; 159 (6):907–912.e1
42. Askenazi DJ, Koralkar R, Levitan EB, et al. Baseline values of candidate urine acute kidney injury biomarkers vary by gestational age in premature infants. Pediatr Res. 2011; 70(3):302–306
43. Schneider J, Khemani R, Grushkin C, Bart R. Serum creatinine as stratified in the RIFLE score for acute kidney injury is associated with mortality and length of stay for children in the pediatric intensive care unit. Crit Care Med. 2010; 38(3):933–939
44. Kidney Disease; Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney
Int Suppl. 2012; 2(1):1–138
45. Askenazi DJ, Griffin R, McGwin G, Carlo W, and Ambalavanan N. Acute kidney injury is independently associated with mortality in very low birth weight infants: a matched case-control analysis. Pediatr Nephrol. 2009; 24(5):991–997
46. Jetton JG, Askenazi DJ. Update on acute kidney injury in the neonate. Curr Opin Pediatr. 2012; 24(2):191–196
47. Cuzzolin L, Fanos V, Pinna B, et al. Postnatal renal function in preterm newborns: a role of diseases, drugs and therapeutic interventions. Pediatr Nephrol. 2006; 21(7):931–938
48. Cataldi L, Leone R, Moretti U, et al. Potential risk factors for the development of acute renal failure in preterm newborn infants: a case control study. Arch Dis Child Fetal Neonatal Ed. 2005; 90(6):F514–F519
49. Aggarwal A, Kumar P, Chowdhary G, Majumdar S, Narang A. Evaluation of renal functions in asphyxiated newborns. J Trop Pediatr. 2005; 51(5): 295–299
50. Gupta BD, Sharma P, Bagla J, Parakh M, Soni JP. Renal failure in asphyxiated neonates. Indian Pediatr. 2005; 42(9): 928–934
51. Stojanovi_c V, Bari_si_c N, Milanovi_c B, Doronjski A. Acute kidney injury in preterm infants admitted to a neonatal intensive care unit. Pediatr Nephrol. 2014; 29(11):2213–2220
52. Momtaz HE, Sabzehei MK, Rasuli B, Torabian S. The main etiologies of acute kidney injury in the newborns hospitalized in the neonatal intensive care unit. J Clin Neonatol. 2014; 3(2): 99–102
53. Vachvanichsanong P, McNeil E, Dissaneevate S, Dissaneewate P, Chanvitan P, Janjindamai W. Neonatal acute kidney injury in a tertiary center in a developing country. Nephrol Dial Transplant. 2012; 27(3):973–977
54. Bolat F, Comert S, Bolat G, et al. Acute kidney injury in a single neonatal intensive care unit in Turkey. World J Pediatr. 2013; 9(4):323–329
55. Mathur NB, Agarwal HS, Maria A. Acute renal failure in neonatal sepsis. Indian J Pediatr. 2006; 73(6):499–502
56. Blatt NB, Srinivasan S, Mottes T, Shanley MM, Shanley TP. Biology of sepsis: its relevance to pediatric nephrology. Pediatr Nephrol. 2014; 29(12):2273–2287
57. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care
Med. 2004; 32(9):1825–1831
58. Vincent JL, De Backer D. Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. Crit Care. 2005; 9 (suppl 4):S9–S12
59. Venkatachalam MA, Weinberg JM. The tubule pathology of septic acute kidney injury: a neglected area of research comes of age. Kidney Int. 2012; 81(4): 338–340
60. Goldstein SL, Kirkendall E, Nguyen H, et al. Electronic health record identification of nephrotoxin exposure and associated acute kidney injury. Pediatrics. 2013; 132(3). Available at:
www.pediatrics.org/cgi/content/full/132/3/e756
61. Menon S, Kirkendall ES, Nguyen H, Goldstein SL. Acute kidney injury associated with high nephrotoxic medication exposure leads to chronic kidney disease after 6 months. J Pediatr. 2014; 165(3):522–527.e2
62. Rhone ET, Carmody JB, Swanson JR, Charlton JR. Nephrotoxic medication exposure in very low birth weight infants. J Matern Fetal Neonatal Med. 2014; 27(14):1485–1490
63. Askenazi DJ, Koralkar R, Hundley HE, Montesanti A, Patil N, Ambalavanan N. Fluid overload and mortality are associated with acute kidney injury in sick near-term/term neonate. Pediatr Nephrol. 2013; 28(4):661–666
64. Alabbas A, Campbell A, Skippen P, Human D, Matsell D, Mammen C. Epidemiology of cardiac surgeryassociated acute kidney injury in neonates: a retrospective study. Pediatr Nephrol. 2013; 28(7):1127–1134
65. Viswanathan S, Manyam B, Azhibekov T, Mhanna MJ. Risk factors associated with acute kidney injury in extremely low birth weight (ELBW) infants. Pediatr Nephrol. 2012; 27(2):303–311
66. Carmody JB, Swanson JR, Rhone ET, Charlton JR. Recognition and reporting of AKI in very low birth weight infants. Clin J Am Soc Nephrol. 2014; 9(12): 2036–2043
67. Mildner RJ, Taub N, Vyas JR, et al. Cytokine imbalance in infants receiving extracorporeal membrane oxygenation for respiratory failure. Biol Neonate. 2005; 88(4):321–327
68. Kurundkar AR, Killingsworth CR, McIlwain RB, et al. Extracorporeal membrane oxygenation causes loss of intestinal epithelial barrier in the newborn piglet. Pediatr Res. 2010; 68(2): 128–133
69. Zwiers AJ, de Wildt SN, Hop WC, et al. Acute kidney injury is a frequent complication in critically ill neonates receiving extracorporeal membrane oxygenation: a 14-year cohort study. Crit Care. 2013; 17(4):R151
70. Eslami Z, Shajari A, Kheirandish M, Heidary A. Theophylline for prevention of kidney dysfunction in neonates with severe asphyxia. Iran J Kidney Dis. 2009; 3(4):222–226
71. Cattarelli D, Spandrio M, Gasparoni A, Bottino R, Offer C, Chirico G. A randomised, double blind, placebo controlled trial of the effect of theophylline in prevention of vasomotor nephropathy in very preterm neonates with respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed. 2006; 91(2):F80–F84
72. Bakr AF. Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia—a study in a developing country. Pediatr Nephrol. 2005; 20(9):1249–1252
73. Jenik AG, Ceriani Cernadas JM, Gorenstein A, et al. A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with
perinatal asphyxia. Pediatrics. 2000; 105(4).
Available at: www.pediatrics.org/cgi/content/full/105/4/E45
74. Al-Wassia H, Alshaikh B, Sauve R. Prophylactic theophylline for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia: a systematic review
and meta-analysis of randomized controlled trials. J Perinatol. 2013; 33(4): 271–277
75. Landoni G, Biondi-Zoccai GG, Tumlin JA, et al. Beneficial impact of fenoldopam in critically ill patients with or at risk for acute renal failure: a meta-analysis of randomized clinical trials. Am J Kidney Dis. 2007; 49(1):56–68
76. Kellum JA, M Decker J. Use of dopamine in acute renal failure: a meta-analysis. Crit Care Med. 2001; 29(8):1526–1531
77. Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J; Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Lancet. 2000; 356(9248):2139–2143
78. Merheb RC, Kruzer KA, Mhanna MJ. The effect of bumetanide in extremely low birth weight infants with acute kidney injury during their first weeks of life. Journal of Clinical Pediatric Nephrology. 2014; 2(1):53–63
79. Oliveros M, Pham JT, John E, Resheidat A, Bhat R. The use of bumetanide for oliguric acute renal failure in preterm infants. Pediatr Crit Care Med. 2011; 12 (2):210–214
80. Goldstein SL, Currier H, Graf CD , Cosio CC, Brewer ED, Sachdeva R. Outcome in children receiving continuous venovenous hemofiltration. Pediatrics. 2001; 107(6):1309–1312
81. Sutherland SM, Zappitelli M, Alexander SR, et al. Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. Am J Kidney Dis. 2010; 55(2):316–325
82. Selewski DT, Cornell TT, Lombel RM, et al. Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy. Intensive Care Med. 2011;37(7):1166–1173
83. Foland JA, Fortenberry JD, Warshaw BL, et al. Fluid overload before continuous hemofiltration and survival in critically ill children: a retrospective analysis. Crit Care Med. 2004; 32(8): 1771–1776
84. Gillespie RS, Seidel K, Symons JM. Effect of fluid overload and dose of replacement fluid on survival in hemofiltration. Pediatr Nephrol. 2004; 19(12):1394–1399
85. Hayes LW, Oster RA, Tofil NM, Tolwani AJ. Outcomes of critically ill children requiring continuous renal replacement therapy. J Crit Care. 2009; 24(3):394–400
86. Arikan AA, Zappitelli M, Goldstein SL, Naipaul A, Jefferson LS, Loftis LL. Fluid overload is associated with impaired oxygenation and morbidity in critically ill children. Pediatr Crit Care Med. 2012; 13(3):253–258
87. Bouchard J, Soroko SB, Chertow GM, et al; Program to Improve Care in Acute Renal Disease (PICARD) Study Group. Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. Kidney Int. 2009; 76(4):422–427
88. Macedo E, Bouchard J, Soroko SH, et al; Program to Improve Care in Acute Renal Disease Study. Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients. Crit Care. 2010; 14(3):R82
89. Brierley J, Carcillo JA, Choong K, et al. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine [published correction appears in Crit Care Med. 2009;37(4):1536]. Crit Care Med. 2009; 37(2): 666–688
90. Kaddourah A, Goldstein SL. Renal replacement therapy in neonates. Clin Perinatol. 2014; 41(3):517–527
91. Harshman LA, Muff-Luett M, Neuberger ML, et al. Peritoneal dialysis in an extremely low-birth weight infant with acute kidney injury. Clin Kidney J. 2014; 7(6):582–585
92. Alparslan C, Yavascan O, Bal A, et al. The performance of acute peritoneal dialysis treatment in neonatal period. Ren Fail. 2012; 34(8):1015–1020
93. Unal S, Bilgin L, Gunduz M, Uncu N, Azili MN, Tiryaki T. The implementation of neonatal peritoneal dialysis in a clinical setting. J Matern Fetal Neonatal Med. 2012; 25(10):2111–2114
94. Oyachi N, Obana K, Kimura S, Kubo M, Naito A, Nemoto A. Use of a flexible Blake(R) silicone drains for peritoneal dialysis in the neonatal intensive care unit. Pediatr Int. 2011; 53(3):417–418
95. Yu JE, Park MS, Pai KS. Acute peritoneal dialysis in very low birth weight neonates using a vascular catheter. Pediatr Nephrol. 2010; 25(2):367–371
96. Bridges BC, Askenazi DJ, Smith J, Goldstein SL. Pediatric renal replacement therapy in the intensive care unit. Blood Purif. 2012; 34(2): 138–148
97. Askenazi DJ, Goldstein SL, Koralkar R, et al. Continuous renal replacement therapy for children ,/=10 kg: a report from the prospective pediatric continuous renal replacement therapy
registry. J Pediatr. 2013; 162(3):587–592.e3
98. Ronco C, Garzotto F, Ricci Z. CA.R.PE.DI.E.M. (Cardio-Renal Pediatric Dialysis Emergency Machine): evolution of continuous renal replacement therapies in infants. A personal journey.
Pediatr Nephrol. 2012; 27(8):1203–1211
99. Ronco C, Garzotto F, Brendolan A, et al. Continuous renal replacement therapy in neonates and small infants: development and first-in-human use of a miniaturised machine (CARPEDIEM). Lancet. 2014; 383(9931): 1807–1813
100. Hothi DK. Designing technology to meet the therapeutic demands of acute renal injury in neonates and small infants. Pediatr Nephrol. 2014; 29(10): 1869–1871
101. Basile DP. The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function. Kidney Int. 2007; 72(2):151–156
102. Coca SG, Singanamala S, Parikh CR. Chronic kidney disease after acute kidney injury: a systematic review and metaanalysis. Kidney Int. 2012; 81(5):442–448
103. Bruel A, Rozé JC, Flamant C, Simeoni U, Roussey-Kesler G, Allain-Launay E. Critical serum creatinine values in very preterm newborns. PLoS ONE. 2013; 8(12):e84892