Pequeño beneficio en la supervivencia con graves secuelas | 17 FEB 19

Adrenalina después del paro cardíaco duplica el riesgo de daño cerebral

Una probabilidad modestamente mayor de estar vivo debe equilibrarse con una probabilidad mucho mayor de que sea una vida empañada por una discapacidad grave
Autor/a: Callaway Clifton W., Donnino Michael W..  Fuente: N Engl J Med DOI: 10.1056/NEJMe1808255.  Testing Epinephrine for Out-of-Hospital Cardiac Arrest.
INDICE:  1. Página 1 | 2. Referencias bibliográficas
Referencias bibliográficas
  1. Benjamin EJ, Virani SS, Callaway CW, et al. Heart Disease and Stroke Statistics — 2018 update: a report from the American Heart Association. Circulation 2018;137(12):e67-e492.
  2. Gräsner JT, Lefering R, Koster RW, et al. Corrigendum to “EuReCa ONE — 27 Nations, ONE Europe, ONE Registry A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe” [Resuscitation 105 (2016) 188-195]. Resuscitation 2016;109:145-146.
  3. Perkins GD, Travers AH, Berg RA, et al. Adult basic life support and automated external defibrillation: 2015 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation 2015;95:e43-e69.
  4. Soar J, Callaway CW, Aibiki M, et al. Advanced life support: 2015 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation 2015;95:e71-e120.
  5. Perkins GD, Cottrell P, Gates S. Is adrenaline safe and effective as a treatment for out of hospital cardiac arrest? BMJ 2014;348:g2435-g2435.
  6. Callaway CW. Epinephrine for cardiac arrest. Curr Opin Cardiol 2013;28:36-42.
  7. Larsson PT, Wallén NH, Egberg N, Hjemdahl P. Alpha-adrenoceptor blockade by phentolamine inhibits adrenaline-induced platelet activation in vivo without affecting resting measurements. Clin Sci (Lond) 1992;82:369-376.
  8. Ristagno G, Tang W, Huang L, et al. Epinephrine reduces cerebral perfusion during cardiopulmonary resuscitation. Crit Care Med 2009;37:1408-1415.
  9. Lin S, Callaway CW, Shah PS, et al. Adrenaline for out-of-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials. Resuscitation 2014;85:732-740.
  10. Loomba RS, Nijhawan K, Aggarwal S, Arora RR. Increased return of spontaneous circulation at the expense of neurologic outcomes: is prehospital epinephrine for out-of-hospital cardiac arrest really worth it? J Crit Care 2015;30:1376-1381.
  11. Kleinman ME, Perkins GD, Bhanji F, et al. ILCOR scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care: a consensus statement. Resuscitation 2018;127:132-146.
  12. Perkins GD, Quinn T, Deakin CD, et al. Pre-hospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug administration In Cardiac arrest (PARAMEDIC-2): trial protocol. Resuscitation 2016;108:75-81.
  13. Monsieurs KG, Nolan JP, Bossaert LL, et al. European Resuscitation Council guidelines for resuscitation 2015. 1. Executive summary. Resuscitation 2015;95:1-80.
  14. Perkins GD, Jacobs IG, Nadkarni VM, et al. Cardiac arrest and cardiopulmonary resuscitation outcome reports: update of the Utstein Resuscitation Registry templates for out-of-hospital cardiac arrest. Resuscitation 2014;96:328-340.
  15. Nolan JP, Soar J, Cariou A, et al. European Resuscitation Council and European Society of Intensive Care Medicine guidelines for post-resuscitation care 2015: section 5 of the European Resuscitation Council guidelines for resuscitation 2015. Resuscitation 2015;95:202-222.
  16. Haywood K, Whitehead L, Nadkarni VM, et al. COSCA (Core Outcome Set for Cardiac Arrest) in adults: an advisory statement from the International Liaison Committee on Resuscitation. Resuscitation
  17. Guidelines 2000 for cardiopulmonary resuscita
 

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