Mecanismos moleculares de acción de los corticoides - IntraMed - Artículos
IntraMed
 
INGRESAR
¿Olvidó su contraseña?
Regístrese ahora
Contáctenos
Centro de ayuda
  Inicio
 Artículos
 Puntos de vista
 Entrevistas
 Noticias médicas
 Campus Virtual
 Journal
 Biblioteca Virtual
 Investigaciones
 Foros
 Eventos
 Vademécum
 Arte & Cultura
 Tecnología
 » Enlaces
 » Encuestas
 » Clasificados
 » Pág. Profesionales
 » Tarjetas Virtuales
Artículos
          
  
26 MAR 03 | Revisión
Mecanismos moleculares de acción de los corticoides
Sus principales funciones son mantener la glucemia y evitar la hipotensión arterial, modular la respuesta inmune e inflamatoria y los mecanismos de adaptación al stress.

Dr. Edgardo Jares(1), Dr. Omar Pignataro (2)
Archivos de Alergia e inmunología clínica
AAIC, VOLUMEN 33 Número 1 Enero-Marzo Año 2002
 
ÍNDICE 
Desarrollo
Ingreso a células
Acción nuclear
Factores transcripcionales más importantes en asma
Apoptosis y proliferación celular
Corticoides y â agonistas
Importancia del patrón de acetilación de histonas
Bibliografia
Bibliografia

1. Kemp JP Guidelines update: where do the new therapies fit in the management of asthma? NHLBI and WHO Global Initiative for Asthma Drugs 2000; 59 Suppl 1: 23-28.
2. Newton R. Molecular mechanisms of glucocorticoid action: what is important? Thorax 2000; 55: 603-613.
3. Barnes, P. J. (2001). Corticosteroids, IgE, and atopy. J. Clin. Investig. 107: 265-266.
4. Jabara, H.H., Ahern, D.J., Vercelli, D., and Geha, R.S. 1991. Hydrocortisone and IL-4 induce IgE isotype switching in human â cells. J. Immunol. 147: 1557-1560.
5. Zieg, G., Lack, G., Harbeck, R.J., Gelfand, E.W., and Leung, D.Y. 1994. In vivo effects of glucocorticoids on IgE production. J. Allergy Clin. Immunol. 94: 222-230.
6. Jabara, H.H., Brodeur, S.R., and Geha, R.S. 2001. Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching. J. Clin. Invest. 107: 371-378.
7. Iwasaki Y, Aoki Y, Katahira M, Oiso Y, Saito H 1997 Nongenomic mechanisms of glucocorticoid inhibition of adrenocorticotropin secretion: possible involvement of GTP-binding protein. Biochem Biophys Res Commun 235: 295-299.
8. Munck A, Mendel D, Smith L y col. Glucocorticoid receptors and actions. Am Rev Respir Dis, 1990; 141: S2-S10.
9. Bamberger GM, Bamberger AM, de Castro M y col. Glucocortcoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 1995; 95: 2435-41.
10. Oakley RH, Jewell CM, Judt MR y col. The dominant negative activity of the human glucocorticoid receptor beta isoform. 163, 5, april 2001, 1219-1225.
14. Kraft M, Vianna EO, Martin RJM, Leung DYM. Nocturnal asthma is associated with reduced glucocorticoid receptor binding affinity and decreased steroid responsiveness at night. J Allergy Clin Immunol 1999; 103: 66-71.
15. Tak H. LeBarnes P. Molecular mechanisms of steroid action in asthma. J Allergy Clin Immunol 1996; 97: 159-68
16. Dahlman-Wright K, Wright A, Gustafsson JA, Carlstedt- Duke J. Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acids. J Biol Chem. 1991 Feb 15; 266(5): 3107-12.
17. Reichardt, H.M. et al. DNA binding of the glucocorticoid receptor is not essential for survival. Cell. 1998. 93: 531-541.
18. Barnes P. Regulation of inflamatory gene expression in asthma. Comunicación Personal. Meeting American Academy of Allergy, Asthma, and Immunology, New Orleans, March 2001.
19. Yao XL, Cowan MJ, Gladwin MT y col. Dexamethasone alters arachidonate relase from human epithelial cells by induction of p11 protein synthesis and inhibition of phospholipase A2 activity. J Biol Chem. 1999; 274: 17202-8.
20. Mak JC, Nishikawa M, Barnes PJ. Glucocorticosteroids increased beta 2 adrenergic receptor transcription in human lung. Am J Physiol 1995; 268: 1041-6.
21. Barnes P. Mechanism of action of glucocorticoids in asthma. Am J Respir Crit Care Med 1996; 154: S21-S27.
22. Bamberger C, Schulte H, Chrousos G. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocrine Reviews 1996, 17,3: 245-261.
23. Jenkins B, Pullen C, Darimont D. Novel glucocorticoid receptor coactivator effector mechanisms. Trends Endocr Metab 2001, 12; 3: 122-126.
24. Poon M, Liu B, Taubman M. Identification of a novel dexamethasone- sensitive RNA-destabilizing region on rat monocyte chemoattractant protein 1 mRNA. Mol Cell Biol. 1999 Oct; 19(10): 6471-8.
25. Kern J, Warnock L, McCafferty J. The 3' untranslated region of IL-1b regulates protein production. J Immunol 1997; 158: 1187-93
26. Anderson G. Interation between corticosteroids and b-adrenergic agonists in asthma disease induction, progression, and exacerbation. Am J Respir Crit Care Med 2000; 161: S188-S196.
27. Huang S, Hershey J. Translational initiation factor expression and ribosomal protein gene expression are repressed coordinately but by different mechanisms in murine lymphosarcoma cells treated with glucocorticoids. Mol Cell Biol. 1989 Sep; 9(9): 3679-84.
28. Barnes P, Adcock I. Transcription factors and asthma. Eur Respir J 1998; 12: 221-234.
29. Chen F, Castranova V, Shi X, Demers L. New Insights into the Role of Nuclear Factor-kB, a Ubiquitous Transcription Factor in the Initiation of Diseases Clinical Chemistry. 1999; 45: 7-17.
30. Zhong, H., H. SuYang, H. Erdjument-Bromage, P. Tempst, and S. Gosh. 1997. The transcriptional activity of NFkB is regulated by the IkB-associated PKAc subunit through a
cyclic AMP-independent mechanism. Cell 89: 413-424.
31. Zhong, H., R. E. Voll, and S. Ghosh. 1998. Phosphorylation of NF-kB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the co-activator CBP/p300. Mol. Cell 1: 661-671.
32. Na, S.-Y., S.-K. Lee, S.-J. Han, H.-S. Choi, S.-Y. Im, and J. W. Lee. 1998. Steroid receptor co-activator-1 interacts with the p50 subunit and coactivates nuclear factor kB-mediated transactivation. J. Biol. Chem. 273: 10831-1083.
33. Heery, D. M., E. Kalkhoven, S. Hoare, and M. G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to the nuclear receptors. Nature 387: 733-736.
34. McInerney, E. M., D. W. Rose, S. E. Flynn, S. Westin, T. M. Mullen, A. Krones, J. Inostroza, J. Torchia, R. T. Nolte, N. Assa- Munt, M. V. Milburn, C. K. Glass, and M. G. Rosenfeld. 1998. Determinants of co-activator LXXLL motif specificity in nuclear
receptor transcriptional activation. Genes Dev. 12: 3357-3368.
35. Torchia, J., D. W. Rose, J. Inostroza y. Kamei, S. Westin, C. K. Glass, and M. G. Rosenfeld. 1997. The transcriptional coactivator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387: 677-684.
36. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhacer sequences. Cell 1986; 46: 705-716.
37. Auphan N, Di Donato J, Rosette C y col. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science. 1995 Oct 13; 270(5234): 286-90.
38. Newton R, Hart LA, Stevens DA. Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factor-kappaB (NF-kappaB) and kappaB-dependent transcription in epithelial cells. Eur J Biochem. 1998 May 15; 254(1): 81-9.
39. Scheinman RI, Gualberto A, Jewell CM y col Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol Cell Biol. 1995 Feb; 15(2): 943-53.
40. Mukaida N, Morita M, Ishikawa Y y col. Novel mechanism of glucocorticoid mediated gene repression. Nuclear factor kappa B is target for glucocorticoid mediated interleukin 8
gene repression. J Biol Chem 1994; 269: 13289-95.
41. Van der Saag P, Caldenhoven E, van de Stolpe A. Molecular mechanisms of steroid action: a novel type of cross-talk between glucocorticoids and NF-kB transcription factors. Eur Respir J 1996; 9,suppl.22: S146-S153.
42. Vanden Berghe W, Francesconi E, De Bosscher K, Resche- Rigon M, Haegeman G. Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappaB-dependent mechanism. Mol Pharmacol. 1999 Oct; 56(4): 797-806.
43. Ray KP, Farrow S, Daly M, Talabot F, Searle N. Induction of the E-selectin promoter by interleukin 1 and tumour necrosis factor alpha, and inhibition by glucocorticoids. Biochem J. 1997 Dec 1; 328 ( Pt 2): 707-15.

Specificity and mechanisms of action. J Biol Chem, 1999; 274: 27857-66. 11. Leung D, Chrousos G. Is There a role for glucocorticoid receptor beta in glucocorticoid-dependent asthmatics?. Am J Respir Crit Care Med 2000; 162: 1-3 . 12. Sousa A, Lane S, Cidlowski J, Staynov D, Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor â isoform. J Allergy Clin Immun 2000; 105, 5:
13. Kraft M, Hamid Q, Chrousos G, Martin R, Leung D Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible? Am. J. Respir. Crit. Care Med., 44. Hart L, Lim S, Adckock I, Barnes P, Chung K. Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor-kB in asthma. Am J Respir Crit Care Med 2000; 161: 224-231.
45. Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell. 1990 Sep
21; 62(6): 1205-15.
46. Tao Y, Williams-Skipp J. Biol. Chem., Vol. 276, Issue 4, 2329-2332, January 26, 2001C, Scheinman R. Mapping of Glucocorticoid Receptor DNA Binding Domain Surfaces Contributing to Transrepression of NF-kB and Induction of Apoptosis J.
Biol. Chem., 276, 4, 2329-2332, 26, 2001.
47. Konig H, Ponta H, Rahmsdorf HJ, Herrlich P. Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO J. 1992 Jun; 11(6): 2241-6.
48. Didonato J, Saatcioglu F, Karin M. Molecular mechanisms of immunosuppression and antiinflamatory activities by glucocorticoids. Am J Respir Crit Care Med 1996; 154: S11-15.
49. Stocklin E, Wissler M, Guoillex F y col. Funtional interactions between Stats and the glucocorticoid receptor. Nature 1996; 383: 726-728.
50. Ghaffar O, Christodoulopoulos P, Lamkhioued B, Wright E, Ihaku D, Nakamura Y, et al. In vivo expression of signal transducer and activator of transcription factor 6 (STAT6) in nasal mucosa from atopic allergic rhinitis: effect of topical corticosteroids. Clin Exp Allergy 2000; 30: 86-93.
51. Yang, X. J., V. V. Ogryzkao, J. Nishikawa, B. H. Howard, and Y. Nakatani. 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382: 319-324.
52. Spencer, T. E., G. Jenster, M. M. Burcin, C. D. Assis, J. Zhou, C. A. Mizzen, N. J. McKenna, S. A. Onate, S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. 1997. Steroid receptor co-activator- 1 is a histone acetyltransferase. Nature 289: 194-198.
53. Korzus, E., J. Torchia, D. W. Rose, L. Xu, R. Kurokawa, E. M. McInerney, T. M. Mullen, C. K. Glass, and M. G. Rosenfeld. 1998. Transcription factor-specific recruitment of co-activators and their acetyltransferase functions. Science 279: 703-707.
54. Sheppard K, Rose D, Haque Z, Kurokawa R, McInerney E, Westin S, Thanos D, Michael G. Rosenfeld M, Christopher K., Glass C, Collins T Transcriptional Activation by NF-kB Requires Multiple Coactivators Molecular and Cellular Biology, 1999 19, 9: 6367-6378.
55. Schiltz L, Mizzen C, Vassilev A, Cook R, Allis D, Nakatani YOverlapping but Distinct Patterns of Histone Acetylation by the Human Coactivators p300 and PCAF within Nucleosomal Substrates. J Biol Chem, 274, 3: 1189-1192, 1999.
56. Ito K, Barnes P, Adcock I. Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1b-Induced Histone H4 Acetylation on Lysines 8 and 12 Molecular and Cellular Biology, September 2000; 20,18: 6891-6903.
57. Wu, R. S., H. T. Panusz, C. L. Hatch, and W. M. Bonner. 1986. Histones and their modifications. CRC Crit. Rev. Biochem. 20: 201-263.
58. De Bosscher K, Vanden Berghe W, Vermeulen L, Plaisance S, Boone E, Haegeman G. Glucocorticoids repress NF-kBdriven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell Proc. Natl. Acad. Sci. USA, 97, 8: 3919-3924, 2000.
59. Drouin J, Maira M, Philips A. Novel mechanism of action for Nur77 and antagonism by glucocorticoids: a convergent mechanism for CRH activation and glucocorticoid repression of POMC gene transcription. J Steroid Biochem Mol Biol 1998; 65: 59-63.
60. Philips A, Maira M, Mullick A, Chamberland M, Lesage S, Hugo P, et al. Antagonism between Nur77 and glucocorticoid receptor for control of transcription. Mol Cell Biol 1997; 17: 5952-9.
61. Nieto MA, Gonzalez A, Gambon F, Diaz-Espada F, Lopez- Rivas A.Apoptosis in human thymocytes after treatment with glucocorticoids. Clin Exp Immunol. 1992 May; 88(2): 341-4.
62. Jamieson C, Yamamoto K. Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling Proc. Natl. Acad. Sci. USA, 97,13: 7319-7324, 2000.
63. Shiyou Chen, Nicholas J., and S. Stoney Simons Jr. Evidence for a Common Step in Three Different Processes for Modulating the Kinetic Properties of Glucocorticoid Receptor-induced Gene Transcription J. Biol. Chem., Vol. 275, Issue 39, 30106-30117, September 29, 2000.
64. Jackson, D. A., Collier, C. D., Oshima, H., and Simons, S. S., Jr. Modulation of TAT gene induction by glucocorticoids involves a neutralizing sequence (1998) J. Steroid Biochem. Mol. Biol. 66, 79-91.
65. Szapary, D., Xu, M., and Simons, S. S., Jr. Induction Properties of a Transiently Transfected Glucocorticoid-responsive Gene Vary with Glucocorticoid Receptor Concentration (1996) J. Biol. Chem. 271, 30576-30582.
66. Szapary, D., Huang, Y., and Simons, S. S., Jr. Opposing effects of corepressor and coactivators in determining the doseresponse curve of agonists, and residual agonist activity of antagonists, for glucocorticoid receptor-regulated gene expression. (1999) Mol. Endocrinol. 13, 2108-2121.
67. Krstic, M. D., Rogatsky, I., Yamamoto, K. R. & Garabedian, M. J. Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor(1997) Mol. Cell. Biol. 17, 3947-3954.
68. Rogatsky, I., Logan, S. K. & Garabedian, M. J. Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase.(1998) Proc. Natl. Acad. Sci. USA 95, 2050-2055
69. Vayssiere BM, Dupont S, Choquart A y col. Syntethic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo. Mol Endo- crinol 1997; 11: 1254-55
70. Meyer T, Carlstedt-Duke J, Meyer T y Starr D. Aweak TATA box is a prerequisite for glucocorticoid dependent repression of the osteocalcin gene. J Biolog Chem, 1997, 272: 30709-30714.
71. Belvisi M, Wicks S, Battram C, Bottoms S, Redford J y col Therapeutic Benefit of a Dissociated Glucocorticoid and the Relevance of In Vitro Separation of Transrepression from Transactivation Activity. Journal Immunology, 2001, 166: 1975-1982.
72. Eickelberg O, Roth M, Lörx R, Bruce V, Rüdiger J, Johnson M y Lutz-Henning Block Ligand-independent Activation of the Glucocorticoid Receptor by b2-Adrenergic Receptor Agonists in Primary Human Lung Fibroblasts and Vascular Smooth Muscle Cells. J Biol Chem, Vol. 274, Issue 2, 1005-1010, January 8, 1999.
73. Schmidt P, Holsboer F y Spengler D. ß2-Adrenergic Receptors Potentiate glucocorticoid Receptor Transactivation via G Protein ß-Subunits and the Phosphoinositide 3-Kinase Pathway Molecular Endocrinology 15 (4): 553-564. 2001.
74. Hancox R, Stevens D, Adcock I, Barnes P, Taylor R. Effects of inhaled b agonist and corticosteroid treatment on nuclear transcription factors in bronchial mucosa in asthma Thorax 1999; 54: 488-492 (June).


 
« Página anterior
          
  


 Comentarios de los lectores
 

Usted debe estar registrado para expresar su opinión.
Si ya es usuario de IntraMed o desea registrase como nuevo
usuario, ingrese aquí

 



Eventos

» XIV Congreso SADI 2014 - Rosario, Argentina
» VIII Congreso Argentino de Zoonosis - La Plata, Argentina
» Abordaje Integral del Adolescente - A distancia
» V Congreso Interamericano de Medicina de Emergencias - Buenos Aires, Argentina
» 15° Congreso Internacional de Medicina Interna del Hospital - Buenos Aires, Argentina
» Máster en Gestión de Centros y Servicios de Salud - A distancia
» Máster en Medicina Antienvejecimiento y Longevidad - A distancia
» VII Simposio Internacional de HTA-Rosario - Rosario, Argentina
» X Simposio Internacional de CIDEMO 2014 - Mar del Plata, Argentina
» Residencia de Emergencias - Pilar, Argentina

Foros

» Narativa y Medicina
» Kinesiología y Fisioterapia
» Prevención Cardiovascular
» Medicina Legal
» Médicos Residentes
» Enfermería
» Bioética
» Neurología
» Jerga Médica
» Estudiantes
» Salud Mental
» Tocoginecología
» Clínica Médica
» Cirugía
» Pediatría
» Cardiología
» Búsqueda Bibliográfica

Más comentados
1. 40 cosas que los médicos no deberíamos olvidar
2. Curso Virtual de Electrocardiografía Clínica IntraMed
3. Necesidad del razonamiento clínico en la era de la medicina basada en la evidencia
4. Semana Mundial de la Inmunización
5. Diagnóstico diferencial del ojo rojo
Más visitados
1. Puesta al día: Lumbalgia
2. Tratamiento del shock séptico
3. Necesidad del razonamiento clínico en la era de la medicina basada en la evidencia
4. 40 cosas que los médicos no deberíamos olvidar
5. Puesta al día: Mal de Chagas


Quiénes somos | Contáctenos | Términos y condiciones de uso | Todos los derechos reservados | Copyright 1997-2014